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Did you mean gene s office editorial (96 results)?
Adoptive Cellular Therapy with Autologous Tumor-Infiltrating Lymphocytes and T-cell Receptor-Engineered T Cells Targeting Common p53 Neoantigens in Human Solid Tumors.
Kim SP, Vale NR, Zacharakis N, Krishna S, Yu Z, Gasmi B, Gartner JJ, Sindiri S, Malekzadeh P, Deniger DC, Lowery FJ, Parkhurst MR, Ngo LT, Ray S, Li YF, Hill V, Florentin M, Masi RV, Paria BC, Levin N, Bera A, Hedges EA, Choi A, Chatani PD, Parikh AY, Levi S, Seitter S, Lu YC, Zheng Z, Prickett TD, Jia L, Hernandez JM, Hoang CD, Robbins PF, Goff SL, Sherry RM, Yang JC, Rosenberg SA. Kim SP, et al. Cancer Immunol Res. 2022 Aug 3;10(8):932-946. doi: 10.1158/2326-6066.CIR-22-0040. Cancer Immunol Res. 2022. PMID: 35749374 Free PMC article.
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease.
Baloni P, Arnold M, Buitrago L, Nho K, Moreno H, Huynh K, Brauner B, Louie G, Kueider-Paisley A, Suhre K, Saykin AJ, Ekroos K, Meikle PJ, Hood L, Price ND; Alzheimer’s Disease Metabolomics Consortium; Doraiswamy PM, Funk CC, Hernández AI, Kastenmüller G, Baillie R, Han X, Kaddurah-Daouk R. Baloni P, et al. Commun Biol. 2022 Oct 8;5(1):1074. doi: 10.1038/s42003-022-04011-6. Commun Biol. 2022. PMID: 36209301 Free PMC article.
Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in lipid metabolism that are associated with Alzheimer's disease. ...Our multi-omics approach is based on (a) 2114 human post-mortem brain transcriptomics to identify …
Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in lipid metabolism that ar …
Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study.
Fang S, Yarmolinsky J, Gill D, Bull CJ, Perks CM; PRACTICAL Consortium; Davey Smith G, Gaunt TR, Richardson TG. Fang S, et al. PLoS Med. 2023 Jan 3;20(1):e1003988. doi: 10.1371/journal.pmed.1003988. eCollection 2023 Jan. PLoS Med. 2023. PMID: 36595504 Free PMC article.

METHODS AND FINDINGS: Single-nucleotide polymorphisms (SNPs) associated with LDL-c (P < 5 10-8) from the Global Lipids Genetics Consortium genome-wide association study (GWAS) (N = 1,320,016) and located in and around the HMGCR, NPC1L1, and PCSK9 genes were used to prox

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METHODS AND FINDINGS: Single-nucleotide polymorphisms (SNPs) associated with LDL-c (P < 5 10-8) from the Global Lipids Genetics Consortiu

