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1995 1
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Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment.
Haake M, Haack B, Schäfer T, Harter PN, Mattavelli G, Eiring P, Vashist N, Wedekink F, Genssler S, Fischer B, Dahlhoff J, Mokhtari F, Kuzkina A, Welters MJP, Benz TM, Sorger L, Thiemann V, Almanzar G, Selle M, Thein K, Späth J, Gonzalez MC, Reitinger C, Ipsen-Escobedo A, Wistuba-Hamprecht K, Eichler K, Filipski K, Zeiner PS, Beschorner R, Goedemans R, Gogolla FH, Hackl H, Rooswinkel RW, Thiem A, Roche PR, Joshi H, Pühringer D, Wöckel A, Diessner JE, Rüdiger M, Leo E, Cheng PF, Levesque MP, Goebeler M, Sauer M, Nimmerjahn F, Schuberth-Wagner C, von Felten S, Mittelbronn M, Mehling M, Beilhack A, van der Burg SH, Riedel A, Weide B, Dummer R, Wischhusen J. Haake M, et al. Nat Commun. 2023 Jul 20;14(1):4253. doi: 10.1038/s41467-023-39817-3. Nat Commun. 2023. PMID: 37474523 Free PMC article.
Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity.
Kvitne KE, Krogstad V, Wegler C, Johnson LK, Kringen MK, Hovd MH, Hertel JK, Heijer M, Sandbu R, Skovlund E, Artursson P, Karlsson C, Andersson S, Andersson TB, Hjelmesaeth J, Åsberg A, Jansson-Löfmark R, Christensen H, Robertsen I. Kvitne KE, et al. Br J Clin Pharmacol. 2022 Sep;88(9):4121-4133. doi: 10.1111/bcp.15349. Epub 2022 Apr 25. Br J Clin Pharmacol. 2022. PMID: 35404513 Free PMC article. Clinical Trial.
The objective was to compare short- and long-term effects of RYGB and diet on the metabolic ratios of paraxanthine/caffeine (cytochrome P450 [CYP] 1A2 activity), 5-hydroxyomeprazole/omeprazole (CYP2C19 activity) and losartan/losartan carboxylic acid (CYP2C9 activity), and …
The objective was to compare short- and long-term effects of RYGB and diet on the metabolic ratios of paraxanthine/caffeine (cytochro …
Activation of skeletal ryanodine receptors by two novel scorpion toxins from Buthotus judaicus.
Zhu X, Zamudio FZ, Olbinski BA, Possani LD, Valdivia HH. Zhu X, et al. J Biol Chem. 2004 Jun 18;279(25):26588-96. doi: 10.1074/jbc.M403284200. Epub 2004 Apr 5. J Biol Chem. 2004. PMID: 15067003 Free article.
Their activating effect was Ca(2+)-dependent and was synergized by caffeine. B. judaicus toxins also increased binding of [(3)H]ryanodine to the purified RyR1, suggesting that a direct protein-protein interaction mediates the effect of the peptides. ...B., Arevalo, C., Sre …
Their activating effect was Ca(2+)-dependent and was synergized by caffeine. B. judaicus toxins also increased binding of [(3)H]ryano …
Constitutive Intracellular Na+ Excess in Purkinje Cells Promotes Arrhythmogenesis at Lower Levels of Stress Than Ventricular Myocytes From Mice With Catecholaminergic Polymorphic Ventricular Tachycardia.
Willis BC, Pandit SV, Ponce-Balbuena D, Zarzoso M, Guerrero-Serna G, Limbu B, Deo M, Camors E, Ramirez RJ, Mironov S, Herron TJ, Valdivia HH, Jalife J. Willis BC, et al. Circulation. 2016 Jun 14;133(24):2348-59. doi: 10.1161/CIRCULATIONAHA.116.021936. Epub 2016 May 11. Circulation. 2016. PMID: 27169737 Free PMC article.
As a result of increased activity of mutant ryanodine receptor type 2 channels, sarcoplasmic reticulum Ca(2+) load, measured by caffeine-induced Ca(2+) transients, was lower in CPVT VMs and PCs than respective controls, and sarcoplasmic reticulum fractional release was gre …
As a result of increased activity of mutant ryanodine receptor type 2 channels, sarcoplasmic reticulum Ca(2+) load, measured by caffeine …
Peptide probe of ryanodine receptor function. Imperatoxin A, a peptide from the venom of the scorpion Pandinus imperator, selectively activates skeletal-type ryanodine receptor isoforms.
el-Hayek R, Lokuta AJ, Arévalo C, Valdivia HH. el-Hayek R, et al. J Biol Chem. 1995 Dec 1;270(48):28696-704. doi: 10.1074/jbc.270.48.28696. J Biol Chem. 1995. PMID: 7499390 Free article.
We have used [3H]ryanodine binding experiments and single channel recordings to provide convergent descriptions of the effect of imperatoxin A (IpTxa), a approximately 5-kDa peptide from the venom of the scorpion Pandinus imperator (Valdivia, H. H., Kirby, M. S., Le …
We have used [3H]ryanodine binding experiments and single channel recordings to provide convergent descriptions of the effect of imperatoxin …
Microplasma discharge ionization source for ambient mass spectrometry.
Symonds JM, Galhena AS, Fernández FM, Orlando TM. Symonds JM, et al. Anal Chem. 2010 Jan 15;82(2):621-7. doi: 10.1021/ac901964m. Anal Chem. 2010. PMID: 20020764
The initial performance of the microplasma device has been evaluated by ionizing samples containing dimethyl sulfoxide (DMSO), dimethylformamide (DMF), methyl salicylate, caffeine, l-leucine, l-histidine, loratadine, ibuprofen, acetaminophen, acetylsalicylic acid, and coca …
The initial performance of the microplasma device has been evaluated by ionizing samples containing dimethyl sulfoxide (DMSO), dimethylforma …