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Page 1
USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism.
Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2315163120. doi: 10.1073/pnas.2315163120. Epub 2023 Dec 6.
Proc Natl Acad Sci U S A. 2023.
PMID: 38055744
USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.
Ruiz EJ, Pinto-Fernandez A, Turnbull AP, Lan L, Charlton TM, Scott HC, Damianou A, Vere G, Riising EM, Da Costa C, Krajewski WW, Guerin D, Kearns JD, Ioannidis S, Katz M, McKinnon C, O'Connell J, Moncaut N, Rosewell I, Nye E, Jones N, Heride C, Gersch M, Wu M, Dinsmore CJ, Hammonds TR, Kim S, Komander D, Urbe S, Clague MJ, Kessler BM, Behrens A.
Ruiz EJ, et al. Among authors: scott hc.
Elife. 2021 Oct 12;10:e71596. doi: 10.7554/eLife.71596.
Elife. 2021.
PMID: 34636321
Free PMC article.
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Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity.
Pinto-Fernandez A, Salio M, Partridge T, Chen J, Vere G, Greenwood H, Olie CS, Damianou A, Scott HC, Pegg HJ, Chiarenza A, Díaz-Saez L, Smith P, Gonzalez-Lopez C, Patel B, Anderton E, Jones N, Hammonds TR, Huber K, Muschel R, Borrow P, Cerundolo V, Kessler BM.
Pinto-Fernandez A, et al.
Br J Cancer. 2021 Feb;124(4):817-830. doi: 10.1038/s41416-020-01167-y. Epub 2020 Nov 20.
Br J Cancer. 2021.
PMID: 33214684
Free PMC article.
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USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
Rusilowicz-Jones EV, Jardine J, Kallinos A, Pinto-Fernandez A, Guenther F, Giurrandino M, Barone FG, McCarron K, Burke CJ, Murad A, Martinez A, Marcassa E, Gersch M, Buckmelter AJ, Kayser-Bricker KJ, Lamoliatte F, Gajbhiye A, Davis S, Scott HC, Murphy E, England K, Mortiboys H, Komander D, Trost M, Kessler BM, Ioannidis S, Ahlijanian MK, Urbé S, Clague MJ.
Rusilowicz-Jones EV, et al. Among authors: scott hc.
Life Sci Alliance. 2020 Jul 7;3(8):e202000768. doi: 10.26508/lsa.202000768. Print 2020 Aug.
Life Sci Alliance. 2020.
PMID: 32636217
Free PMC article.
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Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics.
Pinto-Fernández A, Davis S, Schofield AB, Scott HC, Zhang P, Salah E, Mathea S, Charles PD, Damianou A, Bond G, Fischer R, Kessler BM.
Pinto-Fernández A, et al. Among authors: scott hc.
Front Chem. 2019 Aug 29;7:592. doi: 10.3389/fchem.2019.00592. eCollection 2019.
Front Chem. 2019.
PMID: 31555637
Free PMC article.
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Targeted Mass Spectrometry Reveals Interferon-Dependent Eicosanoid and Fatty Acid Alterations in Chronic Myeloid Leukaemia.
Scott HC, Draganov SD, Yu Z, Kessler BM, Pinto-Fernández A.
Scott HC, et al.
Int J Mol Sci. 2023 Oct 24;24(21):15513. doi: 10.3390/ijms242115513.
Int J Mol Sci. 2023.
PMID: 37958498
Free PMC article.
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