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Showing results for fusing luo
Search for Futing Luo instead (1 results)
CRISPR-assisted transcription activation by phase-separation proteins.
Liu J, Chen Y, Nong B, Luo X, Cui K, Li Z, Zhang P, Tan W, Yang Y, Ma W, Liang P, Songyang Z. Liu J, et al. Protein Cell. 2023 Dec 1;14(12):874-887. doi: 10.1093/procel/pwad013. Protein Cell. 2023. PMID: 36905356 Free PMC article.
Current CRISPR-activation (CRISPRa) platforms often require multiple components because of inefficient transcriptional activation. Here, we fused different phase-separation proteins to dCas9-VPR (dCas9-VP64-P65-RTA) and observed robust increases in transcriptional activati …
Current CRISPR-activation (CRISPRa) platforms often require multiple components because of inefficient transcriptional activation. Here, we …
Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase.
Tong H, Wang X, Liu Y, Liu N, Li Y, Luo J, Ma Q, Wu D, Li J, Xu C, Yang H. Tong H, et al. Nat Biotechnol. 2023 Aug;41(8):1080-1084. doi: 10.1038/s41587-022-01595-6. Epub 2023 Jan 9. Nat Biotechnol. 2023. PMID: 36624150
Here we developed an adenine transversion base editor, AYBE, for A-to-C and A-to-T transversion editing in mammalian cells by fusing an adenine base editor (ABE) with hypoxanthine excision protein N-methylpurine DNA glycosylase (MPG). ...
Here we developed an adenine transversion base editor, AYBE, for A-to-C and A-to-T transversion editing in mammalian cells by fusing …
Generation of vascularized brain organoids to study neurovascular interactions.
Sun XY, Ju XC, Li Y, Zeng PM, Wu J, Zhou YY, Shen LB, Dong J, Chen YJ, Luo ZG. Sun XY, et al. Elife. 2022 May 4;11:e76707. doi: 10.7554/eLife.76707. Elife. 2022. PMID: 35506651 Free PMC article.
In this study, we induced vessel and brain organoids, respectively, and then fused two types of organoids together to obtain vascularized brain organoids. ...To overcome these limitations, Sun, Ju et al. developed brain organoids and blood vessel organoids independently, a …
In this study, we induced vessel and brain organoids, respectively, and then fused two types of organoids together to obtain vascular …
Double π-Extended Undecabenzo[7]helicene.
Chen Y, Lin C, Luo Z, Yin Z, Shi H, Zhu Y, Wang J. Chen Y, et al. Angew Chem Int Ed Engl. 2021 Mar 29;60(14):7796-7801. doi: 10.1002/anie.202014621. Epub 2021 Feb 26. Angew Chem Int Ed Engl. 2021. PMID: 33410247
This work reports the first double pi-extended undecabenzo[7]helicene 1, which is a large chiral nanographene, composed of 65 fused rings and 186 conjugated carbon atoms. The molecular identity of 1 has been confirmed by single crystal X-ray diffraction. ...
This work reports the first double pi-extended undecabenzo[7]helicene 1, which is a large chiral nanographene, composed of 65 fused r …
(1R*,5S*)-8-(2-Fluoro-4-nitro-phen-yl)-8-aza-bicyclo-[3.2.1]octan-3-one.
Yang T, Yang J, Li Z, Luo Y. Yang T, et al. Acta Crystallogr Sect E Struct Rep Online. 2011 Dec 1;67(Pt 12):o3297. doi: 10.1107/S1600536811047350. Epub 2011 Nov 12. Acta Crystallogr Sect E Struct Rep Online. 2011. PMID: 22199799 Free PMC article.
In the title compound, C(13)H(13)FN(2)O(3), the fused piperidine ring is in a chair conformation. The fused pyrrolidine ring shows an envelope conformation with the N atom displaced by 0.661 (3) A out of the plane formed by the four C atoms of the pyrrolidine ring. …
In the title compound, C(13)H(13)FN(2)O(3), the fused piperidine ring is in a chair conformation. The fused pyrrolidine ring s …
Deacetyl-nomilin monohydrate.
