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Showing results for haemin zhai
Your search for Haimin Zhai retrieved no results
Identification of Cytoprotective Small-Molecule Inducers of Heme-Oxygenase-1.
Ghajar-Rahimi G, Traylor AM, Mathew B, Bostwick JR, Nebane NM, Zmijewska AA, Esman SK, Thukral S, Zhai L, Sambandam V, Cowell RM, Suto MJ, George JF, Augelli-Szafran CE, Agarwal A. Ghajar-Rahimi G, et al. Antioxidants (Basel). 2022 Sep 23;11(10):1888. doi: 10.3390/antiox11101888. Antioxidants (Basel). 2022. PMID: 36290611 Free PMC article.
Through cell-based, high-throughput screens for induction of HO-1 driven by the human HO-1 promoter/enhancer, we identified two novel small molecules and broxaldine (an FDA-approved drug) for further consideration as candidate compounds exhibiting an Emax 70% of 5 M hemin …
Through cell-based, high-throughput screens for induction of HO-1 driven by the human HO-1 promoter/enhancer, we identified two novel small …
Oxygen-boosted biomimetic nanoplatform for synergetic phototherapy/ferroptosis activation and reversal of immune-suppressed tumor microenvironment.
He Z, Zhou H, Zhang Y, Du X, Liu S, Ji J, Yang X, Zhai G. He Z, et al. Biomaterials. 2022 Nov;290:121832. doi: 10.1016/j.biomaterials.2022.121832. Epub 2022 Sep 29. Biomaterials. 2022. PMID: 36228518
To deal with these obstacles, a novel biomimetic nanoplatform is fabricated for the precise delivery of photosensitizer chlorin e6 (Ce6), hemin and PEP20 (CD47 inhibitory peptide), integrating oxygen-boosted PDT, ferroptosis activation and CD47-SIRPalpha blockade. Hemin …
To deal with these obstacles, a novel biomimetic nanoplatform is fabricated for the precise delivery of photosensitizer chlorin e6 (Ce6), …
Schistosoma japonicum: In vitro effects of artemether combined with haemin depend on cultivation media and appraisal of artemether products appearing in the media.
Xiao SH, Wu YL, Tanner M, Wu WM, Utzinger J, Mei JY, Scorneaux B, Chollet J, Zhai Z. Xiao SH, et al. Parasitol Res. 2003 Apr;89(6):459-66. doi: 10.1007/s00436-002-0786-1. Epub 2003 Jan 10. Parasitol Res. 2003. PMID: 12658457
We recently found that the exposure of schistosomes in vitro to artemether plus haemin can lead to parasite death, while exposure to each compound singly had no effect. ...Third, RPMI 1640 and HBSS media were supplemented with artemether and haemin in the presence o …
We recently found that the exposure of schistosomes in vitro to artemether plus haemin can lead to parasite death, while exposure to …
A Heme-Binding Transcription Factor BACH1 Regulates Lactate Catabolism Suggesting a Combined Therapy for Triple-Negative Breast Cancer.
Padilla J, Lee BS, Zhai K, Rentz B, Bobo T, Dowling NM, Lee J. Padilla J, et al. Cells. 2022 Mar 31;11(7):1177. doi: 10.3390/cells11071177. Cells. 2022. PMID: 35406740 Free PMC article.
Thus, small inhibitory molecules (SR13800 and AZD3965) blocking MCT1 better suppressed the growth of BACH1-depleted TNBC cells than did the controls. Particularly, hemin treatment degrading BACH1 proteins induced lactate catabolism in TNBC cells, generating synthetic letha …
Thus, small inhibitory molecules (SR13800 and AZD3965) blocking MCT1 better suppressed the growth of BACH1-depleted TNBC cells than did the …
Hemin blocks TIGIT/PVR interaction and induces ferroptosis to elicit synergistic effects of cancer immunotherapy.
