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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1991 2
1992 1
1993 2
1995 3
1996 2
1997 4
1999 1
2000 5
2001 10
2002 6
2003 2
2004 6
2005 8
2006 9
2007 14
2008 14
2009 13
2010 15
2011 22
2012 27
2013 41
2014 49
2015 67
2016 63
2017 73
2018 92
2019 99
2020 114
2021 113
2022 155
2023 123
2024 77

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1,076 results

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Page 1
Retraction.
[No authors listed] [No authors listed] Biofactors. 2023 Jan;49(1):188. doi: 10.1002/biof.1894. Epub 2022 Oct 14. Biofactors. 2023. PMID: 36239325
Fu, Q , Zhang, J , Huang, G , et al. microRNA-29b inhibits cell growth and promotes sensitivity to oxaliplatin in colon cancer by targeting FOLR1. ...
Fu, Q , Zhang, J , Huang, G , et al. microRNA-29b inhibits cell growth and promotes sensitivity to oxaliplatin in colon …
Structure, function and pharmacology of human itch GPCRs.
Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL. Cao C, et al. Nature. 2021 Dec;600(7887):170-175. doi: 10.1038/s41586-021-04126-6. Epub 2021 Nov 17. Nature. 2021. PMID: 34789874 Free PMC article.
Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-mediated hypersensitivity reactions(2-5). MRGPRX2 couples to both G(i) and G(q) in mast cells(6). Here we describe agonist-stabilized structures of MR …
Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-mediated hypersensitivity react …
Molecular basis for selective activation of DREADD-based chemogenetics.
Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL. Zhang S, et al. Nature. 2022 Dec;612(7939):354-362. doi: 10.1038/s41586-022-05489-0. Epub 2022 Nov 30. Nature. 2022. PMID: 36450989
The muscarinic receptor-based DREADDs are the most widely used chemogenetic tools in neuroscience research. The G(q)-coupled DREADD (hM3Dq) is used to enhance neuronal activity, whereas the G(i/o)-coupled DREADD (hM4Di) is utilized to inhibit neuronal activit …
The muscarinic receptor-based DREADDs are the most widely used chemogenetic tools in neuroscience research. The G(q)-coupled D …
Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma.
Zhang Y, Chen L, Hu GQ, Zhang N, Zhu XD, Yang KY, Jin F, Shi M, Chen YP, Hu WH, Cheng ZB, Wang SY, Tian Y, Wang XC, Sun Y, Li JG, Li WF, Li YH, Tang LL, Mao YP, Zhou GQ, Sun R, Liu X, Guo R, Long GX, Liang SQ, Li L, Huang J, Long JH, Zang J, Liu QD, Zou L, Su QF, Zheng BM, Xiao Y, Guo Y, Han F, Mo HY, Lv JW, Du XJ, Xu C, Liu N, Li YQ, Chua MLK, Xie FY, Sun Y, Ma J. Zhang Y, et al. N Engl J Med. 2019 Sep 19;381(12):1124-1135. doi: 10.1056/NEJMoa1905287. Epub 2019 May 31. N Engl J Med. 2019. PMID: 31150573 Clinical Trial.
Patients with locoregionally advanced nasopharyngeal carcinoma were randomly assigned in a 1:1 ratio to receive gemcitabine (at a dose of 1 g per square meter of body-surface area on days 1 and 8) plus cisplatin (80 mg per square meter on day 1), administered every 3 weeks …
Patients with locoregionally advanced nasopharyngeal carcinoma were randomly assigned in a 1:1 ratio to receive gemcitabine (at a dose of 1 …
Corrigendum.
[No authors listed] [No authors listed] Exp Biol Med (Maywood). 2018 Jul;243(11):963. doi: 10.1177/1535370218786118. Epub 2018 Jun 22. Exp Biol Med (Maywood). 2018. PMID: 29933712 Free PMC article.
Liu J, Fei L, Huang G-Q, Shang X-K, Liu M, Pei Z-J, Zhang Y-X. Right ventricle performances with echocardiography and (99m)Tc myocardial perfusion imaging in pulmonary arterial hypertension patients. ...
