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Page 1
The adverse outcome pathway for skin sensitisation: Moving closer to replacing animal testing.
Altern Lab Anim. 2016 Oct;44(5):453-460. doi: 10.1177/026119291604400515.
Altern Lab Anim. 2016.
PMID: 27805828
Review.
Use of genotoxicity information in the development of integrated testing strategies (ITS) for skin sensitization.
Mekenyan O, Patlewicz G, Dimitrova G, Kuseva C, Todorov M, Stoeva S, Kotov S, Donner EM.
Mekenyan O, et al. Among authors: dimitrova g.
Chem Res Toxicol. 2010 Oct 18;23(10):1519-40. doi: 10.1021/tx100161j. Epub 2010 Sep 16.
Chem Res Toxicol. 2010.
PMID: 20845941
Review.
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TIMES-SS--a mechanistic evaluation of an external validation study using reaction chemistry principles.
Roberts DW, Patlewicz G, Dimitrov SD, Low LK, Aptula AO, Kern PS, Dimitrova GD, Comber MI, Phillips RD, Niemelä J, Madsen C, Wedebye EB, Bailey PT, Mekenyan OG.
Roberts DW, et al. Among authors: dimitrova gd.
Chem Res Toxicol. 2007 Sep;20(9):1321-30. doi: 10.1021/tx700169w. Epub 2007 Aug 23.
Chem Res Toxicol. 2007.
PMID: 17713962
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Skin sensitization: modeling based on skin metabolism simulation and formation of protein conjugates.
Dimitrov SD, Low LK, Patlewicz GY, Kern PS, Dimitrova GD, Comber MH, Phillips RD, Niemela J, Bailey PT, Mekenyan OG.
Dimitrov SD, et al. Among authors: dimitrova gd.
Int J Toxicol. 2005 Jul-Aug;24(4):189-204. doi: 10.1080/10915810591000631.
Int J Toxicol. 2005.
PMID: 16126613
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What determines skin sensitization potency-myths, maybes and realities. Part 1. The 500 molecular weight cut-off.
Roberts DW, Mekenyan OG, Dimitrov SD, Dimitrova GD.
Roberts DW, et al. Among authors: dimitrova gd.
Contact Dermatitis. 2013 Jan;68(1):32-41. doi: 10.1111/j.1600-0536.2012.02160.x. Epub 2012 Aug 25.
Contact Dermatitis. 2013.
PMID: 22924443
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A stepwise approach for defining the applicability domain of SAR and QSAR models.
Dimitrov S, Dimitrova G, Pavlov T, Dimitrova N, Patlewicz G, Niemela J, Mekenyan O.
Dimitrov S, et al. Among authors: dimitrova g.
J Chem Inf Model. 2005 Jul-Aug;45(4):839-49. doi: 10.1021/ci0500381.
J Chem Inf Model. 2005.
PMID: 16045276
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TIMES-SS--a promising tool for the assessment of skin sensitization hazard. A characterization with respect to the OECD validation principles for (Q)SARs and an external evaluation for predictivity.
Patlewicz G, Dimitrov SD, Low LK, Kern PS, Dimitrova GD, Comber MI, Aptula AO, Phillips RD, Niemelä J, Madsen C, Wedebye EB, Roberts DW, Bailey PT, Mekenyan OG.
Patlewicz G, et al. Among authors: dimitrova gd.
Regul Toxicol Pharmacol. 2007 Jul;48(2):225-39. doi: 10.1016/j.yrtph.2007.03.003. Epub 2007 Mar 25.
Regul Toxicol Pharmacol. 2007.
PMID: 17467128
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