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Page 1
Showing results for gustavo target
Search for Gustavo Taret instead (3 results)
Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response.
Snyder NA, Silva GM. Snyder NA, et al. J Biol Chem. 2021 Sep;297(3):101077. doi: 10.1016/j.jbc.2021.101077. Epub 2021 Aug 12. J Biol Chem. 2021. PMID: 34391779 Free PMC article. Review.
Due to their selectivity and functional roles, DUBs have become important targets for therapeutic development to treat these conditions. This review will discuss the main classes of DUBs and their regulatory mechanisms with a particular focus on DUB redox regulation and it …
Due to their selectivity and functional roles, DUBs have become important targets for therapeutic development to treat these conditio …
Cognitive biases associated with medical decisions: a systematic review.
Saposnik G, Redelmeier D, Ruff CC, Tobler PN. Saposnik G, et al. BMC Med Inform Decis Mak. 2016 Nov 3;16(1):138. doi: 10.1186/s12911-016-0377-1. BMC Med Inform Decis Mak. 2016. PMID: 27809908 Free PMC article. Review.
Of two (10 %) studies evaluating the impact of cognitive biases or personality traits on patient outcomes, only one showed that higher tolerance to ambiguity was associated with increased medical complications (9.7 % vs 6.5 %; p = .004). Most studies (60 %) targeted cognit …
Of two (10 %) studies evaluating the impact of cognitive biases or personality traits on patient outcomes, only one showed that higher toler …
Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons.
Nagy C, Maitra M, Tanti A, Suderman M, Théroux JF, Davoli MA, Perlman K, Yerko V, Wang YC, Tripathy SJ, Pavlidis P, Mechawar N, Ragoussis J, Turecki G. Nagy C, et al. Nat Neurosci. 2020 Jun;23(6):771-781. doi: 10.1038/s41593-020-0621-y. Epub 2020 Apr 27. Nat Neurosci. 2020. PMID: 32341540
These results highlight the importance of dissecting cell-type-specific contributions to the disease and offer opportunities to identify new avenues of research and novel targets for treatment....
These results highlight the importance of dissecting cell-type-specific contributions to the disease and offer opportunities to identify new …
Exercise as a Therapeutic Tool in Age-Related Frailty and Cardiovascular Disease: Challenges and Strategies.
Vazquez-Guajardo M, Rivas D, Duque G. Vazquez-Guajardo M, et al. Can J Cardiol. 2024 Jan 10:S0828-282X(24)00013-8. doi: 10.1016/j.cjca.2024.01.005. Online ahead of print. Can J Cardiol. 2024. PMID: 38215969 Free article. Review.
In addition, exercise is a vital tool that improves function, targets frailty, and holistically affects the body's systems. Still, many frail people do not exercise enough, and when they do, they usually do not follow an appropriate plan tailored for better functional outc …
In addition, exercise is a vital tool that improves function, targets frailty, and holistically affects the body's systems. Still, ma …
Liver-directed drugs for transthyretin-mediated amyloidosis.
Brannagan TH 3rd, Berk JL, Gillmore JD, Maurer MS, Waddington-Cruz M, Fontana M, Masri A, Obici L, Brambatti M, Baker BF, Hannan LA, Buchele G, Viney NJ, Coelho T, Nativi-Nicolau J. Brannagan TH 3rd, et al. J Peripher Nerv Syst. 2022 Dec;27(4):228-237. doi: 10.1111/jns.12519. Epub 2022 Nov 16. J Peripher Nerv Syst. 2022. PMID: 36345805 Free PMC article. Review.
One strategy to treat ATTR amyloidosis is to reduce the amount of TTR produced by the liver using drugs that directly target the TTR mRNA or gene. This narrative review focuses on how TTR gene silencing tools act to reduce TTR production, describing strategies for improved …
One strategy to treat ATTR amyloidosis is to reduce the amount of TTR produced by the liver using drugs that directly target the TTR …
Can we have it all? Repurposing target capture for repeat genomics. A commentary on: 'Aiming off the target: recycling target capture sequencing reads for investigating repetitive DNA'.
Heitkam T, Garcia S. Heitkam T, et al. Ann Bot. 2021 Nov 9;128(7):iii-v. doi: 10.1093/aob/mcab080. Ann Bot. 2021. PMID: 34289009 Free PMC article.
This article comments on: Lucas Costa, Andre Marques, Chris Buddenhagen, William Wayt Thomas, Bruno Huettel, Veit Schubert, Steven Dodsworth, Andreas Houben, Gustavo Souza and Andrea Pedrosa-Harand, Aiming off the target: recycling target capture sequencing r …
This article comments on: Lucas Costa, Andre Marques, Chris Buddenhagen, William Wayt Thomas, Bruno Huettel, Veit Schubert, Steven Dodsworth …
Pathogenesis of Osteoporosis.
Al Saedi A, Stupka N, Duque G. Al Saedi A, et al. Handb Exp Pharmacol. 2020;262:353-367. doi: 10.1007/164_2020_358. Handb Exp Pharmacol. 2020. PMID: 32297003
With an aging population, the prevalence of osteoporosis is on the rise. Although advances in the field have made progress in targeting the mechanisms of the disease, the efficacy of current treatments remains limited and is complicated by unexpected side effects. ...
With an aging population, the prevalence of osteoporosis is on the rise. Although advances in the field have made progress in targeting …
Giardia telomeres and telomerase.
Lagunas-Rangel FA. Lagunas-Rangel FA. Parasitol Res. 2024 Apr 8;123(4):179. doi: 10.1007/s00436-024-08200-6. Parasitol Res. 2024. PMID: 38584235 Free PMC article. Review.
Despite the availability of treatments for this parasitic infection, therapeutic failures are alarmingly frequent. Thus, there is a clear need to identify new therapeutic targets. Giardia telomeres were previously identified, but our understanding of these structures and t …
Despite the availability of treatments for this parasitic infection, therapeutic failures are alarmingly frequent. Thus, there is a clear ne …
Future Challenges of Multimodality Imaging.
López-Mora DA, Lagos LA, Estorch M, Carrio I. López-Mora DA, et al. Recent Results Cancer Res. 2020;216:905-918. doi: 10.1007/978-3-030-42618-7_30. Recent Results Cancer Res. 2020. PMID: 32594412 Review.
These developments are paralleled by advances in the field of biomolecules and particles that will provide new agents useful for more than one imaging modality and will facilitate the study of the same target by different imaging devices. Digital PET/CT may emerge as a pow …
These developments are paralleled by advances in the field of biomolecules and particles that will provide new agents useful for more than o …
Outcomes of target vessel endoleaks after fenestrated-branched endovascular aortic repair.
Kärkkäinen JM, Tenorio ER, Jain A, Mendes BC, Macedo TA, Pather K, Gloviczki P, Oderich GS. Kärkkäinen JM, et al. J Vasc Surg. 2020 Aug;72(2):445-455. doi: 10.1016/j.jvs.2019.09.055. Epub 2020 Jan 21. J Vasc Surg. 2020. PMID: 31980247 Free article.
Thirty-three patients (9%) had primary target vessel endoleaks in 41 target vessels (3%). Eight patients (2%) developed 11 secondary target vessel endoleaks. ...However, branch endoleaks resolved more often spontaneously (11/14 [79%]) compared with fenestrati …
Thirty-three patients (9%) had primary target vessel endoleaks in 41 target vessels (3%). Eight patients (2%) developed 11 sec …
271 results