Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
2000 1
2001 1
2003 1
2004 1
2005 2
2007 2
2008 2
2009 2
2010 1
2011 3
2012 2
2013 2
2014 4
2015 1
2017 2
2018 3
2019 2
2021 3
2022 2
2023 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

36 results

Results by year

Filters applied: . Clear all
Page 1
A structural analysis of G-quadruplex/ligand interactions.
Haider SM, Neidle S, Parkinson GN. Haider SM, et al. Biochimie. 2011 Aug;93(8):1239-51. doi: 10.1016/j.biochi.2011.05.012. Epub 2011 May 26. Biochimie. 2011. PMID: 21635933 Review.
In contrast to duplex DNA, G-quadruplexes are four-stranded nucleic acid structures folded from guanine rich repeat sequences stabilized by the stacking of guanine G-quartets and extensive Watson-Crick/Hoogsteen hydrogen bonding. Thermally stable, these topologies c …
In contrast to duplex DNA, G-quadruplexes are four-stranded nucleic acid structures folded from guanine rich repeat sequences stabili …
Molecular crowding promotes the aggregation of parallel structured G-quadruplexes.
Gao C, Deng J, Anwar N, Umer M, Chen J, Wu Q, Dong X, Xu H, He Y, Wang Z. Gao C, et al. Int J Biol Macromol. 2023 Jun 15;240:124442. doi: 10.1016/j.ijbiomac.2023.124442. Epub 2023 Apr 14. Int J Biol Macromol. 2023. PMID: 37062387
Thus, studying the interaction mechanism between ligands and parallel structured G-quadruplexes under crowding conditions is crucial for the design of drugs targeting G-quadruplexes. ...Further studies showed that molecular crowding did not alter the binding stoichi …
Thus, studying the interaction mechanism between ligands and parallel structured G-quadruplexes under crowding conditions is crucial …
Effects of the central potassium ions on the G-quadruplex and stabilizer binding.
Wang Z, Liu JP. Wang Z, et al. J Mol Graph Model. 2017 Mar;72:168-177. doi: 10.1016/j.jmgm.2017.01.006. Epub 2017 Jan 6. J Mol Graph Model. 2017. PMID: 28092835
The K(+) above the top G-tetrad is prone to leak into environment and the 5'-adenine quickly flips over the top G-tetrad, leading to the bottom gate of G-tetrads as the only viable pathway of K(+) binding. ...Our findings provide further insights into the reg …
The K(+) above the top G-tetrad is prone to leak into environment and the 5'-adenine quickly flips over the top G-tetrad, lead …
Pediatric Mobile Health Care Delivery During COVID-19.
Nass M, Chase T, Buncher N, Gonzalez P, Quino G, Gurnani P, Bair-Merritt M, Kistin C. Nass M, et al. Acad Pediatr. 2022 Jul;22(5):873-875. doi: 10.1016/j.acap.2022.02.014. Epub 2022 Feb 24. Acad Pediatr. 2022. PMID: 35219853 Free PMC article. No abstract available.
Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition.
Corey L, Gilbert PB, Juraska M, Montefiori DC, Morris L, Karuna ST, Edupuganti S, Mgodi NM, deCamp AC, Rudnicki E, Huang Y, Gonzales P, Cabello R, Orrell C, Lama JR, Laher F, Lazarus EM, Sanchez J, Frank I, Hinojosa J, Sobieszczyk ME, Marshall KE, Mukwekwerere PG, Makhema J, Baden LR, Mullins JI, Williamson C, Hural J, McElrath MJ, Bentley C, Takuva S, Gomez Lorenzo MM, Burns DN, Espy N, Randhawa AK, Kochar N, Piwowar-Manning E, Donnell DJ, Sista N, Andrew P, Kublin JG, Gray G, Ledgerwood JE, Mascola JR, Cohen MS; HVTN 704/HPTN 085 and HVTN 703/HPTN 081 Study Teams. Corey L, et al. N Engl J Med. 2021 Mar 18;384(11):1003-1014. doi: 10.1056/NEJMoa2031738. N Engl J Med. 2021. PMID: 33730454 Free PMC article. Clinical Trial.
Pharmacodynamics of the G-quadruplex-stabilizing telomerase inhibitor 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in vitro: activity in human tumor cells correlates with telomere length and can be enhanced, or antagonized, with cytotoxic agents.
Cookson JC, Dai F, Smith V, Heald RA, Laughton CA, Stevens MF, Burger AM. Cookson JC, et al. Mol Pharmacol. 2005 Dec;68(6):1551-8. doi: 10.1124/mol.105.013300. Epub 2005 Sep 8. Mol Pharmacol. 2005. PMID: 16150933
Telomeric integrity is required to maintain the replicative ability of cancer cells and is a target for the G-quadruplex-stabilizing drug 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4). ...These observations are consistent with loss …
Telomeric integrity is required to maintain the replicative ability of cancer cells and is a target for the G-quadruplex-stabilizing …
Studies on the Interactions of 3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium and Insulin with the Quadruplex-Forming Oligonucleotide Sequence a2 from the Insulin-Linked Polymorphic Region.
Wickhorst PJ, Ihmels H, Paululat T. Wickhorst PJ, et al. Molecules. 2021 Oct 30;26(21):6595. doi: 10.3390/molecules26216595. Molecules. 2021. PMID: 34771003 Free PMC article.
In this context, this contribution reports on the investigation of the association of the quadruplex-forming ILPR sequence a2 with insulin as well as with the well-known G4-DNA ligand 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium (1), also named RHPS4, by opt …
In this context, this contribution reports on the investigation of the association of the quadruplex-forming ILPR sequence a2 with insulin a …
Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration.
Leonetti C, Amodei S, D'Angelo C, Rizzo A, Benassi B, Antonelli A, Elli R, Stevens MF, D'Incalci M, Zupi G, Biroccio A. Leonetti C, et al. Mol Pharmacol. 2004 Nov;66(5):1138-46. doi: 10.1124/mol.104.001537. Epub 2004 Aug 10. Mol Pharmacol. 2004. PMID: 15304549
This study had two goals: 1) to evaluate the biological effect of the novel pentacyclic acridine 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) on human melanoma lines possessing long telomeres, and 2) to elucidate the relationship between …
This study had two goals: 1) to evaluate the biological effect of the novel pentacyclic acridine 3,11-difluoro-6,8,13-trimethyl-8H-quino …
Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry.
Pagano B , Iaccarino N , Di Porzio A , Randazzo A , Amato J . Pagano B , et al. Analyst. 2019 Nov 4;144(22):6512-6516. doi: 10.1039/c9an01463b. Analyst. 2019. PMID: 31602449
G-quadruplex (G4) nucleic acid structures are involved in a number of different diseases and their drug-induced stabilization is deemed to be a promising therapeutic approach. ...
G-quadruplex (G4) nucleic acid structures are involved in a number of different diseases and their drug-induced stabilization is deem …
36 results