Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.
Sarthy AV, Morgan-Lappe SE, Zakula D, Vernetti L, Schurdak M, Packer JC, Anderson MG, Shirasawa S, Sasazuki T, Fesik SW.
Sarthy AV, et al.
Mol Cancer Ther. 2007 Jan;6(1):269-76. doi: 10.1158/1535-7163.MCT-06-0560.
Mol Cancer Ther. 2007.
PMID: 17237286
Free article.
We found that siRNAs targeting baculoviral inhibitor of apoptosis repeat-containing 5 (survivin) significantly reduced the survival of activated K-Ras-transformed cells compared with its normal isogenic counterpart in which the mutant K-Ras gene had been disrupted (DKS-8). In add …
We found that siRNAs targeting baculoviral inhibitor of apoptosis repeat-containing 5 (survivin) significantly reduced the survival of activ …