In vitro response of osteoarthritic chondrocytes and fibroblast-like synoviocytes to a 500-730 kDa hyaluronan amide derivative.
Brun P, Zavan B, Vindigni V, Schiavinato A, Pozzuoli A, Iacobellis C, Abatangelo G.
Brun P, et al.
J Biomed Mater Res B Appl Biomater. 2012 Nov;100(8):2073-81. doi: 10.1002/jbm.b.32771. Epub 2012 Aug 2.
J Biomed Mater Res B Appl Biomater. 2012.
PMID: 22865740
Clinical Trial.
At 0.5 to 1 mg mL(-1) , HA and HYADD4-G did not influence the proliferation of normal or pathological FLS; however, at the higher concentration (1.5 mg mL(-1) ), HYADD4-G did significantly inhibit cell proliferation. ...The longer residence time in the joint cavity, …
At 0.5 to 1 mg mL(-1) , HA and HYADD4-G did not influence the proliferation of normal or pathological FLS; however, at the higher con …