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Showing results for furin wei
Search for Fuyin Wei instead (1 results)
Plasma Proteomics to Identify Drug Targets for Ischemic Heart Disease.
Mazidi M, Wright N, Yao P, Kartsonaki C, Millwood IY, Fry H, Said S, Pozarickij A, Pei P, Chen Y, Avery D, Du H, Schmidt DV, Yang L, Lv J, Yu C, Chen J, Hill M, Holmes MV, Howson JMM, Peto R, Collins R, Bennett DA, Walters RG, Li L, Clarke R, Chen Z; China Kadoorie Biobank Collaborative Group. Mazidi M, et al. J Am Coll Cardiol. 2023 Nov 14;82(20):1906-1920. doi: 10.1016/j.jacc.2023.09.804. J Am Coll Cardiol. 2023. PMID: 37940228 Free PMC article.
Independent MR analyses of 307 cis-pQTLs identified in Europeans replicated associations for 4 proteins (FURIN, proteinase-activated receptor-1, Asialoglycoprotein receptor-1, and matrix metalloproteinase-3). Further downstream analyses showed that FURIN, which is h …
Independent MR analyses of 307 cis-pQTLs identified in Europeans replicated associations for 4 proteins (FURIN, proteinase-activated …
Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells via Hippo-YAP pathway.
Zhang Y, Zhou M, Wei H, Zhou H, He J, Lu Y, Wang D, Chen B, Zeng J, Peng W, Du F, Gong A, Xu M. Zhang Y, et al. Int J Oncol. 2017 Apr;50(4):1352-1362. doi: 10.3892/ijo.2017.3896. Epub 2017 Mar 2. Int J Oncol. 2017. PMID: 28259973
However, the role of furin in pancreatic cancer progression remains to be elucidated. ...Furthermore, our data showed that Furin knockdown, furin inhibitor D6R or overexpression significantly affected YAP phosphoration level and total YAP protein level, indic …
However, the role of furin in pancreatic cancer progression remains to be elucidated. ...Furthermore, our data showed that Furin …
Self-Assembly of Amphiphilic Peptides for Recognizing High Furin-Expressing Cancer Cells.
Li X, Cao C, Wei P, Xu M, Liu Z, Liu L, Zhong Y, Li R, Zhou Y, Yi T. Li X, et al. ACS Appl Mater Interfaces. 2019 Apr 3;11(13):12327-12334. doi: 10.1021/acsami.9b01281. Epub 2019 Mar 20. ACS Appl Mater Interfaces. 2019. PMID: 30864434
The C-3 nanostructures thus can selectively distinguish high furin-expressing cancer cells, like MDA-MB-231 cells, a kind of human breast cancer cells, from normal cells. Furthermore, the C-3 self-assembly can stay in living cells for a long time and are capable of durable …
The C-3 nanostructures thus can selectively distinguish high furin-expressing cancer cells, like MDA-MB-231 cells, a kind of human br …
Pathway-related molecules of VEGFC/D-VEGFR3/NRP2 axis in tumor lymphangiogenesis and lymphatic metastasis.
Wang J, Huang Y, Zhang J, Wei Y, Mahoud S, Bakheet AM, Wang L, Zhou S, Tang J. Wang J, et al. Clin Chim Acta. 2016 Oct 1;461:165-71. doi: 10.1016/j.cca.2016.08.008. Epub 2016 Aug 12. Clin Chim Acta. 2016. PMID: 27527412 Review.
In lymphangiogenesis and lymphatic metastasis, the pathway-related molecules of VEGFC/D-VEGFR3/NRP2 axis, such as Furin-like enzyme, CNTN1, Prox1, LYVE-1, Podoplanin, SOX18, SDF1 and CXCR4, are direct constitutors as a portion of VEGFC/D-VEGFR3/NRP2 axis, and their biologi …
In lymphangiogenesis and lymphatic metastasis, the pathway-related molecules of VEGFC/D-VEGFR3/NRP2 axis, such as Furin-like enzyme, …
Furin inhibitor D6R suppresses epithelial-mesenchymal transition in SW1990 and PaTu8988 cells via the Hippo-YAP signaling pathway.
