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Page 1
Showing results for gi no kit
Search for Gi No Kim instead (1 results)
Gastrointestinal Stromal Tumors.
von Mehren M, Joensuu H. von Mehren M, et al. J Clin Oncol. 2018 Jan 10;36(2):136-143. doi: 10.1200/JCO.2017.74.9705. Epub 2017 Dec 8. J Clin Oncol. 2018. PMID: 29220298 Free PMC article. Review.
GI stromal tumors (GISTs) are neoplasms with a varying malignancy potential ranging from virtually indolent tumors to rapidly progressing cancers. GISTs occur throughout the intestinal tract, and most harbor an activating mutation in either KIT or platelet-derived g …
GI stromal tumors (GISTs) are neoplasms with a varying malignancy potential ranging from virtually indolent tumors to rapidly progres …
Gastrointestinal stromal tumors: pathology and prognosis at different sites.
Miettinen M, Lasota J. Miettinen M, et al. Semin Diagn Pathol. 2006 May;23(2):70-83. doi: 10.1053/j.semdp.2006.09.001. Semin Diagn Pathol. 2006. PMID: 17193820 Review.
Gastrointestinal (GI) stromal tumors (GISTs) are the most common mesenchymal tumors specific to the GI tract, generally defined as KIT (CD117)-positive tumors with a characteristic set of histologic features. ...Intestinal GISTs are a histologically more homo …
Gastrointestinal (GI) stromal tumors (GISTs) are the most common mesenchymal tumors specific to the GI tract, generally define …
Biologics for the Use in Chronic Spontaneous Urticaria: When and Which.
Maurer M, Khan DA, Elieh Ali Komi D, Kaplan AP. Maurer M, et al. J Allergy Clin Immunol Pract. 2021 Mar;9(3):1067-1078. doi: 10.1016/j.jaip.2020.11.043. J Allergy Clin Immunol Pract. 2021. PMID: 33685605 Review.
Finally, we discuss targets for novel biologics and where we stand with their clinical development. These include IgE/ligelizumab, IgE/GI-310, thymic stromal lymphopoietin/tezepelumab, C5a receptor/avdoralimab, sialic acid-binding Ig-like lectin 8/lirentelimab, CD200R/LY34 …
Finally, we discuss targets for novel biologics and where we stand with their clinical development. These include IgE/ligelizumab, IgE/GI …
Avapritinib Versus Regorafenib in Locally Advanced Unresectable or Metastatic GI Stromal Tumor: A Randomized, Open-Label Phase III Study.
Kang YK, George S, Jones RL, Rutkowski P, Shen L, Mir O, Patel S, Zhou Y, von Mehren M, Hohenberger P, Villalobos V, Brahmi M, Tap WD, Trent J, Pantaleo MA, Schöffski P, He K, Hew P, Newberry K, Roche M, Heinrich MC, Bauer S. Kang YK, et al. J Clin Oncol. 2021 Oct 1;39(28):3128-3139. doi: 10.1200/JCO.21.00217. Epub 2021 Aug 3. J Clin Oncol. 2021. PMID: 34343033 Free PMC article. Clinical Trial.
PURPOSE: Primary or secondary mutations in KIT or platelet-derived growth factor receptor alpha (PDGFRA) underlie tyrosine kinase inhibitor resistance in most GI stromal tumors (GISTs). Avapritinib selectively and potently inhibits KIT- and PDGFRA-mutant kina …
PURPOSE: Primary or secondary mutations in KIT or platelet-derived growth factor receptor alpha (PDGFRA) underlie tyrosine kinase inh …
KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape.
Mühlenberg T, Falkenhorst J, Schulz T, Fletcher BS, Teuber A, Krzeciesa D, Klooster I, Lundberg M, Wilson L, Lategahn J, von Mehren M, Grunewald S, Tüns AI, Wardelmann E, Sicklick JK, Brahmi M, Serrano C, Schildhaus HU, Sievers S, Treckmann J, Heinrich MC, Raut CP, Ou WB, Marino-Enriquez A, George S, Rauh D, Fletcher JA, Bauer S. Mühlenberg T, et al. J Clin Oncol. 2024 Apr 20;42(12):1439-1449. doi: 10.1200/JCO.23.01197. Epub 2024 Feb 26. J Clin Oncol. 2024. PMID: 38408285
PURPOSE: Imatinib resistance in GI stromal tumors (GISTs) is primarily caused by secondary KIT mutations, and clonal heterogeneity of these secondary mutations represents a major treatment obstacle. ...KIT-inhibitor combinations may suppress resistance becaus …
PURPOSE: Imatinib resistance in GI stromal tumors (GISTs) is primarily caused by secondary KIT mutations, and clonal heterogen …
SCF/c-Kit-activated signaling and angiogenesis require Galphai1 and Galphai3.
