Investigation of 123I production using electron accelerator

Albert Avetisyan; Robert Avagyan; Ruben Dallakyan; Gohar Avdalyan; Nikolay Dobrovolsky; Vasak Gavalyan; Ivetta Kerobyan; Gevorg Harutyunyan

doi:10.1016/j.nucmedbio.2016.12.007

Investigation of ¹²³I production using electron accelerator

Nucl Med Biol. 2017 Apr:47:44-47. doi: 10.1016/j.nucmedbio.2016.12.007. Epub 2016 Dec 22.

Authors

Albert Avetisyan¹, Robert Avagyan², Ruben Dallakyan³, Gohar Avdalyan⁴, Nikolay Dobrovolsky⁵, Vasak Gavalyan⁶, Ivetta Kerobyan⁷, Gevorg Harutyunyan⁸

Affiliations

¹ A. I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation, 0036, Yerevan, Armenia. Electronic address: albert@mail.yerphi.am.
² A. I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation, 0036, Yerevan, Armenia. Electronic address: ravakian@mail.yerphi.am.
³ A. I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation, 0036, Yerevan, Armenia. Electronic address: rubendallakyan@mail.yerphi.am.
⁴ A. I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation, 0036, Yerevan, Armenia. Electronic address: gohar@mail.yerphi.am.
⁵ A. I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation, 0036, Yerevan, Armenia. Electronic address: mikola@mail.yerphi.am.
⁶ A. I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation, 0036, Yerevan, Armenia. Electronic address: vasak@mail.yerphi.am.
⁷ A. I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation, 0036, Yerevan, Armenia. Electronic address: keropyan@mail.yerphi.am.
⁸ A. I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation, 0036, Yerevan, Armenia. Electronic address: gevharut@mail.yerphi.com.

PMID: 28110123
DOI: 10.1016/j.nucmedbio.2016.12.007

Abstract

The possibility of ¹²³I isotope production with the help of the high-intensity bremsstrahlung photons produced by the electron beam of the LUE50 linear electron accelerator at the A.I. Alikhanyan National Science Laboratory (Yerevan Physics Institute [YerPhI]) is considered. The production method has been established and shown to be successful. The ¹²⁴Xe(γ,n)¹²³Xe→¹²³I nuclear reaction has been investigated and the cross-section was calculated by nuclear codes TALYS 1.6 and EMPIRE 3.2. The optimum parameter of the thickness of the target was determined by GEANT4 code. For the normalized yield of ¹²³I, the value of 143Bq/(mg·μA·h) has been achieved.

Keywords: (123)I; Nuclear medicine; Photoproduction; Radioisotopes.

MeSH terms

Electrons*
Iodine Radioisotopes / chemistry*
Monte Carlo Method
Particle Accelerators*
Radiochemistry / instrumentation*

Substances

Iodine Radioisotopes