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1988 1
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2003 1
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88 results

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Page 1
Dexamethasone in Hospitalized Patients with Covid-19.
RECOVERY Collaborative Group; Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffery K, Montgomery A, Rowan K, Juszczak E, Baillie JK, Haynes R, Landray MJ. RECOVERY Collaborative Group, et al. N Engl J Med. 2021 Feb 25;384(8):693-704. doi: 10.1056/NEJMoa2021436. Epub 2020 Jul 17. N Engl J Med. 2021. PMID: 32678530 Free PMC article. Clinical Trial.
Functional characterisation of G protein-coupled receptors.
Uddin R, Simms J, Poyner D. Uddin R, et al. Methods. 2018 Sep 1;147:213-220. doi: 10.1016/j.ymeth.2018.02.018. Epub 2018 Mar 3. Methods. 2018. PMID: 29510249 Review.
For GPCRs, the main measure of receptor activation is to investigate the association of the G protein with the receptor. The chief assay measures the receptor-stimulated binding of GTP or a suitable analogue to the receptor. The direct association of the G protein w …
For GPCRs, the main measure of receptor activation is to investigate the association of the G protein with the receptor. The chief as …
Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins.
Hay DL, Walker CS, Gingell JJ, Ladds G, Reynolds CA, Poyner DR. Hay DL, et al. Biochem Soc Trans. 2016 Apr 15;44(2):568-73. doi: 10.1042/BST20150237. Biochem Soc Trans. 2016. PMID: 27068971 Review.
Receptor activity-modifying proteins (RAMPs) are single pass membrane proteins initially identified by their ability to determine the pharmacology of the calcitonin receptor-like receptor (CLR), a family B G protein-coupled receptor (GPCR). It is now known that RAMPs can i …
Receptor activity-modifying proteins (RAMPs) are single pass membrane proteins initially identified by their ability to determine the pharma …
Expression and purification of recombinant G protein-coupled receptors: A review.
Wiseman DN, Otchere A, Patel JH, Uddin R, Pollock NL, Routledge SJ, Rothnie AJ, Slack C, Poyner DR, Bill RM, Goddard AD. Wiseman DN, et al. Protein Expr Purif. 2020 Mar;167:105524. doi: 10.1016/j.pep.2019.105524. Epub 2019 Oct 31. Protein Expr Purif. 2020. PMID: 31678667 Free PMC article. Review.
The effects of RAMPs upon cell signalling.
Routledge SJ, Ladds G, Poyner DR. Routledge SJ, et al. Mol Cell Endocrinol. 2017 Jul 5;449:12-20. doi: 10.1016/j.mce.2017.03.033. Epub 2017 Apr 5. Mol Cell Endocrinol. 2017. PMID: 28390954 Review.
G protein-coupled receptors (GPCRs) play a vital role in signal transduction. ...These interactions can influence cell surface expression, ligand binding preferences and G protein-coupling, thus modulating GPCR signal transduction. There is still a great deal of res
G protein-coupled receptors (GPCRs) play a vital role in signal transduction. ...These interactions can influence cell surface expres
Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group. Electronic address: recoverytrial@ndph.ox.ac.uk; RECOVERY Collaborative Group. RECOVERY Collaborative Group. Electronic address: recoverytrial@ndph.ox.ac.uk, et al. Lancet. 2023 May 6;401(10387):1499-1507. doi: 10.1016/S0140-6736(23)00510-X. Epub 2023 Apr 13. Lancet. 2023. PMID: 37060915 Free PMC article. Clinical Trial.
G-protein-coupled receptors: from structural insights to functional mechanisms.
Chini B, Parenti M, Poyner DR, Wheatley M. Chini B, et al. Biochem Soc Trans. 2013 Feb 1;41(1):135-6. doi: 10.1042/BST20120344. Biochem Soc Trans. 2013. PMID: 23356272 Review.
The papers resulting from the recent Biochemical Society Focused Meeting 'G-Protein-Coupled Receptors: from Structural Insights to Functional Mechanisms' held in Prato in September 2012 are introduced in the present overview. A number of future goals for GPCR (G-pro …
The papers resulting from the recent Biochemical Society Focused Meeting 'G-Protein-Coupled Receptors: from Structural Insights to Fu …
The activation of the CGRP receptor.
Barwell J, Wheatley M, Conner AC, Taddese B, Vohra S, Reynolds CA, Poyner DR. Barwell J, et al. Biochem Soc Trans. 2013 Feb 1;41(1):180-4. doi: 10.1042/BST20120251. Biochem Soc Trans. 2013. PMID: 23356280 Review.
The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). ...
The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calc …
88 results