Shan HJ, Jiang K, Zhao MZ, Deng WJ, Cao WH, Li JJ, Li KR, She C, Luo WF, Yao J, Zhou XZ, Zhang D, Cao C. Shan HJ, et al. Int J Biol Sci. 2023 Mar 27;19(6):1910-1924. doi: 10.7150/ijbs.82855. eCollection 2023. Int J Biol Sci. 2023. PMID: 37063428 Free PMC article.
In MEFs and HUVECs, Galphai1/3 was associated with SCF-activated c-Kit, promoting c-Kit endocytosis, and binding of key adaptor proteins, subsequently transducing downstream signaling. ...Taken together, Galphai1/3 mediate SCF/c-Kit-activated signaling and an …
In MEFs and HUVECs, Galphai1/3 was associated with SCF-activated c-Kit, promoting c-Kit endocytosis, and binding of key adapto …
Gastrointestinal stromal tumours.
Miettinen M, Sarlomo-Rikala M, Lasota J. Miettinen M, et al. Ann Chir Gynaecol. 1998;87(4):278-81. Ann Chir Gynaecol. 1998. PMID: 9891765 Review.
Genetically GISTs commonly show DNA losses in the long arm of chromosome 14, and c-kit gene mutations occur at least in some cases. c-kit is also expressed in the interstitial cells of Cajal, the gastrointestinal pacemaker cells, and relationship of GISTs to these c …
Genetically GISTs commonly show DNA losses in the long arm of chromosome 14, and c-kit gene mutations occur at least in some cases. c …
Gastrointestinal stromal tumor.
Stamatakos M, Douzinas E, Stefanaki C, Safioleas P, Polyzou E, Levidou G, Safioleas M. Stamatakos M, et al. World J Surg Oncol. 2009 Aug 1;7:61. doi: 10.1186/1477-7819-7-61. World J Surg Oncol. 2009. PMID: 19646278 Free PMC article. Review.
BACKGROUND: GISTs are a subset of mesenchymal tumors and represent the most common mesenchymal neoplasms of GI tract. However, GIST is a recently recognized tumor entity and the literature on these stromal tumors has rapidly expanded. ...An extensive literature search for …
BACKGROUND: GISTs are a subset of mesenchymal tumors and represent the most common mesenchymal neoplasms of GI tract. However, GIST i …
KIT and PDGFRA mutations and the risk of GI stromal tumor recurrence.
Joensuu H, Rutkowski P, Nishida T, Steigen SE, Brabec P, Plank L, Nilsson B, Braconi C, Bordoni A, Magnusson MK, Sufliarsky J, Federico M, Jonasson JG, Hostein I, Bringuier PP, Emile JF. Joensuu H, et al. J Clin Oncol. 2015 Feb 20;33(6):634-42. doi: 10.1200/JCO.2014.57.4970. Epub 2015 Jan 20. J Clin Oncol. 2015. PMID: 25605837
PURPOSE: Mutated KIT and platelet-derived growth factor alpha gene (PDGFRA) drive GI stromal tumor (GIST) oncogenesis, but the clinical significance of their single mutations is known incompletely. ...RESULTS: We identified 301 different single mutations in KIT …
PURPOSE: Mutated KIT and platelet-derived growth factor alpha gene (PDGFRA) drive GI stromal tumor (GIST) oncogenesis, but the …
Latest advances in adult gastrointestinal stromal tumors.
Florou V, Wilky BA, Trent JC. Florou V, et al. Future Oncol. 2017 Oct;13(24):2183-2193. doi: 10.2217/fon-2017-0245. Epub 2017 Oct 6. Future Oncol. 2017. PMID: 28984483 Review.
Gastrointestinal stromal tumors (GISTs) are the most common GI tract mesenchymal tumors. GIST patients are optimally managed by a precision medicine approach. ...New mechanisms to bypass this resistance by inhibiting KIT downstream pathways and by targeting multiple …
Gastrointestinal stromal tumors (GISTs) are the most common GI tract mesenchymal tumors. GIST patients are optimally managed by a pre …
591 results