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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1998 1
1999 2
2000 1
2001 3
2002 2
2003 3
2004 2
2005 1
2006 10
2007 3
2008 7
2009 9
2010 12
2011 15
2012 18
2013 23
2014 56
2015 71
2016 64
2017 74
2018 82
2019 97
2020 94
2021 92
2022 69
2023 97
2024 38

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847 results

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Page 1
Showing results for helene drives
Your search for Hélène Brives retrieved no results
Systemic immunity in cancer.
Hiam-Galvez KJ, Allen BM, Spitzer MH. Hiam-Galvez KJ, et al. Nat Rev Cancer. 2021 Jun;21(6):345-359. doi: 10.1038/s41568-021-00347-z. Epub 2021 Apr 9. Nat Rev Cancer. 2021. PMID: 33837297 Free PMC article. Review.
Therefore, an improved understanding of tumour immunology must assess the systemic immune landscape beyond the tumour microenvironment (TME). Importantly, the peripheral immune system is required to drive effective natural and therapeutically induced antitumour immune resp …
Therefore, an improved understanding of tumour immunology must assess the systemic immune landscape beyond the tumour microenvironment (TME) …
Microglial NF-kappaB drives tau spreading and toxicity in a mouse model of tauopathy.
Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y, Condello C, Grinberg LT, Seeley WW, Miller BL, Mok SA, Gestwicki JE, Cuervo AM, Luo W, Gan L. Wang C, et al. Nat Commun. 2022 Apr 12;13(1):1969. doi: 10.1038/s41467-022-29552-6. Nat Commun. 2022. PMID: 35413950 Free PMC article.
Here we show that nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling, activated by tau, drives microglial-mediated tau propagation and toxicity. Constitutive activation of microglial NF-kappaB exacerbated, while inactivation diminished, ta …
Here we show that nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling, activated by tau, drives micr …
Fibrosis and cancer: A strained relationship.
Piersma B, Hayward MK, Weaver VM. Piersma B, et al. Biochim Biophys Acta Rev Cancer. 2020 Apr;1873(2):188356. doi: 10.1016/j.bbcan.2020.188356. Epub 2020 Mar 5. Biochim Biophys Acta Rev Cancer. 2020. PMID: 32147542 Free PMC article. Review.
Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma enhances tumor cell growth, survival and migration and drives a mesenchymal transi …
Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-linking that drive fibrosis to stiffen the s …
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Hüttenhain R, Kauwe G, Mercedes M, Sweetland-Martin L, Chen X, Mok SA, Wong MY, Telpoukhovskaia M, Min SW, Wang C, Sohn PD, Martin J, Zhou Y, Luo W, Trojanowski JQ, Lee VMY, Gong S, Manfredi G, Coppola G, Krogan NJ, Geschwind DH, Gan L. Tracy TE, et al. Cell. 2022 Feb 17;185(4):712-728.e14. doi: 10.1016/j.cell.2021.12.041. Epub 2022 Jan 20. Cell. 2022. PMID: 35063084 Free PMC article.
Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies. ...
Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies. ...
Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia.
Montefiori LE, Bendig S, Gu Z, Chen X, Pölönen P, Ma X, Murison A, Zeng A, Garcia-Prat L, Dickerson K, Iacobucci I, Abdelhamed S, Hiltenbrand R, Mead PE, Mehr CM, Xu B, Cheng Z, Chang TC, Westover T, Ma J, Stengel A, Kimura S, Qu C, Valentine MB, Rashkovan M, Luger S, Litzow MR, Rowe JM, den Boer ML, Wang V, Yin J, Kornblau SM, Hunger SP, Loh ML, Pui CH, Yang W, Crews KR, Roberts KG, Yang JJ, Relling MV, Evans WE, Stock W, Paietta EM, Ferrando AA, Zhang J, Kern W, Haferlach T, Wu G, Dick JE, Klco JM, Haferlach C, Mullighan CG. Montefiori LE, et al. Cancer Discov. 2021 Nov;11(11):2846-2867. doi: 10.1158/2159-8290.CD-21-0145. Epub 2021 Jun 8. Cancer Discov. 2021. PMID: 34103329 Free PMC article.
Chromatin conformation analyses demonstrated long-range interactions of rearranged enhancers with the expressed BCL11B allele and association of BCL11B with activated hematopoietic progenitor cell cis-regulatory elements, suggesting BCL11B is aberrantly co-opted into a gene regul …
Chromatin conformation analyses demonstrated long-range interactions of rearranged enhancers with the expressed BCL11B allele and associatio …
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF(V600E) colorectal tumors.
