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Page 1
In vitro cell migration and invasion assays.
Kramer N, Walzl A, Unger C, Rosner M, Krupitza G, Hengstschläger M, Dolznig H. Kramer N, et al. Mutat Res. 2013 Jan-Mar;752(1):10-24. doi: 10.1016/j.mrrev.2012.08.001. Epub 2012 Aug 23. Mutat Res. 2013. PMID: 22940039 Review.
We substantiate our choice by demonstrating that the advantages outbalance the drawbacks e.g. the simple setup, the easy readout, the kinetic analysis, the evaluation of cell morphology and the feasibility to perform the assay with standard laboratory equipment. ...
We substantiate our choice by demonstrating that the advantages outbalance the drawbacks e.g. the simple setup, the easy readout, the …
Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis.
Jayaram HN, Cooney DA, Grusch M, Krupitza G. Jayaram HN, et al. Curr Med Chem. 1999 Jul;6(7):561-74. Curr Med Chem. 1999. PMID: 10390601 Review.
Incomplete depletion of cellular GTP level seems to down-regulate G-protein function, thereby inhibit cell growth or induce apoptosis. ...
Incomplete depletion of cellular GTP level seems to down-regulate G-protein function, thereby inhibit cell growth or induce apoptosis …
Chemical Composition of Scrophularia lucida and the Effects on Tumor Invasiveness in Vitro.
Lewenhofer V, Schweighofer L, Ledermüller T, Eichsteininger J, Kählig H, Zehl M, Nguyen CH, Krupitza G, Özmen A, Krenn L. Lewenhofer V, et al. Front Pharmacol. 2018 Apr 3;9:304. doi: 10.3389/fphar.2018.00304. eCollection 2018. Front Pharmacol. 2018. PMID: 29666580 Free PMC article.
The study resulted in the identification of 14 substances, among them very rare iridoids, such as scrovalentinoside or koelzioside, and several flavonoids (e.g., nepitrin and homoplantaginin). One of the latter group, 2"-O-acetyl-homoplantaginin, is a new natural compound. …
The study resulted in the identification of 14 substances, among them very rare iridoids, such as scrovalentinoside or koelzioside, and seve …
Cdc25A phosphatase suppresses apoptosis induced by serum deprivation.
Fuhrmann G, Leisser C, Rosenberger G, Grusch M, Huettenbrenner S, Halama T, Mosberger I, Sasgary S, Cerni C, Krupitza G. Fuhrmann G, et al. Oncogene. 2001 Jul 27;20(33):4542-53. doi: 10.1038/sj.onc.1204499. Oncogene. 2001. PMID: 11494150
Inhibition of apoptosis by SU4984, NF023 and Rapamycin placed Cdc25A and Akt function downstream of FGF.R, PDGF.R, and compensated G-protein- and PP2A- activity. Interestingly, upon treatment with LY-294002, cdc25A- and akt- over-expressing clones exhibited similar apoptot …
Inhibition of apoptosis by SU4984, NF023 and Rapamycin placed Cdc25A and Akt function downstream of FGF.R, PDGF.R, and compensated G- …
In vitro anti-inflammatory and anticancer activities of extracts of Acalypha alopecuroidea (Euphorbiaceae).
Madlener S, Svacinová J, Kitner M, Kopecky J, Eytner R, Lackner A, Vo TP, Frisch R, Grusch M, De Martin R, Dolezal K, Strnad M, Krupitza G. Madlener S, et al. Int J Oncol. 2009 Oct;35(4):881-91. doi: 10.3892/ijo_00000403. Int J Oncol. 2009. PMID: 19724926
More than 60% of conventional drugs are derived from natural compounds, some of the most effective pharmaceuticals (e.g. aspirin, quinine and various antibiotics) originate from plants or microbes, and large numbers of potentially valuable natural substances remain to be d …
More than 60% of conventional drugs are derived from natural compounds, some of the most effective pharmaceuticals (e.g. aspirin, qui …
Autocrine self-elimination of cultured ovarian cancer cells by tumour necrosis factor alpha (TNF-alpha).
Simonitsch I, Krupitza G. Simonitsch I, et al. Br J Cancer. 1998 Oct;78(7):862-70. doi: 10.1038/bjc.1998.594. Br J Cancer. 1998. PMID: 9764576 Free PMC article.
To substitute the autocrine activity by a single physiological component, 28 cytokines, growth factors and biomodulators were tested [interleukin 1alpha (IL-1alpha), IL-1beta, IL-2, IL-3, IL-4, IL-6, IL-10, IL-11, stem cell factor (SCF), platelet-derived growth factor (PDGF), aci …
To substitute the autocrine activity by a single physiological component, 28 cytokines, growth factors and biomodulators were tested [interl …
The dichloromethane extract of the ethnomedicinal plant Neurolaena lobata inhibits NPM/ALK expression which is causal for anaplastic large cell lymphomagenesis.
Unger C, Popescu R, Giessrigl B, Laimer D, Heider S, Seelinger M, Diaz R, Wallnöfer B, Egger G, Hassler M, Knöfler M, Saleh L, Sahin E, Grusch M, Fritzer-Szekeres M, Dolznig H, Frisch R, Kenner L, Kopp B, Krupitza G. Unger C, et al. Int J Oncol. 2013 Jan;42(1):338-48. doi: 10.3892/ijo.2012.1690. Epub 2012 Nov 6. Int J Oncol. 2013. PMID: 23135783
The dichloromethane extract inhibited proliferation of HL-60, human and mouse ALCL cells with an IC50 of ~2.5, 3.7 and 2.4 g/ml, respectively and arrested cells in the G2/M phase. The extract induced the checkpoint kinases Chk1 and Chk2 and perturbed the orchestrated expre …
The dichloromethane extract inhibited proliferation of HL-60, human and mouse ALCL cells with an IC50 of ~2.5, 3.7 and 2.4 g/ml, resp …
Methanol extract of the ethnopharmaceutical remedy Smilax spinosa exhibits anti-neoplastic activity.
Seelinger M, Popescu R, Giessrigl B, Jarukamjorn K, Unger C, Wallnöfer B, Fritzer-Szekeres M, Szekeres T, Diaz R, Jäger W, Frisch R, Kopp B, Krupitza G. Seelinger M, et al. Int J Oncol. 2012 Sep;41(3):1164-72. doi: 10.3892/ijo.2012.1538. Epub 2012 Jun 29. Int J Oncol. 2012. PMID: 22752086
By using several solvents the methanol extract was by far the most potent against HL60 cell proliferation (50% inhibition at 60 g/ml). Furthermore, fractionation of this extract yielded fraction F2, which exhibited enforced pro-apoptotic activity, and activated CYP1A1. ...
By using several solvents the methanol extract was by far the most potent against HL60 cell proliferation (50% inhibition at 60 g/ml) …
A novel N-hydroxy-N'-aminoguanidine derivative inhibits ribonucleotide reductase activity: Effects in human HL-60 promyelocytic leukemia cells and synergism with arabinofuranosylcytosine (Ara-C).
Saiko P, Graser G, Giessrigl B, Lackner A, Grusch M, Krupitza G, Basu A, Sinha BN, Jayaprakash V, Jaeger W, Fritzer-Szekeres M, Szekeres T. Saiko P, et al. Biochem Pharmacol. 2011 Jan 1;81(1):50-9. doi: 10.1016/j.bcp.2010.09.006. Epub 2010 Sep 16. Biochem Pharmacol. 2011. PMID: 20849828