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The antithrombotic effect of the aminoestrogen prolame (N-(3-hydroxy-1,3,5(10)-estratrien-17B-YL)-3-hydroxypropylamine) is linked to an increase in nitric oxide production by platelets and endothelial cells.
González G, Alvarado-Vasquez N, Fernández-G JM, Cruz-Robles D, Del Valle L, Pinzón E, Torres I, Rodriguez E, Zapata E, Gómez-Vidales V, Montaño LF, de la Peña A. González G, et al. Atherosclerosis. 2010 Jan;208(1):62-8. doi: 10.1016/j.atherosclerosis.2009.06.017. Epub 2009 Jun 18. Atherosclerosis. 2010. PMID: 19615684