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The neuroanatomical substrates of autism and ADHD and their link to putative genomic underpinnings.
Berg LM, Gurr C, Leyhausen J, Seelemeyer H, Bletsch A, Schaefer T, Pretzsch CM, Oakley B, Loth E, Floris DL, Buitelaar JK, Beckmann CF, Banaschewski T, Charman T, Jones EJH, Tillmann J, Chatham CH, Bourgeron T; EU-AIMS LEAP Group; Murphy DG, Ecker C. Berg LM, et al. Mol Autism. 2023 Oct 4;14(1):36. doi: 10.1186/s13229-023-00568-z. Mol Autism. 2023. PMID: 37794485 Free PMC article.
The ABC of Phytohormone Translocation.
Hellsberg E, Montanari F, Ecker GF. Hellsberg E, et al. Planta Med. 2015 Apr;81(6):474-87. doi: 10.1055/s-0035-1545880. Epub 2015 Apr 23. Planta Med. 2015. PMID: 25905596 Free PMC article. Review.
Analogous transporters are also known to be involved in phytohormone translocation. These include, e.g., the transport of auxin by ABCB1/19 in Arabidopsis thaliana, the transport of abscisic acid by AtABCG25, and the transport of strigolactone by the Petunia hybrida ABC tr …
Analogous transporters are also known to be involved in phytohormone translocation. These include, e.g., the transport of auxin by AB …
Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors.
Dvorak V, Casiraghi A, Colas C, Koren A, Tomek T, Offensperger F, Rukavina A, Tin G, Hahn E, Dobner S, Frommelt F, Boeszoermenyi A, Bernada V, Hannich JT, Ecker GF, Winter GE, Kubicek S, Superti-Furga G. Dvorak V, et al. Cell Chem Biol. 2023 Aug 17;30(8):953-964.e9. doi: 10.1016/j.chembiol.2023.06.029. Epub 2023 Jul 28. Cell Chem Biol. 2023. PMID: 37516113 Free PMC article.
Human Immune Cell Epigenomic Signatures in Response to Infectious Diseases and Chemical Exposures.
Wang W, Hariharan M, Bartlett A, Barragan C, Castanon R, Rothenberg V, Song H, Nery J, Aldridge A, Altshul J, Kenworthy M, Ding W, Liu H, Tian W, Zhou J, Chen H, Wei B, Gündüz IB, Norell T, Broderick TJ, McClain MT, Satterwhite LL, Burke TW, Petzold EA, Shen X, Woods CW, Fowler VG Jr, Ruffin F, Panuwet P, Barr DB, Beare JL, Smith AK, Spurbeck RR, Vangeti S, Ramos I, Nudelman G, Sealfon SC, Castellino F, Walley AM, Evans T, Müller F, Greenleaf WJ, Ecker JR. Wang W, et al. bioRxiv [Preprint]. 2023 Jun 30:2023.06.29.546792. doi: 10.1101/2023.06.29.546792. bioRxiv. 2023. PMID: 37425926 Free PMC article. Preprint.
Cross-sectional and longitudinal neuroanatomical profiles of distinct clinical (adaptive) outcomes in autism.
Pretzsch CM, Floris DL, Schäfer T, Bletsch A, Gurr C, Lombardo MV, Chatham CH, Tillmann J, Charman T, Arenella M, Jones E, Ambrosino S, Bourgeron T, Dumas G, Cliquet F, Leblond CS, Loth E, Oakley B, Buitelaar JK, Baron-Cohen S, Beckmann CF, Persico AM, Banaschewski T, Durston S, Freitag CM; EU-AIMS/AIMS-2-TRIALS Consortium; Murphy DGM, Ecker C. Pretzsch CM, et al. Mol Psychiatry. 2023 May;28(5):2158-2169. doi: 10.1038/s41380-023-02016-z. Epub 2023 Mar 29. Mol Psychiatry. 2023. PMID: 36991132 Free PMC article.
These profiles were enriched for genes previously associated with autism and for genes previously linked to neurobiological pathways implicated in autism (e.g. excitation-inhibition systems). Our findings suggest that distinct clinical outcomes (i.e. intra-individual chang …
These profiles were enriched for genes previously associated with autism and for genes previously linked to neurobiological pathways implica …
Predicting ligand interactions with ABC transporters in ADME.
