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Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages.
Rowton M, Perez-Cervantes C, Hur S, Jacobs-Li J, Lu E, Deng N, Guzzetta A, Hoffmann AD, Stocker M, Steimle JD, Lazarevic S, Oubaha S, Yang XH, Kim C, Yu S, Eckart H, Koska M, Hanson E, Chan SSK, Garry DJ, Kyba M, Basu A, Ikegami K, Pott S, Moskowitz IP. Rowton M, et al. Among authors: eckart h. Dev Cell. 2022 Sep 26;57(18):2181-2203.e9. doi: 10.1016/j.devcel.2022.08.009. Epub 2022 Sep 14. Dev Cell. 2022. PMID: 36108627 Free PMC article.
Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.
Guzzetta A, Koska M, Rowton M, Sullivan KR, Jacobs-Li J, Kweon J, Hidalgo H, Eckart H, Hoffmann AD, Back R, Lozano S, Moon AM, Basu A, Bressan M, Pott S, Moskowitz IP. Guzzetta A, et al. Among authors: eckart h. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15712-15723. doi: 10.1073/pnas.1914167117. Epub 2020 Jun 19. Proc Natl Acad Sci U S A. 2020. PMID: 32561646 Free PMC article.
The DGCR5 long noncoding RNA may regulate expression of several schizophrenia-related genes.
Meng Q, Wang K, Brunetti T, Xia Y, Jiao C, Dai R, Fitzgerald D, Thomas A, Jay L, Eckart H, Grennan K, Imamura-Kawasawa Y, Li M, Sestan N, White KP, Chen C, Liu C. Meng Q, et al. Among authors: eckart h. Sci Transl Med. 2018 Dec 19;10(472):eaat6912. doi: 10.1126/scitranslmed.aat6912. Epub 2018 Dec 13. Sci Transl Med. 2018. PMID: 30545965 Free PMC article.