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1958 5
1959 3
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9,191 results

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The following term was not found in PubMed: Geunyong
Page 1
Did you mean eunyoung bak (1 results)?
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation.
Cosentino K, Hertlein V, Jenner A, Dellmann T, Gojkovic M, Peña-Blanco A, Dadsena S, Wajngarten N, Danial JSH, Thevathasan JV, Mund M, Ries J, Garcia-Saez AJ. Cosentino K, et al. Mol Cell. 2022 Mar 3;82(5):933-949.e9. doi: 10.1016/j.molcel.2022.01.008. Epub 2022 Feb 3. Mol Cell. 2022. PMID: 35120587 Free PMC article.
However, the mechanism by which they assemble the apoptotic pore remains obscure. Here, we report that BAX and BAK present distinct oligomerization properties, with BAK organizing into smaller structures with faster kinetics than BAX. BAK recruits and acceler …
However, the mechanism by which they assemble the apoptotic pore remains obscure. Here, we report that BAX and BAK present distinct o …
Applications of bakuchiol in dermatology: Systematic review of the literature.
Puyana C, Chandan N, Tsoukas M. Puyana C, et al. J Cosmet Dermatol. 2022 Dec;21(12):6636-6643. doi: 10.1111/jocd.15420. Epub 2022 Oct 31. J Cosmet Dermatol. 2022. PMID: 36176207 Review.
The trend for "clean" skincare products and search for anti-aging retinoid alternatives have poised BAK as a "must-have" ingredient in skincare. AIMS: Our aim was to review the data for the applications of BAK in dermatology. ...While having no structural resemblanc …
The trend for "clean" skincare products and search for anti-aging retinoid alternatives have poised BAK as a "must-have" ingredient i …
Eltrombopag directly activates BAK and induces apoptosis.
Chen M, Hu L, Bao X, Ye K, Li Y, Zhang Z, Kaufmann SH, Xiao J, Dai H. Chen M, et al. Cell Death Dis. 2023 Jul 1;14(7):394. doi: 10.1038/s41419-023-05918-6. Cell Death Dis. 2023. PMID: 37393297 Free PMC article.
Small molecule direct BAK activators can potentially be used for the development of anti-cancer drugs or as tools to study BAK activation. ...Thus, our data suggest that Eltro directly induces BAK activation and BAK-dependent apoptosis, providing a sta …
Small molecule direct BAK activators can potentially be used for the development of anti-cancer drugs or as tools to study BAK …
BAK contributes critically to necrosis and infarct generation during reperfused myocardial infarction.
Qin D, Jia XF, Hanna A, Lee J, Pekson R, Elrod JW, Calvert JW, Frangogiannis NG, Kitsis RN. Qin D, et al. J Mol Cell Cardiol. 2023 Nov;184:1-12. doi: 10.1016/j.yjmcc.2023.09.004. Epub 2023 Sep 12. J Mol Cell Cardiol. 2023. PMID: 37709008
Protection from necrosis was also observed in BAK-deficient isolated cardiomyocytes suggesting that the cardioprotection from BAK loss in vivo is at least partially cardiomyocyte-autonomous. Interestingly, heterozygous Bak deletion, in which the heart still r …
Protection from necrosis was also observed in BAK-deficient isolated cardiomyocytes suggesting that the cardioprotection from BAK …
Bax and Bak Pores: Are We Closing the Circle?
Cosentino K, García-Sáez AJ. Cosentino K, et al. Trends Cell Biol. 2017 Apr;27(4):266-275. doi: 10.1016/j.tcb.2016.11.004. Epub 2016 Dec 5. Trends Cell Biol. 2017. PMID: 27932064 Free PMC article. Review.
Bax and its homolog Bak are key regulators of the mitochondrial pathway of apoptosis. ...The molecular mechanisms of Bax and Bak assembly and mitochondrial permeabilization have remained a longstanding question in the field. ...