Zhou M, Zhang Y, Wei H, He J, Wang D, Chen B, Zeng J, Gong A, Xu M. Zhou M, et al. Oncol Lett. 2018 Mar;15(3):3192-3196. doi: 10.3892/ol.2017.7672. Epub 2017 Dec 20. Oncol Lett. 2018. PMID: 29435056 Free PMC article.
Hexa-D-arginine (D6R), an inhibitor of furin, has potential therapeutic applications in different types of human tumor. ...
Hexa-D-arginine (D6R), an inhibitor of furin, has potential therapeutic applications in different types of human tumor. ...
Furin substrate as a novel cell-penetrating peptide: combining a delivery vector and an inducer of cargo release.
Cao C, Sheng D, Li X, Xue F, Liu L, Zhong Y, Wei P, Li R, Yi T. Cao C, et al. Chem Commun (Camb). 2019 Oct 1;55(79):11872-11875. doi: 10.1039/c9cc02353d. Chem Commun (Camb). 2019. PMID: 31528875
We have developed a new cell-penetrating peptide (CPP) using a repeated protease (furin) substrate. This CPP can not only deliver cargo into cells but can also be cleaved by furin in cells and release the cargo. ...
We have developed a new cell-penetrating peptide (CPP) using a repeated protease (furin) substrate. This CPP can not only deliver car …
Increased Cleavage of Japanese Encephalitis Virus prM Protein Promotes Viral Replication but Attenuates Virulence.
Xiong J, Yan M, Zhu S, Zheng B, Wei N, Yang L, Si Y, Cao S, Ye J. Xiong J, et al. Microbiol Spectr. 2022 Jun 29;10(3):e0141722. doi: 10.1128/spectrum.01417-22. Epub 2022 Jun 13. Microbiol Spectr. 2022. PMID: 35695552 Free PMC article.
However, the detailed relationship between viral replication or pathogenicity and furin in Japanese encephalitis virus (JEV) hasn't been clarified. ...During the viral maturation process, prM is cleaved into M by the cellular endoprotease furin in the acidic secreto …
However, the detailed relationship between viral replication or pathogenicity and furin in Japanese encephalitis virus (JEV) hasn't b …
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O'Shea JJ. Pesu M, et al. Nature. 2008 Sep 11;455(7210):246-50. doi: 10.1038/nature07210. Nature. 2008. PMID: 18701887 Free PMC article.
Furin is one of seven proprotein convertase family members that promote proteolytic maturation of proproteins. ...Targeting furin has emerged as a strategy in malignant and infectious disease. ...
Furin is one of seven proprotein convertase family members that promote proteolytic maturation of proproteins. ...Targeting furin …
Methyl-CpG-binding protein 2 drives the Furin/TGF-beta1/Smad axis to promote epithelial-mesenchymal transition in pancreatic cancer cells.
Wang H, Li J, He J, Liu Y, Feng W, Zhou H, Zhou M, Wei H, Lu Y, Peng W, Du F, Gong A, Xu M. Wang H, et al. Oncogenesis. 2020 Aug 26;9(8):76. doi: 10.1038/s41389-020-00258-y. Oncogenesis. 2020. PMID: 32848128 Free PMC article.
In addition, we found that MeCP2 upregulated the expression of Furin, activated TGF-beta1, and increased the levels of p-Smad2/3. Importantly, we demonstrated that MeCP2, as a coactivator, enhanced Smad3 binding to the furin promoter to improve its transcription. Th …
In addition, we found that MeCP2 upregulated the expression of Furin, activated TGF-beta1, and increased the levels of p-Smad2/3. Imp …
Structural insights into the effect of mutations in the spike protein of SARS-CoV-2 on the binding with human furin protein.
Suleman M, Luqman M, Wei DQ, Ali S, Ali SS, Khan A, Khan H, Ali Z, Khan W, Rizwan M, Ullah N. Suleman M, et al. Heliyon. 2023 Apr;9(4):e15083. doi: 10.1016/j.heliyon.2023.e15083. Epub 2023 Mar 31. Heliyon. 2023. PMID: 37064465 Free PMC article.
Protein-protein docking and molecular simulation analysis with that of furin have predicted that all the mutants enhanced the binding efficiency however, the V622F mutant has greatly altered the binding capacity which is further verified by the K(D) value (7.1 E(-14)) and …
Protein-protein docking and molecular simulation analysis with that of furin have predicted that all the mutants enhanced the binding …
28 results