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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 2
1954 1
1963 5
1964 4
1965 2
1966 2
1967 2
1968 2
1969 1
1971 1
1972 1
1973 4
1974 1
1975 5
1976 9
1977 4
1978 7
1979 2
1980 8
1981 11
1982 4
1983 2
1984 12
1985 5
1986 10
1987 16
1988 9
1989 14
1990 13
1991 22
1992 13
1993 23
1994 15
1995 14
1996 18
1997 37
1998 30
1999 34
2000 52
2001 63
2002 75
2003 83
2004 99
2005 94
2006 136
2007 127
2008 167
2009 162
2010 208
2011 237
2012 229
2013 305
2014 405
2015 385
2016 449
2017 416
2018 446
2019 495
2020 565
2021 609
2022 553
2023 570
2024 182

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6,638 results

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Page 1
G(q)-Mediated Arrhythmogenic Signaling Promotes Atrial Fibrillation.
Hohendanner F, Prabhu A, Wilck N, Stangl V, Pieske B, Stangl K, Althoff TF. Hohendanner F, et al. Biomedicines. 2023 Feb 11;11(2):526. doi: 10.3390/biomedicines11020526. Biomedicines. 2023. PMID: 36831062 Free PMC article.
Baseline electrophysiological properties, including heart rate, sinus node recovery time, and atrial as well as AV nodal effective refractory periods, were comparable in G(q)-KO and control mice. However, inducibility and mean duration of AF episodes were significan …
Baseline electrophysiological properties, including heart rate, sinus node recovery time, and atrial as well as AV nodal effective refractor …
G-protein coupled receptor 19 (GPR19) knockout mice display sex-dependent metabolic dysfunction.
Mushala BAS, Xie B, Sipula IJ, Stoner MW, Thapa D, Manning JR, Bugga P, Vandevender AM, Jurczak MJ, Scott I. Mushala BAS, et al. Sci Rep. 2023 Apr 15;13(1):6134. doi: 10.1038/s41598-023-33308-7. Sci Rep. 2023. PMID: 37061564 Free PMC article.
G-protein coupled receptors (GPCRs) mediate signal transduction from the cellular surface to intracellular metabolic pathways. ...In this report, we use a novel knockout (KO) mouse model to examine the role of GPR19 in whole-body metabolic regulation. ...
G-protein coupled receptors (GPCRs) mediate signal transduction from the cellular surface to intracellular metabolic pathways. ...In …
Mice deficient for G-protein-coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall.
Speidell A, Walton S, Campbell LA, Tomassoni-Ardori F, Tessarollo L, Corbo C, Taraballi F, Mocchetti I. Speidell A, et al. J Neurochem. 2023 Jun;165(6):827-841. doi: 10.1111/jnc.15818. Epub 2023 Apr 21. J Neurochem. 2023. PMID: 36978267
There are a number of G-protein-coupled receptors (GPCRs) that are considered "orphan receptors" because the information on their known ligands is incomplete. ...To examine the functional consequence of this down-regulation, WT and GPR75 KO mice were tested on a hip …
There are a number of G-protein-coupled receptors (GPCRs) that are considered "orphan receptors" because the information on their kno …
Application of a JEG-3 organoid model to study HLA-G function in the trophoblast.
Zhuang BM, Cao DD, Liu XF, Wang L, Lin XL, Duan YG, Lee CL, Chiu PCN, Yeung WSB, Yao YQ. Zhuang BM, et al. Front Immunol. 2023 Mar 15;14:1130308. doi: 10.3389/fimmu.2023.1130308. eCollection 2023. Front Immunol. 2023. PMID: 37006248 Free PMC article.
In addition, neither HLA-G KO nor the exogenous addition of HLA-G protein during EVT differentiation from JEG-3-ORGs altered the temporal expression of the known EVT marker genes. Based on the JEG-3 KO (disruption of exons 2 and 3) cell line and the TB …
In addition, neither HLA-G KO nor the exogenous addition of HLA-G protein during EVT differentiation from JEG-3-ORGs al …
A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype.
Shah R, van den Berk PCM, Pritchard CEJ, Song JY, Kreft M, Pilzecker B, Jacobs H. Shah R, et al. Int J Mol Sci. 2023 Jul 5;24(13):11129. doi: 10.3390/ijms241311129. Int J Mol Sci. 2023. PMID: 37446306 Free PMC article.
