Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates.
Böttcher A, Büttner M, Tritschler S, Sterr M, Aliluev A, Oppenländer L, Burtscher I, Sass S, Irmler M, Beckers J, Ziegenhain C, Enard W, Schamberger AC, Verhamme FM, Eickelberg O, Theis FJ, Lickert H.
Böttcher A, et al.
Nat Cell Biol. 2021 Jan;23(1):23-31. doi: 10.1038/s41556-020-00617-2. Epub 2021 Jan 4.
Nat Cell Biol. 2021.
PMID: 33398177
Finally, Wnt/PCP-activated Lgr5(+) ISCs are molecularly indistinguishable from Wnt/beta-catenin-activated Lgr5(+) ISCs, suggesting that lineage priming and cell-cycle exit is triggered at the post-transcriptional level by polarity cues and a switch from canonical to non-canonical …
Finally, Wnt/PCP-activated Lgr5(+) ISCs are molecularly indistinguishable from Wnt/beta-catenin-activated Lgr5(+) ISCs, suggesting that line …