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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 2
1976 1
1977 2
1981 1
1983 1
1986 1
1989 1
1992 1
1993 1
1994 2
1995 1
1996 2
1997 3
1998 5
1999 1
2000 4
2001 3
2002 5
2003 7
2004 7
2005 3
2006 3
2007 1
2008 2
2009 3
2010 4
2011 4
2012 3
2013 3
2014 4
2015 3
2016 4
2017 3
2018 6
2019 5
2020 2
2021 7
2022 8
2023 8
2024 6

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125 results

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Page 1
Base editing of haematopoietic stem cells rescues sickle cell disease in mice.
Newby GA, Yen JS, Woodard KJ, Mayuranathan T, Lazzarotto CR, Li Y, Sheppard-Tillman H, Porter SN, Yao Y, Mayberry K, Everette KA, Jang Y, Podracky CJ, Thaman E, Lechauve C, Sharma A, Henderson JM, Richter MF, Zhao KT, Miller SM, Wang T, Koblan LW, McCaffrey AP, Tisdale JF, Kalfa TA, Pruett-Miller SM, Tsai SQ, Weiss MJ, Liu DR. Newby GA, et al. Nature. 2021 Jul;595(7866):295-302. doi: 10.1038/s41586-021-03609-w. Epub 2021 Jun 2. Nature. 2021. PMID: 34079130 Free PMC article.
We used a custom adenine base editor (ABE8e-NRCH)(2,3) to convert the SCD allele (HBB(S)) into Makassar beta-globin (HBB(G)), a non-pathogenic variant(4,5). Ex vivo delivery of mRNA encoding the base editor with a targeting guide RNA into haematopoietic stem and pro …
We used a custom adenine base editor (ABE8e-NRCH)(2,3) to convert the SCD allele (HBB(S)) into Makassar beta-globin (HBB(G)), a …
Na+/H+ antiporters.
Krulwich TA. Krulwich TA. Biochim Biophys Acta. 1983 Dec 30;726(4):245-64. doi: 10.1016/0304-4173(83)90011-3. Biochim Biophys Acta. 1983. PMID: 6320869 Review.
Na+/H+ antiports or exchange reactions have been found widely, if not ubiquitously, in prokaryotic and eukaryotic membranes. In any given experimental system, the multiplicity of ion conductance pathways and the absence of specific inhibitors complicate efforts to establis …
Na+/H+ antiports or exchange reactions have been found widely, if not ubiquitously, in prokaryotic and eukaryotic membranes. In any given ex …
Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.
King AJ, Siegel M, He Y, Nie B, Wang J, Koo-McCoy S, Minassian NA, Jafri Q, Pan D, Kohler J, Kumaraswamy P, Kozuka K, Lewis JG, Dragoli D, Rosenbaum DP, O'Neill D, Plain A, Greasley PJ, Jönsson-Rylander AC, Karlsson D, Behrendt M, Strömstedt M, Ryden-Bergsten T, Knöpfel T, Pastor Arroyo EM, Hernando N, Marks J, Donowitz M, Wagner CA, Alexander RT, Caldwell JS. King AJ, et al. Sci Transl Med. 2018 Aug 29;10(456):eaam6474. doi: 10.1126/scitranslmed.aam6474. Sci Transl Med. 2018. PMID: 30158152 Free PMC article. Clinical Trial.
We investigated the mechanism by which tenapanor reduces gastrointestinal phosphate uptake, using in vivo studies in rodents and translational experiments on human small intestinal stem cell-derived enteroid monolayers to model ion transport physiology. We found tha …
We investigated the mechanism by which tenapanor reduces gastrointestinal phosphate uptake, using in vivo studies in rodents and translation …
Calcium in the Backstage of Malaria Parasite Biology.
de Oliveira LS, Alborghetti MR, Carneiro RG, Bastos IMD, Amino R, Grellier P, Charneau S. de Oliveira LS, et al. Front Cell Infect Microbiol. 2021 Jul 28;11:708834. doi: 10.3389/fcimb.2021.708834. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34395314 Free PMC article. Review.
The calcium ion (Ca(2+)) is a ubiquitous second messenger involved in key biological processes in prokaryotes and eukaryotes. ...It is also proposed that a cross-talk among kinases, which are not members of the family of Ca(2+)-dependent protein kinases, such as protein ki …
The calcium ion (Ca(2+)) is a ubiquitous second messenger involved in key biological processes in prokaryotes and eukaryotes. ...It i …
Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico.