Demel MA, Krämer O, Ettmayer P, Haaksma EE, Ecker GF. Demel MA, et al. Chem Biodivers. 2009 Nov;6(11):1960-9. doi: 10.1002/cbdv.200900138. Chem Biodivers. 2009. PMID: 19937827 Review.
ABC-type drug efflux pumps, e.g., ABCB1 (=P-glycoprotein, =MDR1), ABCC1 (=MRP1), and ABCG2 (=MXR, =BCRP), confer a multi-drug resistance (MDR) phenotype to cancer cells. ...
ABC-type drug efflux pumps, e.g., ABCB1 (=P-glycoprotein, =MDR1), ABCC1 (=MRP1), and ABCG2 (=MXR, =BCRP), confer a multi-drug resista …
In silico prediction models for blood-brain barrier permeation.
Ecker GF, Noe CR. Ecker GF, et al. Curr Med Chem. 2004 Jun;11(12):1617-28. doi: 10.2174/0929867043365071. Curr Med Chem. 2004. PMID: 15180567 Review.
Starting with simple regression models based on calculation of lipophilicity and polar surface area, the field developed via PLS methods to grid based approaches (e.g. VolSurf). Additionally, the use of artificial neural networks gain increasing importance. ...
Starting with simple regression models based on calculation of lipophilicity and polar surface area, the field developed via PLS methods to …
Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1.
Singh N, Ecker GF. Singh N, et al. Int J Mol Sci. 2018 Apr 24;19(5):1278. doi: 10.3390/ijms19051278. Int J Mol Sci. 2018. PMID: 29695141 Free PMC article. Review.
The large neutral amino acid transporter 1 (LAT1, or SLC7A5) is a sodium- and pH-independent transporter, which supplies essential amino acids (e.g., leucine, phenylalanine) to cells. It plays an important role at the Blood-Brain Barrier (BBB) where it facilitates the tran …
The large neutral amino acid transporter 1 (LAT1, or SLC7A5) is a sodium- and pH-independent transporter, which supplies essential amino aci …
A Robust, Mechanistically Based In Silico Structural Profiler for Hepatic Cholestasis.
Firman JW, Pestana CB, Rathman JF, Vinken M, Yang C, Cronin MTD. Firman JW, et al. Chem Res Toxicol. 2021 Feb 15;34(2):641-655. doi: 10.1021/acs.chemrestox.0c00465. Epub 2020 Dec 14. Chem Res Toxicol. 2021. PMID: 33314907
Drawing upon a list of >1500 small molecular drugs, compiled and annotated by Kotsampasakou, E. and Ecker, G. F. (J. Chem. Inf. Model. 2017, 57, 608-615), we have formulated a series of 15 structural alerts. ...
Drawing upon a list of >1500 small molecular drugs, compiled and annotated by Kotsampasakou, E. and Ecker, G. F. (J. …
Neurobiological Correlates of Change in Adaptive Behavior in Autism.
Pretzsch CM, Schäfer T, Lombardo MV, Warrier V, Mann C, Bletsch A, Chatham CH, Floris DL, Tillmann J, Yousaf A, Jones E, Charman T, Ambrosino S, Bourgeron T, Dumas G, Loth E, Oakley B, Buitelaar JK, Cliquet F, Leblond CS, Baron-Cohen S, Beckmann CF, Banaschewski T, Durston S, Freitag CM; EU-AIMS LEAP Group; Murphy DGM, Ecker C. Pretzsch CM, et al. Am J Psychiatry. 2022 May;179(5):336-349. doi: 10.1176/appi.ajp.21070711. Epub 2022 Mar 25. Am J Psychiatry. 2022. PMID: 35331004
Moreover, neuroanatomical differences were associated with genetic processes relevant to neuroanatomical phenotypes (e.g., synaptic development). CONCLUSIONS: This study demonstrates, for the first time, that variation in clinical (adaptive) outcome is associated with both …
Moreover, neuroanatomical differences were associated with genetic processes relevant to neuroanatomical phenotypes (e.g., synaptic d …
34 results