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Year Number of Results
2002 3
2004 1
2006 1
2007 1
2008 2
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2010 5
2011 3
2012 1
2013 2
2014 5
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2017 4
2018 1
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2021 5
2022 8
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52 results

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Page 1
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
Dejmek M, Brazdova A, Otava T, Polidarova MP, Klíma M, Smola M, Vavrina Z, Buděšínský M, Dračínský M, Liboska R, Boura E, Birkuš G, Nencka R. Dejmek M, et al. Among authors: birkus g. Eur J Med Chem. 2023 Nov 5;259:115685. doi: 10.1016/j.ejmech.2023.115685. Epub 2023 Jul 26. Eur J Med Chem. 2023. PMID: 37567057 Free article.
5'-Phosphonate modified oligoadenylates as potent activators of human RNase L.
Lášek T, Petrová M, Košiová I, Šimák O, Buděšínský M, Kozák J, Snášel J, Vavřina Z, Birkuš G, Rosenberg I, Páv O. Lášek T, et al. Among authors: birkus g. Bioorg Med Chem. 2022 Feb 15;56:116632. doi: 10.1016/j.bmc.2022.116632. Epub 2022 Jan 19. Bioorg Med Chem. 2022. PMID: 35078032
Molecular Determinants of GS-9620-Dependent TLR7 Activation.
Rebbapragada I, Birkus G, Perry J, Xing W, Kwon H, Pflanz S. Rebbapragada I, et al. Among authors: birkus g. PLoS One. 2016 Jan 19;11(1):e0146835. doi: 10.1371/journal.pone.0146835. eCollection 2016. PLoS One. 2016. PMID: 26784926 Free PMC article.
Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors.
Šála M, Kögler M, Plačková P, Mejdrová I, Hřebabecký H, Procházková E, Strunin D, Lee G, Birkus G, Weber J, Mertlíková-Kaiserová H, Nencka R. Šála M, et al. Among authors: birkus g. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2706-12. doi: 10.1016/j.bmcl.2016.04.002. Epub 2016 Apr 5. Bioorg Med Chem Lett. 2016. PMID: 27090557 Free PMC article.
Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential.
Dejmek M, Šála M, Brazdova A, Vanekova L, Smola M, Klíma M, Břehová P, Buděšínský M, Dračínský M, Procházková E, Zavřel M, Šimák O, Páv O, Boura E, Birkuš G, Nencka R. Dejmek M, et al. Among authors: birkus g. Structure. 2022 Aug 4;30(8):1146-1156.e11. doi: 10.1016/j.str.2022.05.012. Epub 2022 Jun 10. Structure. 2022. PMID: 35690061 Free article.
Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists.
Vavřina Z, Perlíková P, Milisavljević N, Chevrier F, Smola M, Smith J, Dejmek M, Havlíček V, Buděšínský M, Liboska R, Vaneková L, Brynda J, Boura E, Řezáčová P, Hocek M, Birkuš G. Vavřina Z, et al. Among authors: birkus g. J Med Chem. 2022 Oct 27;65(20):14082-14103. doi: 10.1021/acs.jmedchem.2c01305. Epub 2022 Oct 6. J Med Chem. 2022. PMID: 36201304 Free PMC article.
52 results