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Page 1
Local mobility in amorphous pharmaceuticals--characterization and implications on stability.
Bhattacharya S, Suryanarayanan R. Bhattacharya S, et al. J Pharm Sci. 2009 Sep;98(9):2935-53. doi: 10.1002/jps.21728. J Pharm Sci. 2009. PMID: 19499564 Review.
Generally, information on the mobility of an amorphous pharmaceutical below the glass transition temperature (T(g)) has been obtained by extrapolation of data from above T(g). ...
Generally, information on the mobility of an amorphous pharmaceutical below the glass transition temperature (T(g)) has been obtained …
Stabilization of Amorphous Drugs by Polymers: The Role of Overlap Concentration (C*).
Sahoo A, Suryanarayanan R, Siegel RA. Sahoo A, et al. Mol Pharm. 2020 Nov 2;17(11):4401-4406. doi: 10.1021/acs.molpharmaceut.0c00576. Epub 2020 Oct 9. Mol Pharm. 2020. PMID: 32975418
XRD also showed that crystallization was completely inhibited up to T(g) + 75 C when the polymer concentration was above C*. Our results suggest that stabilization of amorphous drugs can be achieved by incorporating a polymer just above C*, which is much lower than polymer …
XRD also showed that crystallization was completely inhibited up to T(g) + 75 C when the polymer concentration was above C*. Our resu …
Ethanol-induced plasticity of GABAA receptors in the basolateral amygdala.
Lindemeyer AK, Liang J, Marty VN, Meyer EM, Suryanarayanan A, Olsen RW, Spigelman I. Lindemeyer AK, et al. Neurochem Res. 2014 Jun;39(6):1162-70. doi: 10.1007/s11064-014-1297-z. Epub 2014 Apr 8. Neurochem Res. 2014. PMID: 24710789 Free PMC article.
In the present study we assessed the changes in cell surface levels of select GABAAR subunits in the BLA of a rat model of alcohol dependence induced by chronic intermittent EtOH (CIE) treatment and long-term (>40 days) withdrawal and investigated the time-course of such chang …
In the present study we assessed the changes in cell surface levels of select GABAAR subunits in the BLA of a rat model of alcohol dependenc …
Subtraction of DC conductivity and annealing: approaches to identify Johari-Goldstein relaxation in amorphous trehalose.
Bhardwaj SP, Suryanarayanan R. Bhardwaj SP, et al. Mol Pharm. 2011 Aug 1;8(4):1416-22. doi: 10.1021/mp2000154. Epub 2011 Jun 30. Mol Pharm. 2011. PMID: 21639143
Isothermal dielectric relaxation profiles of amorphous trehalose were obtained, over the frequency range of 10(-1)-10(7) Hz, and at temperatures ranging from 30-170 C. At temperatures close to the glass transition (T(g)), the alpha-relaxation was not readily discernible du …
Isothermal dielectric relaxation profiles of amorphous trehalose were obtained, over the frequency range of 10(-1)-10(7) Hz, and at temperat …
Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice.
Chandra D, Werner DF, Liang J, Suryanarayanan A, Harrison NL, Spigelman I, Olsen RW, Homanics GE. Chandra D, et al. Alcohol Clin Exp Res. 2008 Jan;32(1):10-8. doi: 10.1111/j.1530-0277.2007.00563.x. Epub 2007 Dec 12. Alcohol Clin Exp Res. 2008. PMID: 18076749 Free PMC article.
We compared behavioral responses to EtOH in alpha 4 knockout and wild-type littermates in the elevated plus maze (0.0, 1.0 g/kg EtOH), screen test (1.5, 2.0 g/kg), hypothermia (1.5, 2.0 g/kg), fixed speed rotarod (1.5, 2.0, 2.5 g/kg), open field (0.0, …
We compared behavioral responses to EtOH in alpha 4 knockout and wild-type littermates in the elevated plus maze (0.0, 1.0 g/kg EtOH) …
Role of interleukin-10 (IL-10) in regulation of GABAergic transmission and acute response to ethanol.
