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A new triazolyl-indolo-quinoxaline induces apoptosis in gastric cancer cells by abrogating the STAT3/5 pathway through upregulation of PTPεC.
Suresh RN, Jung YY, Mohan CD, Gowda SV, Harsha KB, Mantelingu K, Sethi G, Ahn KS, Rangappa KS. Suresh RN, et al. Among authors: harsha kb. Drug Dev Res. 2023 Dec;84(8):1724-1738. doi: 10.1002/ddr.22117. Epub 2023 Sep 27. Drug Dev Res. 2023. PMID: 37756467
Among the newly synthesized compounds, 2,3-difluoro-6-((1-(3-fluorophenyl)-1H-1,2,3-triazol-5-yl)methyl)-6H-indolo[2,3-b]quinoxaline (DTI) displayed selective cytotoxicity against GC cells over their normal counterpart. Flow cytometric analysis, annexin-V-fluorescein isoth …
Among the newly synthesized compounds, 2,3-difluoro-6-((1-(3-fluorophenyl)-1H-1,2,3-triazol-5-yl)methyl)-6H-indolo[2,3-b]quinoxaline (DTI) d …