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Canine NAPEPLD-associated models of human myelin disorders.
Minor KM, Letko A, Becker D, Drögemüller M, Mandigers PJJ, Bellekom SR, Leegwater PAJ, Stassen QEM, Putschbach K, Fischer A, Flegel T, Matiasek K, Ekenstedt KJ, Furrow E, Patterson EE, Platt SR, Kelly PA, Cassidy JP, Shelton GD, Lucot K, Bannasch DL, Martineau H, Muir CF, Priestnall SL, Henke D, Oevermann A, Jagannathan V, Mickelson JR, Drögemüller C. Minor KM, et al. Sci Rep. 2018 Apr 11;8(1):5818. doi: 10.1038/s41598-018-23938-7. Sci Rep. 2018. PMID: 29643404 Free PMC article.
Haplotype analysis of SNP array genotypes revealed that the frameshift variant was present in diverse haplotypes in Rottweilers, and also in Great Danes, indicating an old origin of this second NAPEPLD variant. ...
Haplotype analysis of SNP array genotypes revealed that the frameshift variant was present in diverse haplotypes in Rottweilers, and also in …
Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes.
Wiersma AC, Leegwater PA, van Oost BA, Ollier WE, Dukes-McEwan J. Wiersma AC, et al. BMC Vet Res. 2007 Oct 19;3:28. doi: 10.1186/1746-6148-3-28. BMC Vet Res. 2007. PMID: 17949487 Free PMC article.
Dilated cardiomyopathy has been observed in several, mostly large and giant, dog breeds, such as the Dobermann and the Great Dane. A number of genes have been identified, which are associated with dilated cardiomyopathy in the human, mouse and hamster. ...
Dilated cardiomyopathy has been observed in several, mostly large and giant, dog breeds, such as the Dobermann and the Great Dane. A …
Evaluation of the phospholamban gene in purebred large-breed dogs with dilated cardiomyopathy.
Stabej P, Leegwater PA, Stokhof AA, Domanjko-Petric A, van Oost BA. Stabej P, et al. Am J Vet Res. 2005 Mar;66(3):432-6. doi: 10.2460/ajvr.2005.66.432. Am J Vet Res. 2005. PMID: 15822587 Free article.
ANIMALS: 6 dogs with DCM, including 2 Doberman Pinschers, 2 Newfoundlands, and 2 Great Danes. PROCEDURE: All dogs had clinical signs of congestive heart failure, and a diagnosis of DCM was made on the basis of echocardiographic findings. ...CONCLUSIONS AND CLINICAL RELEVAN …
ANIMALS: 6 dogs with DCM, including 2 Doberman Pinschers, 2 Newfoundlands, and 2 Great Danes. PROCEDURE: All dogs had clinical signs …