Hajime Takashima - Search Results

Year	Number of Results
2002	1
2003	2
2004	1
2020	2
2021	4
2022	5
2024	0

1

Visualized and Quantitative Conformational Analysis of Peptidomimetics.

Takashima H, Yoshimori A, Honda E, Taguri T, Ozawa J, Kasai M, Shuto S, Takehara D. Takashima H, et al. ACS Omega. 2021 Sep 27;6(40):26601-26612. doi: 10.1021/acsomega.1c03967. eCollection 2021 Oct 12. ACS Omega. 2021. PMID: 34661014 Free PMC article.

2

TP0586532, a non-hydroxamate LpxC inhibitor, has in vitro and in vivo antibacterial activities against Enterobacteriaceae.

Fujita K, Takata I, Yoshida I, Okumura H, Otake K, Takashima H, Sugiyama H. Fujita K, et al. Among authors: takashima h. J Antibiot (Tokyo). 2022 Feb;75(2):98-107. doi: 10.1038/s41429-021-00486-3. Epub 2021 Nov 26. J Antibiot (Tokyo). 2022. PMID: 34837061

3

Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532.

Ushiyama F, Takashima H, Matsuda Y, Ogata Y, Sasamoto N, Kurimoto-Tsuruta R, Ueki K, Tanaka-Yamamoto N, Endo M, Mima M, Fujita K, Takata I, Tsuji S, Yamashita H, Okumura H, Otake K, Sugiyama H. Ushiyama F, et al. Among authors: takashima h. Bioorg Med Chem. 2021 Jan 15;30:115964. doi: 10.1016/j.bmc.2020.115964. Epub 2020 Dec 29. Bioorg Med Chem. 2021. PMID: 33385955

4

Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity.

Yamada Y, Takashima H, Walmsley DL, Ushiyama F, Matsuda Y, Kanazawa H, Yamaguchi-Sasaki T, Tanaka-Yamamoto N, Yamagishi J, Kurimoto-Tsuruta R, Ogata Y, Ohtake N, Angove H, Baker L, Harris R, Macias A, Robertson A, Surgenor A, Watanabe H, Nakano K, Mima M, Iwamoto K, Okada A, Takata I, Hitaka K, Tanaka A, Fujita K, Sugiyama H, Hubbard RE. Yamada Y, et al. Among authors: takashima h. J Med Chem. 2020 Dec 10;63(23):14805-14820. doi: 10.1021/acs.jmedchem.0c01215. Epub 2020 Nov 19. J Med Chem. 2020. PMID: 33210531

5

Structural consideration of macrolide antibiotics in relation to the ribosomal interaction and drug design.

Takashima H. Takashima H. Curr Top Med Chem. 2003;3(9):991-9. doi: 10.2174/1568026033452177. Curr Top Med Chem. 2003. PMID: 12678833 Review.

6

Generalized-ensemble method study: A helix-mimetic compound inhibits protein-protein interaction by long-range and short-range intermolecular interactions.

Higo J, Takashima H, Fukunishi Y, Yoshimori A. Higo J, et al. Among authors: takashima h. J Comput Chem. 2021 May 30;42(14):956-969. doi: 10.1002/jcc.26516. Epub 2021 Mar 23. J Comput Chem. 2021. PMID: 33755222

7

Rational Strategy for Designing Peptidomimetic Small Molecules Based on Cyclic Peptides Targeting Protein-Protein Interaction between CTLA-4 and B7-1.

Tsuihiji K, Honda E, Kojoh K, Katoh S, Taguri T, Yoshimori A, Takashima H. Tsuihiji K, et al. Among authors: takashima h. Pharmaceuticals (Basel). 2022 Dec 2;15(12):1506. doi: 10.3390/ph15121506. Pharmaceuticals (Basel). 2022. PMID: 36558957 Free PMC article.

8

TP0586532, a non-hydroxamate LpxC inhibitor, reduces LPS release and IL-6 production both in vitro and in vivo.

Fujita K, Takata I, Yoshida I, Takashima H, Sugiyama H. Fujita K, et al. Among authors: takashima h. J Antibiot (Tokyo). 2022 Mar;75(3):136-145. doi: 10.1038/s41429-021-00498-z. Epub 2022 Jan 5. J Antibiot (Tokyo). 2022. PMID: 34987187 Free PMC article.

9

TP0586532, a Novel Non-Hydroxamate LpxC Inhibitor: Potentiating Effect on In Vitro Activity of Meropenem against Carbapenem-Resistant Enterobacteriaceae.

Yoshida I, Takata I, Fujita K, Takashima H, Sugiyama H. Yoshida I, et al. Among authors: takashima h. Microbiol Spectr. 2022 Jun 29;10(3):e0082822. doi: 10.1128/spectrum.00828-22. Epub 2022 Jun 1. Microbiol Spectr. 2022. PMID: 35647694 Free PMC article.

10

Pharmacodynamic target assessment and prediction of clinically effective dosing regimen of TP0586532, a novel non-hydroxamate LpxC inhibitor, using a murine lung infection model.

Fujita K, Takata I, Yoshida I, Honma Y, Okumura H, Otake K, Takashima H, Sugiyama H. Fujita K, et al. Among authors: takashima h. J Infect Chemother. 2022 May;28(5):635-642. doi: 10.1016/j.jiac.2022.01.004. Epub 2022 Feb 5. J Infect Chemother. 2022. PMID: 35131156

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