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CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling.
Henry KL, Kellner D, Bajrami B, Anderson JE, Beyna M, Bhisetti G, Cameron T, Capacci AG, Bertolotti-Ciarlet A, Feng J, Gao B, Hopkins B, Jenkins T, Li K, May-Dracka T, Murugan P, Wei R, Zeng W, Allaire N, Buckler A, Loh C, Juhasz P, Lucas B, Ennis KA, Vollman E, Cahir-McFarland E, Hett EC, Ols ML. Henry KL, et al. Among authors: bhisetti g. Sci Signal. 2018 Jul 31;11(541):eaam8216. doi: 10.1126/scisignal.aam8216. Sci Signal. 2018. PMID: 30065029
Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors.
Bonafoux D, Nanthakumar S, Bandarage UK, Memmott C, Lowe D, Aronov AM, Bhisetti GR, Bonanno KC, Coll J, Leeman J, Lepre CA, Lu F, Perola E, Rijnbrand R, Taylor WP, Wilson D, Zhou Y, Zwahlen J, Ter Haar E. Bonafoux D, et al. Among authors: bhisetti gr. J Med Chem. 2016 Aug 11;59(15):7138-51. doi: 10.1021/acs.jmedchem.6b00486. Epub 2016 Jul 20. J Med Chem. 2016. PMID: 27385654
Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension.
Marcotte D, Rushe M, M Arduini R, Lukacs C, Atkins K, Sun X, Little K, Cullivan M, Paramasivam M, Patterson TA, Hesson T, D McKee T, May-Dracka TL, Xin Z, Bertolotti-Ciarlet A, Bhisetti GR, Lyssikatos JP, Silvian LF. Marcotte D, et al. Among authors: bhisetti gr. Protein Sci. 2017 Feb;26(2):152-162. doi: 10.1002/pro.3062. Epub 2016 Oct 21. Protein Sci. 2017. PMID: 27727493 Free PMC article.
Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity.
May-Dracka TL, Arduini R, Bertolotti-Ciarlet A, Bhisetti G, Brickelmaier M, Cahir-McFarland E, Enyedy I, Fontenot JD, Hesson T, Little K, Lyssikatos J, Marcotte D, McKee T, Murugan P, Patterson T, Peng H, Rushe M, Silvian L, Spilker K, Wu P, Xin Z, Burkly LC. May-Dracka TL, et al. Among authors: bhisetti g. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1964-1971. doi: 10.1016/j.bmcl.2018.03.032. Epub 2018 Mar 26. Bioorg Med Chem Lett. 2018. PMID: 29636220