Zhou X, Li Y, Zhang X, Li B, Jin S, Wu M, Zhou X, Dong Q, Du J, Zhai W, Wu Y, Qiu L, Li G, Qi Y, Zhao W, Gao Y. Zhou X, et al. Sci China Life Sci. 2024 Feb 1. doi: 10.1007/s11427-023-2472-4. Online ahead of print. Sci China Life Sci. 2024. PMID: 38324132
Hemin could effectively restore the IL-2 secretion from Jurkat-hTIGIT cells. Hemin reinvigorated the function of CD8(+) T cells to secrete IFN-gamma and the elevated IFN-gamma could synergize with Hemin to induce ferroptosis in tumor cells. ...
Hemin could effectively restore the IL-2 secretion from Jurkat-hTIGIT cells. Hemin reinvigorated the function of CD8(+) T cell …
A visual Hg2+ detection strategy based on distance as readout by G-quadruplex DNAzyme on microfluidic paper.
Wu C, Gao G, Zhai K, Xu L, Zhang D. Wu C, et al. Food Chem. 2020 Nov 30;331:127208. doi: 10.1016/j.foodchem.2020.127208. Epub 2020 Jun 3. Food Chem. 2020. PMID: 32554309
In this work, we have developed a simple, fast and visual Hg(2+) detection strategy based on distance as readout on paper chip by the Hg(2+)-mediated formation of G-quadruplex-hemin DNAzymes. In the presence of Hg(2+), the two oligonucleotides hybridize to form G-quadruple …
In this work, we have developed a simple, fast and visual Hg(2+) detection strategy based on distance as readout on paper chip by the Hg(2+) …
A novel aptasensor based on HCR and G-quadruplex DNAzyme for fluorescence detection of Carcinoembryonic Antigen.
Bai Y, Zhang H, Zhao L, Wang Y, Chen X, Zhai H, Tian M, Zhao R, Wang T, Xu H, Feng F. Bai Y, et al. Talanta. 2021 Jan 1;221:121451. doi: 10.1016/j.talanta.2020.121451. Epub 2020 Jul 28. Talanta. 2021. PMID: 33076074
In the presence of target CEA, the aptamer sequence in Aptamer Probe (AP) specifically bound to CEA, resulting in the AP conformation change and thus releasing initiator, which triggered the autonomous cross-opening of Hairpin 1 (H1) and Hairpin 2 (H2) that yielded extended nicke …
In the presence of target CEA, the aptamer sequence in Aptamer Probe (AP) specifically bound to CEA, resulting in the AP conformation change …
The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility.
Song J, Zhai P, Zhang Y, Zhang C, Sang H, Han G, Keller NP, Lu L. Song J, et al. mBio. 2016 Feb 23;7(1):e01919-15. doi: 10.1128/mBio.01919-15. mBio. 2016. PMID: 26908577 Free PMC article.
In contrast, overexpression of DapB and DapC causes dysfunction of Erg5 and Erg11, resulting in abnormal accumulation of sterol intermediates and further accentuating the sensitivity of deltadapA strains to azoles. The results of exogenous-hemin rescue and heme-binding-sit …
In contrast, overexpression of DapB and DapC causes dysfunction of Erg5 and Erg11, resulting in abnormal accumulation of sterol intermediate …
Hemin Improves Insulin Sensitivity and Lipid Metabolism in Cultured Hepatocytes and Mice Fed a High-Fat Diet.
Luan Y, Zhang F, Cheng Y, Liu J, Huang R, Yan M, Wang Y, He Z, Lai H, Wang H, Ying H, Guo F, Zhai Q. Luan Y, et al. Nutrients. 2017 Jul 26;9(8):805. doi: 10.3390/nu9080805. Nutrients. 2017. PMID: 28933767 Free PMC article.
Hemin is a breakdown product of hemoglobin. It has been reported that the injection of hemin improves lipid metabolism and insulin sensitivity in various genetic models. However, the effect of hemin supplementation in food on lipid metabolism and insulin sens …
Hemin is a breakdown product of hemoglobin. It has been reported that the injection of hemin improves lipid metabolism and ins …
16 results