Dunkle LM, Kotloff KL, Gay CL, Áñez G, Adelglass JM, Barrat Hernández AQ, Harper WL, Duncanson DM, McArthur MA, Florescu DF, McClelland RS, Garcia-Fragoso V, Riesenberg RA, Musante DB, Fried DL, Safirstein BE, McKenzie M, Jeanfreau RJ, Kingsley JK, Henderson JA, Lane DC, Ruíz-Palacios GM, Corey L, Neuzil KM, Coombs RW, Greninger AL, Hutter J, Ake JA, Smith K, Woo W, Cho I, Glenn GM, Dubovsky F; 2019nCoV-301 Study Group. Dunkle LM, et al. N Engl J Med. 2022 Feb 10;386(6):531-543. doi: 10.1056/NEJMoa2116185. Epub 2021 Dec 15. N Engl J Med. 2022. PMID: 34910859 Free PMC article. Clinical Trial.
Clinical Features, Neuropathology, and Surgical Outcome in Patients With Refractory Epilepsy and Brain Somatic Variants in the SLC35A2 Gene.
Barba C, Blumcke I, Winawer MR, Hartlieb T, Kang HC, Grisotto L, Chipaux M, Bien CG, Heřmanovská B, Porter BE, Lidov HGW, Cetica V, Woermann FG, Lopez-Rivera JA, Canoll PD, Mader I, D'Incerti L, Baldassari S, Yang E, Gaballa A, Vogel H, Straka B, Macconi L, Polster T, Grant GA, Krsková L, Shin HJ, Ko A, Crino PB, Krsek P, Lee JH, Lal D, Baulac S, Poduri A, Guerrini R; SLC35A2 Study Group. Barba C, et al. Neurology. 2023 Jan 31;100(5):e528-e542. doi: 10.1212/WNL.0000000000201471. Epub 2022 Oct 28. Neurology. 2023. PMID: 36307217 Free PMC article.
Steroid-based anion receptors and transporters.
Brotherhood PR, Davis AP. Brotherhood PR, et al. Chem Soc Rev. 2010 Oct;39(10):3633-47. doi: 10.1039/b926225n. Epub 2010 Aug 11. Chem Soc Rev. 2010. PMID: 20714471 Review.
Anion binding and transport are important goals of supramolecular chemistry, especially in light of the potential for biological activity. Success depends on scaffolds which can preorganise polar functionality for anion recognition, and can maintain the right physical prop …
Anion binding and transport are important goals of supramolecular chemistry, especially in light of the potential for biological acti …
Genetic Basis of Left Ventricular Noncompaction.
Rojanasopondist P, Nesheiwat L, Piombo S, Porter GA Jr, Ren M, Phoon CKL. Rojanasopondist P, et al. Circ Genom Precis Med. 2022 Jun;15(3):e003517. doi: 10.1161/CIRCGEN.121.003517. Epub 2022 May 12. Circ Genom Precis Med. 2022. PMID: 35549379
Possible physiological roles of mitochondrial uncoupling proteins--UCPn.
Jezek P. Jezek P. Int J Biochem Cell Biol. 2002 Oct;34(10):1190-206. doi: 10.1016/s1357-2725(02)00061-4. Int J Biochem Cell Biol. 2002. PMID: 12127570 Review.
An obesity reduction in middle-aged humans was associated with the less common allele of -866 G/A polymorphism in the ucp2 gene promoter enhancing the exon 8 insertion: deletion transcript ratio. ...
An obesity reduction in middle-aged humans was associated with the less common allele of -866 G/A polymorphism in the ucp2 gen …
The common -866 G/A polymorphism in the promoter of uncoupling protein 2 is associated with increased carbohydrate and decreased lipid oxidation in juvenile obesity.
Le Fur S, Le Stunff C, Dos Santos C, Bougnères P. Le Fur S, et al. Diabetes. 2004 Jan;53(1):235-9. doi: 10.2337/diabetes.53.1.235. Diabetes. 2004. PMID: 14693721
Although its physiological role remains to be established, UCP2 is considered a candidate gene for association with energy metabolism and obesity. A common promoter polymorphism, -866 G/A, has been associated with increased UCP2 gene expression and middle-aged adult …
Although its physiological role remains to be established, UCP2 is considered a candidate gene for association with energy metabolism and ob …
125 results