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Genetics of hypogonadotropic hypogonadism.
Millar AC, Faghfoury H, Bieniek JM. Millar AC, et al. Transl Androl Urol. 2021 Mar;10(3):1401-1409. doi: 10.21037/tau.2020.03.33. Transl Androl Urol. 2021. PMID: 33850776 Free PMC article. Review.
Genetic testing techniques have expanded our knowledge of the underlying mechanisms contributing to CHH including over 30 genes to date implicated in the development of CHH. In some cases, non-reproductive signs or symptoms can give clues as to the putative genetic etiolog …
Genetic testing techniques have expanded our knowledge of the underlying mechanisms contributing to CHH including over 30 genes to da …
Pathology of thymoma-where are we today?
Soomro IN. Soomro IN. J Thorac Dis. 2020 Dec;12(12):7545-7552. doi: 10.21037/jtd-2019-thym-04. J Thorac Dis. 2020. PMID: 33447445 Free PMC article. Review.
Mutational analytical tests include EGFR, RAS, BRAF, RET, AKT1, PIK3CA and T53 genes. If adequate sample is available (upto100 cells), PD-L1 testing should be considered for immunotherapy in recurrent/ advanced thymomas and thymic carcinomas. ...
Mutational analytical tests include EGFR, RAS, BRAF, RET, AKT1, PIK3CA and T53 genes. If adequate sample is available (upto100 cells) …
Genomic alterations in thymoma-molecular pathogenesis?
Oberndorfer F, Müllauer L. Oberndorfer F, et al. J Thorac Dis. 2020 Dec;12(12):7536-7544. doi: 10.21037/jtd.2019.12.52. J Thorac Dis. 2020. PMID: 33447444 Free PMC article. Review.
Thymomas exhibit a low mutational burden and a few recurrently mutated genes. The most frequent missense mutation p.(Leu404His) affects the general transcription factor IIi (GTF2I) and is specific for thymic epithelial tumors (TETs). ...TCs, however, display a higher mutat …
Thymomas exhibit a low mutational burden and a few recurrently mutated genes. The most frequent missense mutation p.(Leu404His) affec …
Epigenetics in prostate cancer: clinical implications.
Conteduca V, Hess J, Yamada Y, Ku SY, Beltran H. Conteduca V, et al. Transl Androl Urol. 2021 Jul;10(7):3104-3116. doi: 10.21037/tau-20-1339. Transl Androl Urol. 2021. PMID: 34430414 Free PMC article. Review.
Epigenetic modifications are responsible for silencing tumor-suppressor genes, activating oncogenic drivers, and driving therapy resistance and thus have emerged as promising targets for antineoplastic therapy in prostate cancer. ...
Epigenetic modifications are responsible for silencing tumor-suppressor genes, activating oncogenic drivers, and driving therapy resi …
Ovarian cancer risk assessment in the era of next-generation sequencing.
Bonadio RC, Crespo JR, Estevez-Diz MDP. Bonadio RC, et al. Ann Transl Med. 2020 Dec;8(24):1704. doi: 10.21037/atm-20-1582. Ann Transl Med. 2020. PMID: 33490216 Free PMC article. Review.
However, alterations in other genes, such as BRIP1, RAD51C, RAD51D, and mismatch repair genes, also enhance ovarian cancer risk. Other genes may also participate in ovarian carcinogenesis, but their role as ovarian cancer susceptibility genes still nee …
However, alterations in other genes, such as BRIP1, RAD51C, RAD51D, and mismatch repair genes, also enhance ovarian cancer ris …
Decoding psychosis: from national genome project to national brain project.
Sun L, Xu M, Shi Y, Xu Y, Chen J, He L. Sun L, et al. Gen Psychiatr. 2022 Sep 22;35(4):e100889. doi: 10.1136/gpsych-2022-100889. eCollection 2022. Gen Psychiatr. 2022. PMID: 36248024 Free PMC article.
However, relatively recent biotechnological breakthroughs, such as DNA technology and neuroimaging, have empowered scientists to explore the more fundamental aspects of psychosis. From searching for psychosis-causing genes to imaging the depths of the brain, scientists wor …
However, relatively recent biotechnological breakthroughs, such as DNA technology and neuroimaging, have empowered scientists to explore the …
Revisiting hemochromatosis: genetic vs. phenotypic manifestations.
Anderson GJ, Bardou-Jacquet E. Anderson GJ, et al. Ann Transl Med. 2021 Apr;9(8):731. doi: 10.21037/atm-20-5512. Ann Transl Med. 2021. PMID: 33987429 Free PMC article. Review.
Other forms of blood loss, immune system influences, the amount of bioavailable iron in the diet and lifestyle factors such as high alcohol intake can also contribute to iron loading and disease expression. Polymorphisms in a range of genes have been linked to variations i …
Other forms of blood loss, immune system influences, the amount of bioavailable iron in the diet and lifestyle factors such as high alcohol …
126 results