Bax and its homolog Bak are key regulators of the mitochondrial pathway of apoptosis. ...The molecular mechanisms of Bax and Bak …
Preservatives in glaucoma medication.
Steven DW, Alaghband P, Lim KS. Steven DW, et al. Br J Ophthalmol. 2018 Nov;102(11):1497-1503. doi: 10.1136/bjophthalmol-2017-311544. Epub 2018 Jul 4. Br J Ophthalmol. 2018. PMID: 29973365 Free PMC article. Review.
An extensive body of literature explores BAK toxicity on ocular structures in animal and laboratory studies (in vitro and in vivo). ...Notwithstanding, those that have been published, have not demonstrated any clear benefits of the BAK-free formulations. Short durat …
An extensive body of literature explores BAK toxicity on ocular structures in animal and laboratory studies (in vitro and in vivo). . …
BCL-XL directly retrotranslocates the monomeric BAK.
Wang B, Mai Z, Du M, Wang L, Yang F, Ma Y, Wang X, Chen T. Wang B, et al. Cell Signal. 2019 Sep;61:1-9. doi: 10.1016/j.cellsig.2019.05.001. Epub 2019 May 3. Cell Signal. 2019. PMID: 31059787
This report aims to explore which form of mitochondrial monomeric and oligomerized BAK can be retrotranslocated by BCL-XL. Fluorescence imaging of living cells co-expressing CFP-BCL-XL and YFP-BAK showed that BCL-XL markedly inhibited mitochondrial BAK oligom …
This report aims to explore which form of mitochondrial monomeric and oligomerized BAK can be retrotranslocated by BCL-XL. Fluorescen …
Structural basis of BAK activation in mitochondrial apoptosis initiation.
Singh G, Guibao CD, Seetharaman J, Aggarwal A, Grace CR, McNamara DE, Vaithiyalingam S, Waddell MB, Moldoveanu T. Singh G, et al. Nat Commun. 2022 Jan 11;13(1):250. doi: 10.1038/s41467-021-27851-y. Nat Commun. 2022. PMID: 35017502 Free PMC article.
Here we investigate autoactivation and direct activation by BH3-only proteins, which cooperate to lower BAK threshold in membrane poration and apoptosis initiation. We define in trans BAK autoactivation as the asymmetric "BH3-in-groove" triggering of dormant BAK …
Here we investigate autoactivation and direct activation by BH3-only proteins, which cooperate to lower BAK threshold in membrane por …
BAK regulates catalase release from peroxisomes.
Fujiki Y, Miyata N, Mukai S, Okumoto K, Cheng EH. Fujiki Y, et al. Mol Cell Oncol. 2017 Mar 17;4(3):e1306610. doi: 10.1080/23723556.2017.1306610. eCollection 2017. Mol Cell Oncol. 2017. PMID: 28616584 Free PMC article.
Moreover, overexpression of BAK activators in wild-type cells permeabilizes peroxisomes in a BAK-dependent manner. Together, BAK most likely regulates peroxisomal membrane permeability....
Moreover, overexpression of BAK activators in wild-type cells permeabilizes peroxisomes in a BAK-dependent manner. Together, …
Bak interacts with AKT and is involved in TNFalpha/CHX-induced apoptosis.
Song J, Zhang F, Wang Y, Wang Y, Zhang J, Xiao Z, Fu X, Xu X, Zeng L. Song J, et al. Mol Cell Biochem. 2022 Mar;477(3):939-949. doi: 10.1007/s11010-021-04348-2. Epub 2022 Jan 30. Mol Cell Biochem. 2022. PMID: 35094193
Bak is important for TNFalpha/CHX-induced neuronal death, but the precise molecular mechanism remains unclear. ...This study for the first time clarified the association between the MAPK and AKT under the TNFalpha/CHX stimulation upon addition of different kinase inhibitor …
Bak is important for TNFalpha/CHX-induced neuronal death, but the precise molecular mechanism remains unclear. ...This study for the …
9,191 results