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Page 1
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV Jr. Boland S, et al. Among authors: aggarwal g. Nat Commun. 2022 Oct 7;13(1):5924. doi: 10.1038/s41467-022-33500-9. Nat Commun. 2022. PMID: 36207292 Free PMC article.
Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation.
Aggarwal G, Banerjee S, Jones SA, Benchaar Y, Bélanger J, Sévigny M, Smith DM, Niehoff ML, Pavlack M, de Vera IMS, Petkau TL, Leavitt BR, Ling K, Jafar-Nejad P, Rigo F, Morley JE, Farr SA, Dutchak PA, Sephton CF, Nguyen AD. Aggarwal G, et al. J Biol Chem. 2023 Dec;299(12):105475. doi: 10.1016/j.jbc.2023.105475. Epub 2023 Nov 18. J Biol Chem. 2023. PMID: 37981208 Free PMC article.
32 results