Li GQ, Ye YS, Yang YT, Luo HJ, Li YL. Li GQ, et al. Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):o2561. doi: 10.1107/S1600536811035033. Epub 2011 Sep 3. Acta Crystallogr Sect E Struct Rep Online. 2011. PMID: 22065825 Free PMC article.
In the title compound (systematic name 1-hy-droxy-1,2-dihydro-obacunoic acid 3,4-lactone monohydrate), C(26)H(32)O(8).H(2)O, the dihedral angles between the planes of the ester groups and the furan plane are 43.06 (12) and 56.06 (7), while that between the furan plane and the ket …
In the title compound (systematic name 1-hy-droxy-1,2-dihydro-obacunoic acid 3,4-lactone monohydrate), C(26)H(32)O(8).H(2)O, the dihedral an …
Combination immunotherapy of glioblastoma with dendritic cell cancer vaccines, anti-PD-1 and poly I:C.
Zhu P, Li SY, Ding J, Fei Z, Sun SN, Zheng ZH, Wei D, Jiang J, Miao JL, Li SZ, Luo X, Zhang K, Wang B, Zhang K, Pu S, Wang QT, Zhang XY, Wen GL, Liu JO, August JT, Bian H, Chen ZN, He YW. Zhu P, et al. J Pharm Anal. 2023 Jun;13(6):616-624. doi: 10.1016/j.jpha.2023.04.012. Epub 2023 Apr 21. J Pharm Anal. 2023. PMID: 37440907 Free PMC article.
Furthermore, mRNA-TAAs were modified with a novel TriVac technology that fuses TAAs with a destabilization domain and inserts TAAs into full-length lysosomal associated membrane protein-1 to enhance major histocompatibility complex (MHC) class I and II antigen presentation …
Furthermore, mRNA-TAAs were modified with a novel TriVac technology that fuses TAAs with a destabilization domain and inserts TAAs in …
[Recent advances in CRISPR-related transposable elements].
Ning S, Wu X, Luo Y. Ning S, et al. Sheng Wu Gong Cheng Xue Bao. 2022 Dec 25;38(12):4371-4384. doi: 10.13345/j.cjb.220197. Sheng Wu Gong Cheng Xue Bao. 2022. PMID: 36593183 Free article. Review. Chinese.
This review summarized the research progress and application development of natural CRISPR-related transposable elements in recent years, as well as the applications of fused dCas9-transposase. It proposed the application prospects and potential challenges of CRISPR-relate …
This review summarized the research progress and application development of natural CRISPR-related transposable elements in recent years, as …
Cell-penetrating Peptides: Efficient Vectors for Vaccine Delivery.
Yang J, Luo Y, Shibu MA, Toth I, Skwarczynskia M. Yang J, et al. Curr Drug Deliv. 2019;16(5):430-443. doi: 10.2174/1567201816666190123120915. Curr Drug Deliv. 2019. PMID: 30760185 Free PMC article. Review.
Cell-penetrating peptides (CPPs) are especially attractive component of antigen delivery systems as they have been widely used to enhance drug transport into the cells. Fusing or co-delivery of antigen with CPPs can enhance antigen uptake, processing and presentation by an …
Cell-penetrating peptides (CPPs) are especially attractive component of antigen delivery systems as they have been widely used to enhance dr …
Generation of Human Blood Vessel and Vascularized Cerebral Organoids.
Sun XY, Ju XC, Zhao HF, You ZW, Han RR, Luo ZG. Sun XY, et al. Bio Protoc. 2023 Nov 5;13(21):e4870. doi: 10.21769/BioProtoc.4870. eCollection 2023 Nov 5. Bio Protoc. 2023. PMID: 37969757 Free PMC article.
We developed this protocol to generate brain-specific blood vessel and cerebral organoids and then fused them at a specific developmental time point. The fused cerebral organoids exhibited robust vascular network-like structures, which allows simulating the in vivo …
We developed this protocol to generate brain-specific blood vessel and cerebral organoids and then fused them at a specific developme …
852 results