Overexpression of sortilin is associated with 5-FU resistance and poor prognosis in colorectal cancer.
Blondy S, Talbot H, Saada S, Christou N, Battu S, Pannequin J, Jauberteau MO, Lalloué F, Verdier M, Mathonnet M, Perraud A.
Blondy S, et al.
J Cell Mol Med. 2021 Jan;25(1):47-60. doi: 10.1111/jcmm.15752. Epub 2020 Dec 16.
J Cell Mol Med. 2021.
PMID: 33325631
Free PMC article.
Acquired resistance to 5-FU contributes to both poor patient prognosis and relapse, emphasizing the need to identify biomarkers. Sortilin, a vacuolar protein sorting 10 protein (Vps10p), implicated in protein trafficking, is over expressed in CRC cell lines cultured 72 hou …
Acquired resistance to 5-FU contributes to both poor patient prognosis and relapse, emphasizing the need to identify biomarkers. Sort …