Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants

Molecules. 2015 May 14;20(5):8654-65. doi: 10.3390/molecules20058654.

Abstract

A palladium mediated synthesis of a common synthon for the syntheses of antioxidant analogues of naturally occurring salvianolic acids is presented. The synthetic route may be used to obtain analogues with a balanced lipophilicity/hydrophilicity which may result in potentially interesting LDL antioxidants for the prevention of cardiovascular diseases.

Keywords: antioxidant; benzofuran; palladium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemical synthesis
  • Alkenes / chemistry*
  • Alkenes / metabolism
  • Antioxidants / chemical synthesis*
  • Antioxidants / chemistry
  • Benzofurans / chemical synthesis*
  • Benzofurans / chemistry
  • Benzofurans / metabolism
  • Lipoproteins, LDL / metabolism*
  • Medicine, Chinese Traditional
  • Oxidative Stress
  • Palladium / chemistry
  • Polyphenols / chemical synthesis
  • Polyphenols / chemistry*
  • Polyphenols / metabolism

Substances

  • Alkenes
  • Antioxidants
  • Benzofurans
  • Lipoproteins, LDL
  • Polyphenols
  • tournefolal
  • Palladium
  • salvianolic acid C