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Respiratory virus detection in returning travelers and pilgrims from the Middle East.
Mercier A, Méheut A, Alidjinou EK, Lazrek M, Faure K, Hober D, Engelmann I. Mercier A, et al. Travel Med Infect Dis. 2023 Jan-Feb;51:102482. doi: 10.1016/j.tmaid.2022.102482. Epub 2022 Oct 21. Travel Med Infect Dis. 2023. PMID: 36280020 Free PMC article.
Most frequently detected viruses were Enterovirus/Rhinovirus (40/83; 48.2%), Influenzavirus A (34/90; 37.8%) and B (11/90; 12.2%), H-CoV (229E and OC43 10/83; 12% and 7/83; 8.4%, respectively). ...
Most frequently detected viruses were Enterovirus/Rhinovirus (40/83; 48.2%), Influenzavirus A (34/90; 37.8%) and B (11/90; 12.2%), …
Design, synthesis, and molecular modeling studies of novel 2-quinolone-1,2,3-triazole-α-aminophosphonates hybrids as dual antiviral and antibacterial agents.
Gadali KE, Rafya M, El Mansouri AE, Maatallah M, Vanderlee A, Mehdi A, Neyts J, Jochmans D, De Jonghe S, Benkhalti F, Sanghvi YS, Taourirte M, Lazrek HB. Gadali KE, et al. Eur J Med Chem. 2024 Mar 15;268:116235. doi: 10.1016/j.ejmech.2024.116235. Epub 2024 Feb 16. Eur J Med Chem. 2024. PMID: 38377828 Review.
With the aim to identify new antiviral agents with antibacterial properties, a series of 2-quinolone-1,2,3-triazole derivatives bearing alpha-aminophosphonates was synthesized and characterized by (1)H NMR, (13)C NMR, (31)P NMR, single crystal XRD and HRMS analyses. ...
With the aim to identify new antiviral agents with antibacterial properties, a series of 2-quinolone-1,2,3-triazole derivatives bearing alph …
Synthesis, characterization, molecular docking, and anticancer activities of new 1,3,4-oxadiazole-5-fluorocytosine hybrid derivatives.
El Mansouri AE, Lachhab S, Oubella A, Ahmad M, Neyts J, Jochmans D, Chiu W, Vangeel L, De Jonghe S, Morjani H, Ali MA, Zahouily M, Sanghvi YS, Lazrek HB. El Mansouri AE, et al. J Mol Struct. 2022 Sep 9:134135. doi: 10.1016/j.molstruc.2022.134135. Online ahead of print. J Mol Struct. 2022. PMID: 36101881 Free PMC article.
Herein, we present a new design for 5-fluorocytosine-1,3,4-oxadiazole hybrids (5a-h) connected via a methylene bridge. An efficient synthesis of new derivatives was established, and all compounds were fully characterized by NMR and MS. ...
Herein, we present a new design for 5-fluorocytosine-1,3,4-oxadiazole hybrids (5a-h) connected via a methylene bridge. An efficient s …
Crystal structure of 2-benzamido-N-(2,2-di-eth-oxy-eth-yl)benzamide.
Ouahrouch A, Taourirte M, Lazrek HB, Engels JW, Bolte M. Ouahrouch A, et al. Acta Crystallogr E Crystallogr Commun. 2015 Feb 28;71(Pt 3):o214-5. doi: 10.1107/S2056989015003370. eCollection 2015 Mar 1. Acta Crystallogr E Crystallogr Commun. 2015. PMID: 25844255 Free PMC article.
In the title compound, C20H24N2O4, both peptide bonds adopt a trans configuration with respect to the -N-H and -C=O groups. The dihedral angle between the aromatic rings is 53.58 (4). ...The crystal packing is characterized by zigzag chains of N-HO hydrogen-bonded mol-ecul …
In the title compound, C20H24N2O4, both peptide bonds adopt a trans configuration with respect to the -N-H and -C=O groups. The dihed …
Synthesis and biological activity of 4-substituted 1-[1-(2-hydroxyethoxy)-methyl-1,2,3-triazol-(4 & 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines.
Moukha-Chafiq O, Taha ML, Lazrek HB, Pannecouque C, Witvrouw M, De Clercq E, Barascut JL, Imbach JL. Moukha-Chafiq O, et al. Nucleosides Nucleotides Nucleic Acids. 2001 Oct-Nov;20(10-11):1797-810. doi: 10.1081/NCN-100107191. Nucleosides Nucleotides Nucleic Acids. 2001. PMID: 11719993
The chemical synthesis of some 4-substituted 1-[1-(2-hydroxyethoxy)-methyl-1,2.3-triazol-(4 and 5)-ylmethyl]-1-H-pyrazolo[3,4-d]pyrimidines 12a,b, 13a,b and 14-23 as acyclic nucleosides is described. ...No marked activity was found. However, initial evaluatio …
The chemical synthesis of some 4-substituted 1-[1-(2-hydroxyethoxy)-methyl-1,2.3-triazol-(4 and 5)-ylmethyl]-1-H-pyrazolo[3,4-d]pyrim …