Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.
Demoro B, Caruso F, Rossi M, Benítez D, González M, Cerecetto H, Galizzi M, Malayil L, Docampo R, Faccio R, Mombrú AW, Gambino D, Otero L.
Demoro B, et al.
Dalton Trans. 2012 Jun 7;41(21):6468-76. doi: 10.1039/c2dt12179d. Epub 2012 Feb 17.
Dalton Trans. 2012.
PMID: 22344249
In the search for a pharmacological answer to treat Chagas disease, eight metal complexes with two bioactive bisphosphonates, alendronate (Ale) and pamidronate (Pam), were described. Complexes of the formula [M(2)(II)(Ale)(4)(H(2)O)(2)].2H(2)O, with M = Cu, Co, Mn, Ni, and …
In the search for a pharmacological answer to treat Chagas disease, eight metal complexes with two bioactive bisphosphonates, alendronate (A …