Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages.
Sake SM, Kosch C, Blockus S, Haid S, Gunesch AP, Zhang X, Friesland M, Trummer SB, Grethe C, Kühnel A, Rückert J, Duprex WP, Huang J, Rameix-Welti MA, Empting M, Fischer N, Hirsch AKH, Schulz TF, Pietschmann T.
Sake SM, et al.
Antimicrob Agents Chemother. 2022 Dec 20;66(12):e0103222. doi: 10.1128/aac.01032-22. Epub 2022 Nov 8.
Antimicrob Agents Chemother. 2022.
PMID: 36346232
Free PMC article.
One compound, identified in the second round of infection, did not measurably inhibit hRSV cell entry or replication/transcription. It selected for two coding mutations in the G protein and was highly active in differentiated BCi-NS1.1 lung cells. ...
One compound, identified in the second round of infection, did not measurably inhibit hRSV cell entry or replication/transcription. It selec …