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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 2
2000 6
2001 3
2002 2
2003 3
2004 2
2005 5
2006 2
2007 3
2008 4
2009 6
2010 3
2011 5
2012 5
2013 4
2014 1
2015 4
2016 5
2017 10
2018 14
2019 18
2020 13
2021 19
2022 27
2023 19
2024 11

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175 results

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Page 1
Structure, function and pharmacology of human itch GPCRs.
Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL. Cao C, et al. Nature. 2021 Dec;600(7887):170-175. doi: 10.1038/s41586-021-04126-6. Epub 2021 Nov 17. Nature. 2021. PMID: 34789874 Free PMC article.
Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-mediated hypersensitivity reactions(2-5). MRGPRX2 couples to both G(i) and G(q) in mast cells(6). Here we describe agonist-stabilized structures of MRGPRX2 c …
Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-mediated hypersensitivity react …
Molecular basis for selective activation of DREADD-based chemogenetics.
Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL. Zhang S, et al. Nature. 2022 Dec;612(7939):354-362. doi: 10.1038/s41586-022-05489-0. Epub 2022 Nov 30. Nature. 2022. PMID: 36450989
The muscarinic receptor-based DREADDs are the most widely used chemogenetic tools in neuroscience research. The G(q)-coupled DREADD (hM3Dq) is used to enhance neuronal activity, whereas the G(i/o)-coupled DREADD (hM4Di) is utilized to inhibit neuronal activity(5). . …
The muscarinic receptor-based DREADDs are the most widely used chemogenetic tools in neuroscience research. The G(q)-coupled D …
Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma.
Zhang Y, Chen L, Hu GQ, Zhang N, Zhu XD, Yang KY, Jin F, Shi M, Chen YP, Hu WH, Cheng ZB, Wang SY, Tian Y, Wang XC, Sun Y, Li JG, Li WF, Li YH, Tang LL, Mao YP, Zhou GQ, Sun R, Liu X, Guo R, Long GX, Liang SQ, Li L, Huang J, Long JH, Zang J, Liu QD, Zou L, Su QF, Zheng BM, Xiao Y, Guo Y, Han F, Mo HY, Lv JW, Du XJ, Xu C, Liu N, Li YQ, Chua MLK, Xie FY, Sun Y, Ma J. Zhang Y, et al. N Engl J Med. 2019 Sep 19;381(12):1124-1135. doi: 10.1056/NEJMoa1905287. Epub 2019 May 31. N Engl J Med. 2019. PMID: 31150573 Clinical Trial.
Evaluation of cell-free DNA approaches for multi-cancer early detection.
Jamshidi A, Liu MC, Klein EA, Venn O, Hubbell E, Beausang JF, Gross S, Melton C, Fields AP, Liu Q, Zhang N, Fung ET, Kurtzman KN, Amini H, Betts C, Civello D, Freese P, Calef R, Davydov K, Fayzullina S, Hou C, Jiang R, Jung B, Tang S, Demas V, Newman J, Sakarya O, Scott E, Shenoy A, Shojaee S, Steffen KK, Nicula V, Chien TC, Bagaria S, Hunkapiller N, Desai M, Dong Z, Richards DA, Yeatman TJ, Cohn AL, Thiel DD, Berry DA, Tummala MK, McIntyre K, Sekeres MA, Bryce A, Aravanis AM, Seiden MV, Swanton C. Jamshidi A, et al. Cancer Cell. 2022 Dec 12;40(12):1537-1549.e12. doi: 10.1016/j.ccell.2022.10.022. Epub 2022 Nov 17. Cancer Cell. 2022. PMID: 36400018 Free article.
Patient-Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy.
Mo S, Tang P, Luo W, Zhang L, Li Y, Hu X, Ma X, Chen Y, Bao Y, He X, Fu G, Xu X, Rao X, Li X, Guan R, Chen S, Deng Y, Lv T, Mu P, Zheng Q, Wang S, Liu F, Li Y, Sheng W, Huang D, Hu C, Gao J, Zhang Z, Cai S, Clevers H, Peng J, Hua G. Mo S, et al. Adv Sci (Weinh). 2022 Nov;9(31):e2204097. doi: 10.1002/advs.202204097. Epub 2022 Sep 4. Adv Sci (Weinh). 2022. PMID: 36058001 Free PMC article.
Recent achievements in developing selective G(q) inhibitors.
Zhang H, Nielsen AL, Strømgaard K. Zhang H, et al. Med Res Rev. 2020 Jan;40(1):135-157. doi: 10.1002/med.21598. Epub 2019 Jun 19. Med Res Rev. 2020. PMID: 31218731 Review.
The natural cyclic depsipeptides YM-254890 and FR900359 are two of the very few known selective inhibitors of the G(q) subfamily, and are used as unique pharmacological tools in the study of G (q) -mediated signaling. Moreover, a peptide-based G protei …
The natural cyclic depsipeptides YM-254890 and FR900359 are two of the very few known selective inhibitors of the G(q) subfami …
Non-invasive early detection of cancer four years before conventional diagnosis using a blood test.
Chen X, Gole J, Gore A, He Q, Lu M, Min J, Yuan Z, Yang X, Jiang Y, Zhang T, Suo C, Li X, Cheng L, Zhang Z, Niu H, Li Z, Xie Z, Shi H, Zhang X, Fan M, Wang X, Yang Y, Dang J, McConnell C, Zhang J, Wang J, Yu S, Ye W, Gao Y, Zhang K, Liu R, Jin L. Chen X, et al. Nat Commun. 2020 Jul 21;11(1):3475. doi: 10.1038/s41467-020-17316-z. Nat Commun. 2020. PMID: 32694610 Free PMC article.
Corrigendum.
[No authors listed] [No authors listed] Exp Biol Med (Maywood). 2018 Jul;243(11):963. doi: 10.1177/1535370218786118. Epub 2018 Jun 22. Exp Biol Med (Maywood). 2018. PMID: 29933712 Free PMC article.
Liu J, Fei L, Huang G-Q, Shang X-K, Liu M, Pei Z-J, Zhang Y-X. Right ventricle performances with echocardiography and (99m)Tc myocardial perfusion imaging in pulmonary arterial hypertension patients. ...
Liu J, Fei L, Huang G-Q, Shang X-K, Liu M, Pei Z-J, Zhang Y-X. Right ventricle performances with echocardiography and ( …
175 results