Self-assembled monolayers of silver nanoparticles firmly grafted on glass surfaces: low Ag+ release for an efficient antibacterial activity

J Colloid Interface Sci. 2010 Oct 1;350(1):110-6. doi: 10.1016/j.jcis.2010.06.019. Epub 2010 Jun 15.

Abstract

A two-step, easy synthetic strategy in solution has been optimized to prepare authentic monolayers of silver nanoparticles (NP) on MPTS-modified glass surfaces, that were investigated by AFM imaging and by quantitative silver determination techniques. NP in the monolayers remain firmly grafted (i.e. not released) when the surfaces are exposed to air, water or in the physiological conditions mimicked by phosphate saline buffer, as UV-Vis spectroscopy and AFM studies demonstrate. About 15% silver release as Ag(+) ions has been found after 15days when the surfaces are exposed to water. The released silver cations are responsible of an efficient local microbicidal activity against Escherichia coli and Staphylococcus aureus bacterial strains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Drug Stability
  • Glass / chemistry*
  • Microscopy, Atomic Force
  • Models, Biological
  • Nanoparticles / chemistry*
  • Silver / chemistry*
  • Silver / pharmacokinetics
  • Silver / pharmacology
  • Surface Properties

Substances

  • Anti-Bacterial Agents
  • Silver