Investigations into the use of a polyfluorooctanol as an auxiliary component for an aldol reaction

Jason Eames; Hasina Khanom

doi:10.3390/90500266

Investigations into the use of a polyfluorooctanol as an auxiliary component for an aldol reaction

Molecules. 2004 Apr 30;9(5):266-77. doi: 10.3390/90500266.

Authors

Jason Eames¹, Hasina Khanom

Affiliation

¹ Department of Chemistry, Queen Mary, University of London, London E1 4NS, UK. J.Eames@qmul.ac.uk

Abstract

Results are reported on the efficiency of polyfluorooctanol as a perfluorous auxiliary component in the aldol reaction between the enolate derived from polyfluorooctyl acetate and 2-fluorobenzaldehyde. Reduction of the corresponding polyfluoro beta-hydroxy ester with Super Hydride gave the required 1,3-diol in good yield.

MeSH terms

Aldehydes / chemistry*
Catalysis
Hydrocarbons, Fluorinated / chemistry*
Models, Chemical
Molecular Structure
Stereoisomerism

Substances

Aldehydes
Hydrocarbons, Fluorinated