Liu J, Fei L, Huang G-Q, Shang X-K, Liu M, Pei Z-J, Zhang Y-X. Right ventricle performances with echocardiography and ( …
Structural insights into adhesion GPCR ADGRL3 activation and G(q), G(s), G(i), and G(12) coupling.
Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y. Qian Y, et al. Mol Cell. 2022 Nov 17;82(22):4340-4352.e6. doi: 10.1016/j.molcel.2022.10.009. Epub 2022 Oct 28. Mol Cell. 2022. PMID: 36309016 Free article.
Here, we present cryoelectron microscopy (cryo-EM) structures of ADGRL3 in complex with G(q), G(s), G(i), and G(12). The structures reveal unique ligand-engaging mode, distinctive activation conformation, and key mechanisms of aGPCR activation. …
Here, we present cryoelectron microscopy (cryo-EM) structures of ADGRL3 in complex with G(q), G(s), G(i), and …
Diet and Risk of Incident Lung Cancer: A Large Prospective Cohort Study in UK Biobank.
Wei X, Zhu C, Ji M, Fan J, Xie J, Huang Y, Jiang X, Xu J, Yin R, Du L, Wang Y, Dai J, Jin G, Xu L, Hu Z, Shen H, Zhu M, Ma H. Wei X, et al. Am J Clin Nutr. 2021 Dec 1;114(6):2043-2051. doi: 10.1093/ajcn/nqab298. Am J Clin Nutr. 2021. PMID: 34582556 Free article.
The association analysis showed high intake of red meat and processed meat was associated with an increased risk of lung cancer (HRper 50 g/d: 1.36; 95% CI: 1.13, 1.65 for red meat; HRper 25 g/d: 1.30; 95% CI: 1.10, 1.53 for processed meat). However, the consumption …
The association analysis showed high intake of red meat and processed meat was associated with an increased risk of lung cancer (HRper 50 …
Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke.
Yang P, Zhang Y, Zhang L, Zhang Y, Treurniet KM, Chen W, Peng Y, Han H, Wang J, Wang S, Yin C, Liu S, Wang P, Fang Q, Shi H, Yang J, Wen C, Li C, Jiang C, Sun J, Yue X, Lou M, Zhang M, Shu H, Sun D, Liang H, Li T, Guo F, Ke K, Yuan H, Wang G, Yang W, Shi H, Li T, Li Z, Xing P, Zhang P, Zhou Y, Wang H, Xu Y, Huang Q, Wu T, Zhao R, Li Q, Fang Y, Wang L, Lu J, Li Y, Fu J, Zhong X, Wang Y, Wang L, Goyal M, Dippel DWJ, Hong B, Deng B, Roos YBWEM, Majoie CBLM, Liu J; DIRECT-MT Investigators. Yang P, et al. N Engl J Med. 2020 May 21;382(21):1981-1993. doi: 10.1056/NEJMoa2001123. Epub 2020 May 6. N Engl J Med. 2020. PMID: 32374959 Clinical Trial.
Myogenic Vasoconstriction Requires Canonical G(q/11) Signaling of the Angiotensin II Type 1 Receptor.
Cui Y, Kassmann M, Nickel S, Zhang C, Alenina N, Anistan YM, Schleifenbaum J, Bader M, Welsh DG, Huang Y, Gollasch M. Cui Y, et al. J Am Heart Assoc. 2022 Feb 15;11(4):e022070. doi: 10.1161/JAHA.121.022070. Epub 2022 Feb 8. J Am Heart Assoc. 2022. PMID: 35132870 Free PMC article.
Methods and Results We tested the mechanosensitive function of AT1R using tamoxifen-inducible smooth muscle-specific AT1aR knockout (smooth muscle-Agtr1a(-/-)) mice and studied downstream signaling cascades mediated by G(q/11) and/or beta-arrestins. FR900359, Sar1Il …
Methods and Results We tested the mechanosensitive function of AT1R using tamoxifen-inducible smooth muscle-specific AT1aR knockout (smooth …
1,076 results