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Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition.
Silva G, Marins M, Chaichanasak N, Yoon Y, Fachin AL, Pinhanelli VC, Regasini LO, Dos Santos MB, Ayusso GM, Marques BC, Wu WW, Phue JN, Shen RF, Baek SJ. Silva G, et al. Among authors: ayusso gm. PLoS One. 2018 Aug 17;13(8):e0202263. doi: 10.1371/journal.pone.0202263. eCollection 2018. PLoS One. 2018. PMID: 30118500 Free PMC article.
Chalcones and their B-aryl analogues as myeloperoxidase inhibitors: In silico, in vitro and ex vivo investigations.
Santos MBD, Carvalho Marques B, Miranda Ayusso G, Rocha Garcia MA, Chiquetto Paracatu L, Pauli I, Silva Bolzani V, Defini Andricopulo A, Farias Ximenes V, Zeraik ML, Regasini LO. Santos MBD, et al. Among authors: miranda ayusso g. Bioorg Chem. 2021 May;110:104773. doi: 10.1016/j.bioorg.2021.104773. Epub 2021 Mar 2. Bioorg Chem. 2021. PMID: 33744807
Activity of 3'-hydroxychalcone against Cryptococcus gattii and toxicity, and efficacy in alternative animal models.
Palanco AC, Lacorte Singulani J, Costa-Orlandi CB, Gullo FP, Strohmayer Lourencetti NM, Gomes PC, Ayusso GM, Dutra LA, Silva Bolzani VD, Regasini LO, Soares Mendes-Giannini MJ, Fusco-Almeida AM. Palanco AC, et al. Among authors: ayusso gm. Future Microbiol. 2017 Oct;12:1123-1134. doi: 10.2217/fmb-2017-0062. Epub 2017 Sep 6. Future Microbiol. 2017. PMID: 28876122
The Dimeric Peptide (KKYRYHLKPF)2K Shows Broad-Spectrum Antiviral Activity by Inhibiting Different Steps of Chikungunya and Zika Virus Infection.
Ayusso GM, Lima MLD, da Silva Sanches PR, Santos IA, Martins DOS, da Conceição PJP, Carvalho T, da Costa VG, Bittar C, Merits A, Santos-Filho NA, Cilli EM, Jardim ACG, de Freitas Calmon M, Rahal P. Ayusso GM, et al. Viruses. 2023 May 14;15(5):1168. doi: 10.3390/v15051168. Viruses. 2023. PMID: 37243254 Free PMC article.