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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
2005 2
2006 2
2007 4
2008 3
2009 1
2010 3
2011 1
2012 4
2013 1
2014 1
2015 3
2016 3
2017 2
2019 2
2020 1
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2023 2
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33 results

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Page 1
Metastatic and non-metastatic melanoma imaging using Sgc8-c aptamer PTK7-recognizer.
Sicco E, Mónaco A, Fernandez M, Moreno M, Calzada V, Cerecetto H. Sicco E, et al. Sci Rep. 2021 Oct 7;11(1):19942. doi: 10.1038/s41598-021-98828-6. Sci Rep. 2021. PMID: 34620894 Free PMC article.
In addition, they have rapid clearance from blood exhibiting excellent target (tumor)/non-target organ ratios. Furthermore, optimal biodistribution was observed 24 h after probes injections accumulating almost exclusively in the tumor tissue. ...
In addition, they have rapid clearance from blood exhibiting excellent target (tumor)/non-target organ ratios. Furthermore, optimal biodistr …
Tautomerism and Rotamerism of Favipiravir and Halogenated Analogues in Solution and in the Solid State.
Romero AH, Fuentes G, Suescun L, Piro O, Echeverría G, Gotopo L, Pezaroglo H, Álvarez G, Cabrera G, Cerecetto H, Couto M. Romero AH, et al. J Org Chem. 2023 Aug 4;88(15):10735-10752. doi: 10.1021/acs.joc.3c00777. Epub 2023 Jul 15. J Org Chem. 2023. PMID: 37452781
Herein, the tautomeric 3-hydroxypyrazine/3-pyrazinone pair of favipiravir and its 6-substituted analogues, 6-Cl, 6-Br, 6-I, and 6-H, were fully investigated in solution and in the solid state through ultraviolet-visible, (1)H nuclear magnetic resonance, infrared spe …
Herein, the tautomeric 3-hydroxypyrazine/3-pyrazinone pair of favipiravir and its 6-substituted analogues, 6-Cl, 6-Br, 6-I, and 6-H, …
Exploring the cell death mechanisms of cytotoxic [1,2,3]triazolylcarborane lead compounds against U87 MG human glioblastoma cells.
Alamón C, Dávila B, Cerecetto H, Couto M. Alamón C, et al. Chem Biol Drug Des. 2023 Jun;101(6):1435-1445. doi: 10.1111/cbdd.14208. Epub 2023 Feb 15. Chem Biol Drug Des. 2023. PMID: 36746676
For that, we performed in U87 MG cells, flow cytometry experiments, as the gold standard technique, as well as confocal microscopy and (1) H-NMR experiments as non-invasive assays. We selected three hybrid leads (1-3) from the in-house-library and the corresponding parent …
For that, we performed in U87 MG cells, flow cytometry experiments, as the gold standard technique, as well as confocal microscopy and (1) …
3-(Benzyloxy)-1-(5-[18F]fluoropentyl)-5-nitro-1H-indazole: a PET radiotracer to measure acetylcholinesterase in brain.
Fernández S, Giglio J, Reyes AL, Damián A, Pérez C, Pérez DI, González M, Oliver P, Rey A, Engler H, Cerecetto H. Fernández S, et al. Future Med Chem. 2017 Jun;9(10):983-994. doi: 10.4155/fmc-2017-0023. Epub 2017 Jun 20. Future Med Chem. 2017. PMID: 28632402
RESULTS: [(18)F]-IND1 was obtained in good radiochemical yield, was stable for at least 2 h in different conditions, and had adequate lipophilicity for blood-brain barrier penetration. Biodistribution studies, in normal mice, showed that [(18)F]-IND1 was retained in the br …
RESULTS: [(18)F]-IND1 was obtained in good radiochemical yield, was stable for at least 2 h in different conditions, and had adequate …
Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.
Demoro B, Caruso F, Rossi M, Benítez D, González M, Cerecetto H, Galizzi M, Malayil L, Docampo R, Faccio R, Mombrú AW, Gambino D, Otero L. Demoro B, et al. Dalton Trans. 2012 Jun 7;41(21):6468-76. doi: 10.1039/c2dt12179d. Epub 2012 Feb 17. Dalton Trans. 2012. PMID: 22344249
In the search for a pharmacological answer to treat Chagas disease, eight metal complexes with two bioactive bisphosphonates, alendronate (Ale) and pamidronate (Pam), were described. Complexes of the formula [M(2)(II)(Ale)(4)(H(2)O)(2)].2H(2)O, with M = Cu, Co, Mn, Ni, and …
In the search for a pharmacological answer to treat Chagas disease, eight metal complexes with two bioactive bisphosphonates, alendronate (A …
Sgc8-c Aptamer as a Potential Theranostic Agent for Hemato-Oncological Malignancies.
Sicco E, Baez J, Ibarra M, Fernández M, Cabral P, Moreno M, Cerecetto H, Calzada V. Sicco E, et al. Cancer Biother Radiopharm. 2020 May;35(4):262-270. doi: 10.1089/cbr.2019.3402. Cancer Biother Radiopharm. 2020. PMID: 32407201
Results: The biodistribution results showed considerable uptake in tumor since 2 h, with highest at 48 h postinjection. However, the blood and muscle ID/g (injected dose per gram of tissue) activities were decreasing with time and tumor/no-target ratios increasing t …
Results: The biodistribution results showed considerable uptake in tumor since 2 h, with highest at 48 h postinjection. Howeve …
Analgesic and Anti-Inflammatory Properties of Arylnitroalkenes.
Celano L, Cupertino Da Silva YK, Cataldo N, Gabay M, Merlino A, Alexandre-Moreira MS, Lima LM, Cerecetto H, González M, Thomson L. Celano L, et al. Inflamm Allergy Drug Targets. 2015;14(1):19-28. doi: 10.2174/1871528114666151022145930. Inflamm Allergy Drug Targets. 2015. PMID: 26490661
The pharmacological effects were consistent with the inhibitory effect observed on prostaglandin endoperoxide H synthase (PGHS). In fact, both PGHS-1 and PGHS-2 were inhibited by the compounds, with compound 2 being more specific as PGHS-2 inhibitor with a specificity inde …
The pharmacological effects were consistent with the inhibitory effect observed on prostaglandin endoperoxide H synthase (PGHS). In f …
Risedronate metal complexes potentially active against Chagas disease.
Demoro B, Caruso F, Rossi M, Benítez D, Gonzalez M, Cerecetto H, Parajón-Costa B, Castiglioni J, Galizzi M, Docampo R, Otero L, Gambino D. Demoro B, et al. J Inorg Biochem. 2010 Dec;104(12):1252-8. doi: 10.1016/j.jinorgbio.2010.08.004. Epub 2010 Aug 14. J Inorg Biochem. 2010. PMID: 20817265 Free PMC article.
In the search for new metal-based drugs for the treatment of Chagas disease, the most widespread Latin American parasitic disease, novel complexes of the bioactive ligand risedronate (Ris, (1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonate), [M(II)(Ris)(2)].4H(2)O, where MCu …
In the search for new metal-based drugs for the treatment of Chagas disease, the most widespread Latin American parasitic disease, novel com …
33 results