Synthesis of the key precursor of Hirsutellide A

Yanjie Xu; Xuemin Duan; Meiling Li; Liqin Jiang; Guangle Zhao; Yi Meng; Ligong Chen

doi:10.3390/10010259

Synthesis of the key precursor of Hirsutellide A

Molecules. 2005 Jan 31;10(1):259-64. doi: 10.3390/10010259.

Authors

Yanjie Xu¹, Xuemin Duan, Meiling Li, Liqin Jiang, Guangle Zhao, Yi Meng, Ligong Chen

Affiliation

¹ College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin, 300072, PR China.

Abstract

Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.

MeSH terms

Models, Biological
Peptides, Cyclic / chemical synthesis
Peptides, Cyclic / chemistry*
Prodrugs / chemical synthesis
Protein Precursors / chemical synthesis*

Substances

Peptides, Cyclic
Prodrugs
Protein Precursors
hirsutellide A