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1953 1
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Page 1
Heterogeneity and transcriptional drivers of triple-negative breast cancer.
Jovanović B, Temko D, Stevens LE, Seehawer M, Fassl A, Murphy K, Anand J, Garza K, Gulvady A, Qiu X, Harper NW, Daniels VW, Xiao-Yun H, Ge JY, Alečković M, Pyrdol J, Hinohara K, Egri SB, Papanastasiou M, Vadhi R, Font-Tello A, Witwicki R, Peluffo G, Trinh A, Shu S, Diciaccio B, Ekram MB, Subedee A, Herbert ZT, Wucherpfennig KW, Letai AG, Jaffe JD, Sicinski P, Brown M, Dillon D, Long HW, Michor F, Polyak K. Jovanović B, et al. Cell Rep. 2023 Dec 26;42(12):113564. doi: 10.1016/j.celrep.2023.113564. Epub 2023 Dec 14. Cell Rep. 2023. PMID: 38100350 Free PMC article.
Next-generation drug repurposing using human genetics and network biology.
Nabirotchkin S, Peluffo AE, Rinaudo P, Yu J, Hajj R, Cohen D. Nabirotchkin S, et al. Curr Opin Pharmacol. 2020 Apr;51:78-92. doi: 10.1016/j.coph.2019.12.004. Epub 2020 Jan 22. Curr Opin Pharmacol. 2020. PMID: 31982325 Free article. Review.
Drug repurposing has attracted increased attention, especially in the context of drug discovery rates that remain too low despite a recent wave of approvals for biological therapeutics (e.g. gene therapy). These new biological entities-based treatments have high costs that …
Drug repurposing has attracted increased attention, especially in the context of drug discovery rates that remain too low despite a recent w …
Biochemistry of protein tyrosine nitration in cardiovascular pathology.
Peluffo G, Radi R. Peluffo G, et al. Cardiovasc Res. 2007 Jul 15;75(2):291-302. doi: 10.1016/j.cardiores.2007.04.024. Epub 2007 May 3. Cardiovasc Res. 2007. PMID: 17544386 Review.
Nitration of tyrosine can affect protein function, which could directly link nitroxidative stress to the molecular alterations found in disease. While some proteins are inactivated by nitration (e.g. Mn-SOD) others undergo a gain-of-function (e.g. fibrinogen) that c …
Nitration of tyrosine can affect protein function, which could directly link nitroxidative stress to the molecular alterations found in dise …
Protein tyrosine nitration in hydrophilic and hydrophobic environments.
Bartesaghi S, Ferrer-Sueta G, Peluffo G, Valez V, Zhang H, Kalyanaraman B, Radi R. Bartesaghi S, et al. Amino Acids. 2007;32(4):501-15. doi: 10.1007/s00726-006-0425-8. Epub 2006 Nov 2. Amino Acids. 2007. PMID: 17077966 Review.
We focused on mechanistic aspects, emphasizing on the free radical mechanisms of protein 3-nitrotyrosine formation and critically analyzed the restrictions for obtaining large tyrosine nitration yields in vivo, mainly due to the presence of strong reducing systems (e.g. gl …
We focused on mechanistic aspects, emphasizing on the free radical mechanisms of protein 3-nitrotyrosine formation and critically analyzed t …
Remediation of phenanthrene-contaminated soil by simultaneous persulfate chemical oxidation and biodegradation processes.
Mora VC, Madueño L, Peluffo M, Rosso JA, Del Panno MT, Morelli IS. Mora VC, et al. Environ Sci Pollut Res Int. 2014 Jun;21(12):7548-56. doi: 10.1007/s11356-014-2687-0. Epub 2014 Mar 6. Environ Sci Pollut Res Int. 2014. PMID: 24595755
Soil microcosms contaminated with 140 mg/kgDRY SOIL of phenanthrene were treated with different persulfate (PS) concentrations 0.86-41.7 g/kgDRY SOIL and incubated for 28 days. Analyses of phenanthrene and persulfate concentrations and soil pH were performed. ...
Soil microcosms contaminated with 140 mg/kgDRY SOIL of phenanthrene were treated with different persulfate (PS) concentrations 0.86-41.7 …
Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis.
Gandelman M, Peluffo H, Beckman JS, Cassina P, Barbeito L. Gandelman M, et al. J Neuroinflammation. 2010 Jun 9;7:33. doi: 10.1186/1742-2094-7-33. J Neuroinflammation. 2010. PMID: 20534165 Free PMC article.
Involvement of P2X(7) receptor was further confirmed by Brilliant blue G inhibition of ATP and BzATP effects. In SOD1G93A astrocyte cultures, pharmacological inhibition of P2X(7) receptor or increased extracellular ATP degradation with the enzyme apyrase was sufficient to …
Involvement of P2X(7) receptor was further confirmed by Brilliant blue G inhibition of ATP and BzATP effects. In SOD1G93A astrocyte c …
Effect of L-triiodothyronine on liver microsomal delta 6 and delta 5 desaturase activity of male rats.
Ves-Losada A, Peluffo RO. Ves-Losada A, et al. Mol Cell Biochem. 1993 Apr 21;121(2):149-53. doi: 10.1007/BF00925974. Mol Cell Biochem. 1993. PMID: 8316232
The activity of delta 6 and delta 5 desaturases was decreased 24 and 28%, respectively, in animals administered a daily intraperitoneal dose of 1000 micrograms T3/100 g body wt. for 5 days, whereas with 500 micrograms T3/100 g body wt. only delta 6 desaturase activi …
The activity of delta 6 and delta 5 desaturases was decreased 24 and 28%, respectively, in animals administered a daily intraperitoneal dose …