Selective Probing of the Penetration of Dexamethasone into Human Skin by Soft X-ray Spectromicroscopy.
Yamamoto K, Flesch R, Ohigashi T, Hedtrich S, Klossek A, Patoka P, Ulrich G, Ahlberg S, Rancan F, Vogt A, Blume-Peytavi U, Schrade P, Bachmann S, Schäfer-Korting M, Kosugi N, Rühl E.
Yamamoto K, et al.
Anal Chem. 2015 Jun 16;87(12):6173-9. doi: 10.1021/acs.analchem.5b00800. Epub 2015 May 26.
Anal Chem. 2015.
PMID: 25942614
The key of this work is to probe dexamethasone selectively at the carbonyl site (C3) by the O 1s pi* transition, providing also a most efficient way to quantify the drug concentration as a function of penetration depth in correlation with structural properties of the skin contain …
The key of this work is to probe dexamethasone selectively at the carbonyl site (C3) by the O 1s pi* transition, providing also a most effic …