Gamma Knife treatment of recurrent CNS metastases of pancreatic origin: a case report and review of the literature

Subha Perni; Tony J Wang; Jerry Lesser; Christopher Mandigo; Steven R Isaacson; David P Horowitz

doi:10.2217/cns-2016-0026

Gamma Knife treatment of recurrent CNS metastases of pancreatic origin: a case report and review of the literature

CNS Oncol. 2017 Apr;6(2):111-118. doi: 10.2217/cns-2016-0026.

Authors

Subha Perni¹, Tony J Wang^{1

2}, Jerry Lesser¹, Christopher Mandigo³, Steven R Isaacson¹, David P Horowitz^{1

2}

Affiliations

¹ Department of Radiation Oncology, Columbia University/New York Presbyterian Hospital, New York, NY, USA.
² Herbert Irving Comprehensive Cancer Center, Columbia University/New York Presbyterian Hospital, New York, NY, USA.
³ Department of Neurosurgery, Columbia University/New York Presbyterian Hospital, New York, NY, USA.

Abstract

Brain metastases (BM) of pancreatic origin are extremely rare. We review the literature around BM of pancreatic origin and describe a 38-year-old woman who developed BM 10 months after pancreaticoduodenectomy for treatment of pancreatic adenocarcinoma. She underwent resection and fractionated stereotactic radiotherapy followed by re-resection and Gamma Knife radiosurgery (GKRS) when the lesion recurred. She then developed two new BM, and was treated with GKRS. The patient is alive without progression 38 months after her most recent GKRS.

Keywords: brain tumor; metastasis; radiotherapy.

Publication types

Case Reports
Review

MeSH terms

Adult
Central Nervous System Neoplasms / diagnostic imaging
Central Nervous System Neoplasms / secondary*
Central Nervous System Neoplasms / surgery*
Female
Humans
Magnetic Resonance Imaging
Pancreatic Neoplasms / pathology*
Radiosurgery / methods*