The vast body of literature regarding human telomere maintenance is a true testament to the importance of understanding telomere regulation in both normal and diseased states. In this review, our goal was simple: tell the telomerase story from the biogenesis of its parts to its maturity as a complex and function at its site of action, emphasizing new developments and how they contribute to the foundational knowledge of telomerase and telomere biology.
Keywords: H/ACA ribonucleoprotein; exosome; small Cajal body RNA; small nucleolar RNA; spliceosome; telomerase; telomere.