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Showing results for hannan alter
Search for Hanan Alter instead (1 results)
The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.
Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV. Hannan FM, et al. Nat Rev Endocrinol. 2018 Dec;15(1):33-51. doi: 10.1038/s41574-018-0115-0. Nat Rev Endocrinol. 2018. PMID: 30443043 Free PMC article. Review.
The importance of the CaSR for these calcitropic processes is highlighted by loss-of-function and gain-of-function CaSR mutations that cause familial hypocalciuric hypercalcaemia and autosomal dominant hypocalcaemia, respectively, and also by the fact that alterations in p …
The importance of the CaSR for these calcitropic processes is highlighted by loss-of-function and gain-of-function CaSR mutations that cause …
Tumor loss-of-function mutations in STK11/LKB1 induce cachexia.
Iyengar P, Gandhi AY, Granados J, Guo T, Gupta A, Yu J, Llano EM, Zhang F, Gao A, Kandathil A, Williams D, Gao B, Girard L, Malladi VS, Shelton JM, Evers BM, Hannan R, Ahn C, Minna JD, Infante RE. Iyengar P, et al. JCI Insight. 2023 Apr 24;8(8):e165419. doi: 10.1172/jci.insight.165419. JCI Insight. 2023. PMID: 37092555 Free PMC article.
Silencing of STK11/LKB1 in human NSCLC and murine colorectal carcinoma lines conferred a cachexia phenotype after cell transplantation into immunodeficient (human NSCLC) and immunocompetent (murine colorectal carcinoma) models. This host wasting was associated with an alterati …
Silencing of STK11/LKB1 in human NSCLC and murine colorectal carcinoma lines conferred a cachexia phenotype after cell transplantation into …
Genetics of Skeletal Disorders.
Hannan FM, Newey PJ, Whyte MP, Thakker RV. Hannan FM, et al. Handb Exp Pharmacol. 2020;262:325-351. doi: 10.1007/164_2020_350. Handb Exp Pharmacol. 2020. PMID: 32166388 Review.
Bone and mineral diseases encompass a variety of conditions that involve altered skeletal homeostasis and are frequently associated with changes in circulating calcium, phosphate, or vitamin D metabolites. ...
Bone and mineral diseases encompass a variety of conditions that involve altered skeletal homeostasis and are frequently associated w …
Toxoplasmosis: A pathway to neuropsychiatric disorders.
Tyebji S, Seizova S, Hannan AJ, Tonkin CJ. Tyebji S, et al. Neurosci Biobehav Rev. 2019 Jan;96:72-92. doi: 10.1016/j.neubiorev.2018.11.012. Epub 2018 Nov 23. Neurosci Biobehav Rev. 2019. PMID: 30476506 Review.
Toxoplasma gondii is an obligate intracellular parasite that resides, in a latent form, in the human central nervous system. Infection with Toxoplasma drastically alters the behaviour of rodents and is associated with the incidence of specific neuropsychiatric conditions i …
Toxoplasma gondii is an obligate intracellular parasite that resides, in a latent form, in the human central nervous system. Infection with …
Multi-scale models of lung fibrosis.
Leonard-Duke J, Evans S, Hannan RT, Barker TH, Bates JHT, Bonham CA, Moore BB, Kirschner DE, Peirce SM. Leonard-Duke J, et al. Matrix Biol. 2020 Sep;91-92:35-50. doi: 10.1016/j.matbio.2020.04.003. Epub 2020 May 11. Matrix Biol. 2020. PMID: 32438056 Free PMC article. Review.
Accordingly, when homeostasis is disrupted by the excessive production of connective tissue, lung function deteriorates rapidly with grave consequences leading to chronic lung conditions such as pulmonary fibrosis. Understanding how pulmonary fibrosis develops and alters t …
Accordingly, when homeostasis is disrupted by the excessive production of connective tissue, lung function deteriorates rapidly with grave c …
Genetic approaches to metabolic bone diseases.
Hannan FM, Newey PJ, Whyte MP, Thakker RV. Hannan FM, et al. Br J Clin Pharmacol. 2019 Jun;85(6):1147-1160. doi: 10.1111/bcp.13803. Epub 2018 Nov 28. Br J Clin Pharmacol. 2019. PMID: 30357886 Free PMC article. Review.
Metabolic bone diseases comprise a diverse group of disorders characterized by alterations in skeletal homeostasis, and are often associated with abnormal circulating concentrations of calcium, phosphate or vitamin D metabolites. ...
Metabolic bone diseases comprise a diverse group of disorders characterized by alterations in skeletal homeostasis, and are often ass …
Bilayer Forming Phospholipids as Targets for Cancer Therapy.
Stoica C, Ferreira AK, Hannan K, Bakovic M. Stoica C, et al. Int J Mol Sci. 2022 May 9;23(9):5266. doi: 10.3390/ijms23095266. Int J Mol Sci. 2022. PMID: 35563655 Free PMC article. Review.
De novo biosynthesis of phosphatidylcholine and phosphatidylethanolamine occurs via the Kennedy pathway, and perturbations in the regulation of this pathway are linked to a variety of human diseases, including cancer. Altered phosphatidylcholine and phosphatidylethanolamin …
De novo biosynthesis of phosphatidylcholine and phosphatidylethanolamine occurs via the Kennedy pathway, and perturbations in the regulation …
GNA11 Variants Identified in Patients with Hypercalcemia or Hypocalcemia.
Howles SA, Gorvin CM, Cranston T, Rogers A, Gluck AK, Boon H, Gibson K, Rahman M, Root A, Nesbit MA, Hannan FM, Thakker RV. Howles SA, et al. J Bone Miner Res. 2023 Jun;38(6):907-917. doi: 10.1002/jbmr.4803. Epub 2023 Apr 18. J Bone Miner Res. 2023. PMID: 36970776 Free PMC article.
Three-dimensional homology modeling of the Val87 variant suggested it was likely benign, and expression of Val87 variant and wild-type Met87 Galpha11 in CaSR-expressing HEK293 cells revealed no differences in intracellular calcium responses to alterations in extracellular …
Three-dimensional homology modeling of the Val87 variant suggested it was likely benign, and expression of Val87 variant and wild-type Met87 …
Epigenetic modifications in trinucleotide repeat diseases.
Evans-Galea MV, Hannan AJ, Carrodus N, Delatycki MB, Saffery R. Evans-Galea MV, et al. Trends Mol Med. 2013 Nov;19(11):655-63. doi: 10.1016/j.molmed.2013.07.007. Epub 2013 Aug 14. Trends Mol Med. 2013. PMID: 23953480 Review.
Given the debilitating and sometimes fatal consequences of TNR disorders, understanding how an altered epigenetic profile impacts clinical outcome warrants further attention, and could provide key insights for developing novel epigenetic therapies and biomarkers. ...
Given the debilitating and sometimes fatal consequences of TNR disorders, understanding how an altered epigenetic profile impacts cli …
Psilocybin as a lead candidate molecule in preclinical therapeutic studies of psychiatric disorders: A systematic review.
Gattuso JJ, Wilson C, Hannan AJ, Renoir T. Gattuso JJ, et al. J Neurochem. 2023 Nov 29. doi: 10.1111/jnc.16017. Online ahead of print. J Neurochem. 2023. PMID: 38019032 Review.
Psilocybin has begun to show efficacy for a range of neuropsychiatric conditions, including treatment-resistant depression and anxiety disorders; however, neurobiological mechanisms are still being elucidated. Clinical research has found that psilocybin can alter functiona …
Psilocybin has begun to show efficacy for a range of neuropsychiatric conditions, including treatment-resistant depression and anxiety disor …
269 results