Ruiz-Saenz A, Atreya CE, Wang C, Pan B, Dreyer CA, Brunen D, Prahallad A, Muñoz DP, Ramms DJ, Burghi V, Spassov DS, Fewings E, Hwang YC, Cowdrey C, Moelders C, Schwarzer C, Wolf DM, Hann B, VandenBerg SR, Shokat K, Moasser MM, Bernards R, Gutkind JS, van 't Veer LJ, Coppé JP. Ruiz-Saenz A, et al. Nat Cancer. 2023 Feb;4(2):240-256. doi: 10.1038/s43018-022-00508-5. Epub 2023 Feb 9. Nat Cancer. 2023. PMID: 36759733 Free PMC article.
Here we show that SRC kinases are systematically activated in BRAF(V600E) CRC following targeted inhibition of BRAF EGFR and that coordinated targeting of SRC with BRAF EGFR increases treatment efficacy in vitro and in vivo. SRC drives resistance to BRAF EGFR targeted ther …
Here we show that SRC kinases are systematically activated in BRAF(V600E) CRC following targeted inhibition of BRAF EGFR and that coordinate …
Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium.
Jardé T, Chan WH, Rossello FJ, Kaur Kahlon T, Theocharous M, Kurian Arackal T, Flores T, Giraud M, Richards E, Chan E, Kerr G, Engel RM, Prasko M, Donoghue JF, Abe SI, Phesse TJ, Nefzger CM, McMurrick PJ, Powell DR, Daly RJ, Polo JM, Abud HE. Jardé T, et al. Cell Stem Cell. 2020 Oct 1;27(4):646-662.e7. doi: 10.1016/j.stem.2020.06.021. Epub 2020 Jul 20. Cell Stem Cell. 2020. PMID: 32693086 Free article.
Here, we identified neuregulin 1 (NRG1) as a key EGF family ligand that drives tissue repair following injury. NRG1, but not EGF, is upregulated upon damage and is expressed in mesenchymal stromal cells, macrophages, and Paneth cells. ...
Here, we identified neuregulin 1 (NRG1) as a key EGF family ligand that drives tissue repair following injury. NRG1, but not EGF, is …
Pain modulates dopamine neurons via a spinal-parabrachial-mesencephalic circuit.
Yang H, de Jong JW, Cerniauskas I, Peck JR, Lim BK, Gong H, Fields HL, Lammel S. Yang H, et al. Nat Neurosci. 2021 Oct;24(10):1402-1413. doi: 10.1038/s41593-021-00903-8. Epub 2021 Aug 9. Nat Neurosci. 2021. PMID: 34373644 Free PMC article.
LPB-targeted and nociception-recipient SNR neurons regulate VTA DA activity directly through feed-forward inhibition and indirectly by inhibiting a distinct subpopulation of VTA-projecting LPB neurons thereby reducing excitatory drive onto VTA DA neurons. Correspondingly, …
LPB-targeted and nociception-recipient SNR neurons regulate VTA DA activity directly through feed-forward inhibition and indirectly by inhib …
Synthetic lethality as an engine for cancer drug target discovery.
Huang A, Garraway LA, Ashworth A, Weber B. Huang A, et al. Nat Rev Drug Discov. 2020 Jan;19(1):23-38. doi: 10.1038/s41573-019-0046-z. Epub 2019 Nov 11. Nat Rev Drug Discov. 2020. PMID: 31712683 Review.
Although synthetic lethality is not a new idea, recent advances, including CRISPR-based gene editing, have made possible systematic screens for synthetic lethal drug targets in human cancers. Such approaches have broad potential to drive the discovery of the next wave of g …
Although synthetic lethality is not a new idea, recent advances, including CRISPR-based gene editing, have made possible systematic screens …
Vision-dependent specification of cell types and function in the developing cortex.
Cheng S, Butrus S, Tan L, Xu R, Sagireddy S, Trachtenberg JT, Shekhar K, Zipursky SL. Cheng S, et al. Cell. 2022 Jan 20;185(2):311-327.e24. doi: 10.1016/j.cell.2021.12.022. Cell. 2022. PMID: 35063073 Free PMC article.
We explore this in the mouse primary visual cortex (V1) using single-nucleus RNA sequencing, visual deprivation, genetics, and functional imaging. We find that vision selectively drives the specification of glutamatergic cell types in upper layers (L) (L2/3/4), while deepe …
We explore this in the mouse primary visual cortex (V1) using single-nucleus RNA sequencing, visual deprivation, genetics, and functional im …
847 results