Abstract
A palladium mediated synthesis of a common synthon for the syntheses of antioxidant analogues of naturally occurring salvianolic acids is presented. The synthetic route may be used to obtain analogues with a balanced lipophilicity/hydrophilicity which may result in potentially interesting LDL antioxidants for the prevention of cardiovascular diseases.
Keywords:
antioxidant; benzofuran; palladium.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemical synthesis
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Alkenes / chemistry*
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Alkenes / metabolism
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Antioxidants / chemical synthesis*
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Antioxidants / chemistry
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Benzofurans / chemical synthesis*
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Benzofurans / chemistry
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Benzofurans / metabolism
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Lipoproteins, LDL / metabolism*
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Medicine, Chinese Traditional
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Oxidative Stress
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Palladium / chemistry
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Polyphenols / chemical synthesis
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Polyphenols / chemistry*
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Polyphenols / metabolism
Substances
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Alkenes
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Antioxidants
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Benzofurans
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Lipoproteins, LDL
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Polyphenols
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tournefolal
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Palladium
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salvianolic acid C