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S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling.
Ko Y, Hong M, Lee S, Kumar M, Ibrahim L, Nutsch K, Stanton C, Sondermann P, Sandoval B, Bulos ML, Iaconelli J, Chatterjee AK, Wiseman RL, Schultz PG, Bollong MJ. Ko Y, et al. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2300763120. doi: 10.1073/pnas.2300763120. Epub 2023 May 8. Proc Natl Acad Sci U S A. 2023. PMID: 37155889 Free PMC article.
pH-dependent structural transitions in cationic ionizable lipid mesophases are critical for lipid nanoparticle function.
Philipp J, Dabkowska A, Reiser A, Frank K, Krzysztoń R, Brummer C, Nickel B, Blanchet CE, Sudarsan A, Ibrahim M, Johansson S, Skantze P, Skantze U, Östman S, Johansson M, Henderson N, Elvevold K, Smedsrød B, Schwierz N, Lindfors L, Rädler JO. Philipp J, et al. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2310491120. doi: 10.1073/pnas.2310491120. Epub 2023 Dec 6. Proc Natl Acad Sci U S A. 2023. PMID: 38055742 Free PMC article.
CRY2 missense mutations suppress P53 and enhance cell growth.
Chan AB, Parico GCG, Fribourgh JL, Ibrahim LH, Bollong MJ, Partch CL, Lamia KA. Chan AB, et al. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2101416118. doi: 10.1073/pnas.2101416118. Proc Natl Acad Sci U S A. 2021. PMID: 34183418 Free PMC article.
In silico screening and epitope mapping of leptospiral outer membrane protein-Lsa46.
Ibrahim JM, A S, Nair AS, Oommen OV, Sudhakaran PR. Ibrahim JM, et al. J Biomol Struct Dyn. 2023 Jan;41(1):26-44. doi: 10.1080/07391102.2021.2003247. Epub 2021 Nov 25. J Biomol Struct Dyn. 2023. PMID: 34821205
The results of the study help in elucidating the structural and functional characterization of Lsa46 for epitope-based vaccine design.Communicated by Ramaswamy H. Sarma....
The results of the study help in elucidating the structural and functional characterization of Lsa46 for epitope-based vaccine design.Commun …
FcalphaRI binding at the IgA1 C(H)2-C(H)3 interface induces long-range conformational changes that are transmitted to the hinge region.
Posgai MT, Tonddast-Navaei S, Jayasinghe M, Ibrahim GM, Stan G, Herr AB. Posgai MT, et al. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8882-E8891. doi: 10.1073/pnas.1807478115. Epub 2018 Sep 4. Proc Natl Acad Sci U S A. 2018. PMID: 30181292 Free PMC article.
IgA effector functions include proinflammatory immune responses triggered upon clustering of the IgA-specific receptor, FcalphaRI, by IgA immune complexes. FcalphaRI binds to the IgA1-Fc domain (Fcalpha) at the C(H)2-C(H)3 junction and, except for C(H)2 L257 …
IgA effector functions include proinflammatory immune responses triggered upon clustering of the IgA-specific receptor, FcalphaRI, by IgA im …
Intestinal microbes influence development of thymic lymphocytes in early life.
Ennamorati M, Vasudevan C, Clerkin K, Halvorsen S, Verma S, Ibrahim S, Prosper S, Porter C, Yeliseyev V, Kim M, Gardecki J, Sassi S, Tearney G, Cherayil BJ, Bry L, Seed B, Jain N. Ennamorati M, et al. Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2570-2578. doi: 10.1073/pnas.1915047117. Epub 2020 Jan 21. Proc Natl Acad Sci U S A. 2020. PMID: 31964813 Free PMC article.
A yeast functional screen predicts new candidate ALS disease genes.
Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Solski JA, Williams KL, Mojsilovic-Petrovic J, Ingre C, Boylan K, Graff-Radford NR, Dickson DW, Clay-Falcone D, Elman L, McCluskey L, Greene R, Kalb RG, Lee VM, Trojanowski JQ, Ludolph A, Robberecht W, Andersen PM, Nicholson GA, Blair IP, King OD, Bonini NM, Van Deerlin V, Rademakers R, Mourelatos Z, Gitler AD. Couthouis J, et al. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20881-90. doi: 10.1073/pnas.1109434108. Epub 2011 Nov 7. Proc Natl Acad Sci U S A. 2011. PMID: 22065782 Free PMC article.
Untangling the sequence of events during the S2 → S3 transition in photosystem II and implications for the water oxidation mechanism.
Ibrahim M, Fransson T, Chatterjee R, Cheah MH, Hussein R, Lassalle L, Sutherlin KD, Young ID, Fuller FD, Gul S, Kim IS, Simon PS, de Lichtenberg C, Chernev P, Bogacz I, Pham CC, Orville AM, Saichek N, Northen T, Batyuk A, Carbajo S, Alonso-Mori R, Tono K, Owada S, Bhowmick A, Bolotovsky R, Mendez D, Moriarty NW, Holton JM, Dobbek H, Brewster AS, Adams PD, Sauter NK, Bergmann U, Zouni A, Messinger J, Kern J, Yachandra VK, Yano J. Ibrahim M, et al. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12624-12635. doi: 10.1073/pnas.2000529117. Epub 2020 May 20. Proc Natl Acad Sci U S A. 2020. PMID: 32434915 Free PMC article.
At the electron acceptor site, changes due to the two-electron redox chemistry at the quinones, Q(A) and Q(B), are observed. At the donor site, tyrosine Y(Z) and His190 H-bonded to it move by 50 s after the second flash, and Glu189 moves away from Ca. This is followed by M …
At the electron acceptor site, changes due to the two-electron redox chemistry at the quinones, Q(A) and Q(B), are observed. At the donor si …
54 results