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Showing results for G. morikis
Your search for G. Moridis retrieved no results
Conformational heterogeneity in CCR7 undergoes transitions to specific states upon ligand binding.
Gaieb Z, Morikis D. Gaieb Z, et al. J Mol Graph Model. 2017 Jun;74:352-358. doi: 10.1016/j.jmgm.2017.04.012. Epub 2017 Apr 13. J Mol Graph Model. 2017. PMID: 28477575
Ligand-binding to G protein-coupled receptors (GPCRs) acts as the local driving force that initiates signal transduction through the receptor and mediates its conformational transitions and interactions with various intracellular effectors. In a recent study, We have shown …
Ligand-binding to G protein-coupled receptors (GPCRs) acts as the local driving force that initiates signal transduction through the …
Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant.
Rosenberg EM Jr, Harrison RES, Tsou LK, Drucker N, Humphries B, Rajasekaran D, Luker KE, Wu CH, Song JS, Wang CJ, Murphy JW, Cheng YC, Shia KS, Luker GD, Morikis D, Lolis EJ. Rosenberg EM Jr, et al. Cell Chem Biol. 2019 May 16;26(5):662-673.e7. doi: 10.1016/j.chembiol.2019.01.012. Epub 2019 Feb 28. Cell Chem Biol. 2019. PMID: 30827936 Free PMC article.
The G protein-coupled receptor (GPCR) CXCR4 is a co-receptor for HIV and is involved in cancers and autoimmune diseases. ...
The G protein-coupled receptor (GPCR) CXCR4 is a co-receptor for HIV and is involved in cancers and autoimmune diseases. ...
Hybrid flagellin as a T cell independent vaccine scaffold.
Bennett KM, Gorham RD Jr, Gusti V, Trinh L, Morikis D, Lo DD. Bennett KM, et al. BMC Biotechnol. 2015 Aug 12;15:71. doi: 10.1186/s12896-015-0194-0. BMC Biotechnol. 2015. PMID: 26265529 Free PMC article.
Detection of Side Chain Rearrangements Mediating the Motions of Transmembrane Helices in Molecular Dynamics Simulations of G Protein-Coupled Receptors.
Gaieb Z, Morikis D. Gaieb Z, et al. Comput Struct Biotechnol J. 2017 Jan 14;15:131-137. doi: 10.1016/j.csbj.2017.01.001. eCollection 2017. Comput Struct Biotechnol J. 2017. PMID: 28149485 Free PMC article.
This computational framework is suitable for the study of tightly packed proteins, such as G protein-coupled receptors, and we present an application on a seven microseconds MD trajectory of CC chemokine receptor 7 (CCR7) bound to its ligand CCL21....
This computational framework is suitable for the study of tightly packed proteins, such as G protein-coupled receptors, and we presen …
Molecular Mechanism of Biased Ligand Conformational Changes in CC Chemokine Receptor 7.
Gaieb Z, Lo DD, Morikis D. Gaieb Z, et al. J Chem Inf Model. 2016 Sep 26;56(9):1808-22. doi: 10.1021/acs.jcim.6b00367. Epub 2016 Aug 26. J Chem Inf Model. 2016. PMID: 27529431
Biased ligand binding to G protein-coupled receptors enables functional selectivity of intracellular effectors to mediate cellular function. Despite the significant advances made in characterizing the conformational states (transmembrane helical arrangements) capable of di …
Biased ligand binding to G protein-coupled receptors enables functional selectivity of intracellular effectors to mediate cellular fu …
Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling.
Croker DE, Monk PN, Halai R, Kaeslin G, Schofield Z, Wu MC, Clark RJ, Blaskovich MA, Morikis D, Floudas CA, Cooper MA, Woodruff TM. Croker DE, et al. Immunol Cell Biol. 2016 Sep;94(8):787-95. doi: 10.1038/icb.2016.43. Epub 2016 Apr 25. Immunol Cell Biol. 2016. PMID: 27108698 Free article.
The complement activation peptide, C5a, binds two seven transmembrane receptors, namely the C5a receptor 1 (C5aR1) and C5a receptor 2 (C5aR2, or C5L2). C5aR2 is a non-G-protein-signalling receptor whose biological role remains controversial. ...
The complement activation peptide, C5a, binds two seven transmembrane receptors, namely the C5a receptor 1 (C5aR1) and C5a receptor 2 (C5aR2 …
Neutrophil Mechanosignaling Promotes Integrin Engagement With Endothelial Cells and Motility Within Inflamed Vessels.
Morikis VA, Simon SI. Morikis VA, et al. Front Immunol. 2018 Nov 28;9:2774. doi: 10.3389/fimmu.2018.02774. eCollection 2018. Front Immunol. 2018. PMID: 30546362 Free PMC article. Clinical Trial.
This occurs through cooperation between at least four families of adhesion molecules and G-protein coupled signaling receptors. These adhesion molecules convert the drag force induced by blood flow acting on the cell surface into bond tension that resists detachment. ...
This occurs through cooperation between at least four families of adhesion molecules and G-protein coupled signaling receptors. These …
Hydrogen exchange in the carbon monoxide complex of soybean leghemoglobin.
Morikis D, Wright PE. Morikis D, et al. Eur J Biochem. 1996 Apr 1;237(1):212-20. doi: 10.1111/j.1432-1033.1996.0212n.x. Eur J Biochem. 1996. PMID: 8620875 Free article.
The data are consistent with the presence of transient cooperative local unfolding of helical segments. The B-, E-, G- and H-helices have extensive regions of slow-, medium- and fast-exchanging amide protons. ...A strong tertiary contact has been established between the A- …
The data are consistent with the presence of transient cooperative local unfolding of helical segments. The B-, E-, G- and H-helices …
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