Suryanarayanan A, Carter JM, Landin JD, Morrow AL, Werner DF, Spigelman I. Suryanarayanan A, et al. Neuropharmacology. 2016 Aug;107:181-188. doi: 10.1016/j.neuropharm.2016.03.027. Epub 2016 Mar 22. Neuropharmacology. 2016. PMID: 27016017 Free PMC article.
In the present study, we show that IL-10 is increased early (1 h) after a single intoxicating dose of EtOH (5 g/kg, intragastric) in Sprague Dawley rats. We also show that IL-10 rapidly regulates GABAergic transmission in dentate gyrus neurons. ...
In the present study, we show that IL-10 is increased early (1 h) after a single intoxicating dose of EtOH (5 g/kg, intragastric) in …
Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication.
Liang J, Suryanarayanan A, Abriam A, Snyder B, Olsen RW, Spigelman I. Liang J, et al. J Neurosci. 2007 Nov 7;27(45):12367-77. doi: 10.1523/JNEUROSCI.2786-07.2007. J Neurosci. 2007. PMID: 17989301 Free PMC article.
A cross-linking assay and Western blot analysis of microdissected CA1 area of hippocampal slices obtained 1 h after EtOH intoxication (5 g/kg, gavage), revealed decreases in the cell-surface fraction of alpha4 and delta, but not alpha1, alpha5, or gamma2 GABA(A)R subunits, …
A cross-linking assay and Western blot analysis of microdissected CA1 area of hippocampal slices obtained 1 h after EtOH intoxication (5 …
Plasticity of GABA(A) receptor-mediated neurotransmission in the nucleus accumbens of alcohol-dependent rats.
Liang J, Lindemeyer AK, Suryanarayanan A, Meyer EM, Marty VN, Ahmad SO, Shao XM, Olsen RW, Spigelman I. Liang J, et al. J Neurophysiol. 2014 Jul 1;112(1):39-50. doi: 10.1152/jn.00565.2013. Epub 2014 Apr 2. J Neurophysiol. 2014. PMID: 24694935 Free PMC article.
Similar, but reversible, alterations occurred after a single ethanol dose (5 g/kg). These data reveal CIE-induced long-lasting neuroadaptations in the NAcc GABAergic neurotransmission....
Similar, but reversible, alterations occurred after a single ethanol dose (5 g/kg). These data reveal CIE-induced long-lasting neuroa …
Effect of Dispersoid on Sulfonium Ionic Liquid Based Gel Polymer Electrolyte for Lithium Secondary Battery.
Muthupradeepa R, Sivakumar M, Subadevi R, Suryanarayanan V, Liu WR. Muthupradeepa R, et al. J Nanosci Nanotechnol. 2018 Jan 1;18(1):215-222. doi: 10.1166/jnn.2018.14601. J Nanosci Nanotechnol. 2018. PMID: 29768833
Coin cell containing Li anode and LiFePO4 cathode along with polymer electrolyte/6 wt% TiO2 filler, delivers a first discharge capacity of 145 mAh/g with the working voltage of 3.4 V....
Coin cell containing Li anode and LiFePO4 cathode along with polymer electrolyte/6 wt% TiO2 filler, delivers a first discharge capacity of 1 …
Correlation between molecular mobility and physical stability of amorphous itraconazole.
Bhardwaj SP, Arora KK, Kwong E, Templeton A, Clas SD, Suryanarayanan R. Bhardwaj SP, et al. Mol Pharm. 2013 Feb 4;10(2):694-700. doi: 10.1021/mp300487u. Epub 2013 Jan 8. Mol Pharm. 2013. PMID: 23198856
Above T(g), nonlinear temperature dependence of the alpha-relaxation was described by the Vogel-Tammann-Fulcher (VTF) model. ...Primary relaxation appeared to be the mobility responsible for the observed physical instability at temperatures above T(g) as indicated b …
Above T(g), nonlinear temperature dependence of the alpha-relaxation was described by the Vogel-Tammann-Fulcher (VTF) model. ...Prima …
26 results