Previous FANCG-deficient mouse models were generated with drug-based selection cassettes in mixed mice backgrounds, leading to a disparity in the interpretation of genotype-related phenotype. We created a Fancg-KO (KO) mouse model using CRISPR/Cas9 to exclude these …
Previous FANCG-deficient mouse models were generated with drug-based selection cassettes in mixed mice backgrounds, leading to a disparity i …
TRPC Channels Activated by G Protein-Coupled Receptors Drive Ca(2+) Dysregulation Leading to Secondary Brain Injury in the Mouse Model.
Parmar J, von Jonquieres G, Gorlamandala N, Chung B, Craig AJ, Pinyon JL, Birnbaumer L, Klugmann M, Moorhouse AJ, Power JM, Housley GD. Parmar J, et al. Transl Stroke Res. 2023 Jul 18. doi: 10.1007/s12975-023-01173-1. Online ahead of print. Transl Stroke Res. 2023. PMID: 37462831
Canonical transient receptor potential (TRPC) non-selective cation channels, particularly those assembled with TRPC3, TRPC6, and TRPC7 subunits, are coupled to G(alphaq)-type G protein-coupled receptors for the major classes of excitatory neurotransmitters. ...This …
Canonical transient receptor potential (TRPC) non-selective cation channels, particularly those assembled with TRPC3, TRPC6, and TRPC7 subun …
Ovarian cancer G protein-coupled receptor 1 deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice.
Yassini N, Sprenger J, Pastor Arroyo EM, Krudewig C, Pellegrini G, Joller N, Wagner CA, Imenez Silva PH. Yassini N, et al. Clin Sci (Lond). 2023 Jul 31;137(14):1013-1025. doi: 10.1042/CS20230421. Clin Sci (Lond). 2023. PMID: 37431800
Ovarian cancer G protein-coupled receptor 1 (OGR1) (Gpr68) and G protein-coupled receptor 4 (GPR4) (Gpr4) are proton-activated G protein-coupled receptors that are stimulated upon increased extracellular acidity. ...To address this, we investigated their role …
Ovarian cancer G protein-coupled receptor 1 (OGR1) (Gpr68) and G protein-coupled receptor 4 (GPR4) (Gpr4) are proton-activated …
Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation.
Hashimoto S, Matsuba Y, Takahashi M, Kamano N, Watamura N, Sasaguri H, Takado Y, Yoshihara Y, Saito T, Saido TC. Hashimoto S, et al. Sci Rep. 2023 Jan 20;13(1):1109. doi: 10.1038/s41598-023-27653-w. Sci Rep. 2023. PMID: 36670138 Free PMC article.
In particular, GSDME-deficiency significantly attenuated the hippocampal atrophy and changed levels of DAM markers in GCLC-KO mice. Finally, we found that the expression of GCLC was decreased around amyloid plaques in App(NL-G-F) AD model mice. App(NL-G-F) mo …
In particular, GSDME-deficiency significantly attenuated the hippocampal atrophy and changed levels of DAM markers in GCLC-KO mice. F …
Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (Rgs2) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice.
Ritter ML, Deng G, Reho JJ, Deng Y, Sapouckey SA, Opichka MA, Balapattabi K, Wackman KK, Brozoski DT, Lu KT, Paradee WJ, Gibson-Corley KN, Cui H, Nakagawa P, Morselli LL, Sigmund CD, Grobe JL. Ritter ML, et al. Hypertension. 2022 Dec;79(12):2843-2853. doi: 10.1161/HYPERTENSIONAHA.122.20169. Epub 2022 Oct 19. Hypertension. 2022. PMID: 36259376 Free PMC article.
BACKGROUND: RGS (regulator of G protein signaling) family members catalyze the termination of G protein signaling cascades. ...RESULTS: Whereas Rgs2(Flox), Rgs2(Agrp-KO), and BAC-AT(1A)-Cre mice exhibited normal growth and survival, Rgs2(AT1A-KO) exhib …
BACKGROUND: RGS (regulator of G protein signaling) family members catalyze the termination of G protein signaling cascades. .. …
PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKalpha1-INDEPENDENT MECHANISMS.
Wagner ML, Ammann A, Piraino G, Wolfe V, O'Connor M, Lahni P, Ziady A, Zingarelli B. Wagner ML, et al. Shock. 2023 Jul 1;60(1):64-74. doi: 10.1097/SHK.0000000000002134. Epub 2023 Apr 21. Shock. 2023. PMID: 37079467
Treatment with humanin-G improved lung injury, mean arterial blood pressure, and survival in both WT and KO mice, without affecting systemic cytokine or humanin levels. Humanin-G also ameliorated cardiac mitochondrial damage and increased adenosine triphospha …
Treatment with humanin-G improved lung injury, mean arterial blood pressure, and survival in both WT and KO mice, without affe …
6,638 results