Xeniaphyllane-Derived Terpenoids from Soft Coral Sinularia nanolobata

Mar Drugs. 2018 Jan 24;16(2):40. doi: 10.3390/md16020040.

Abstract

A novel tetranorditerpenoid, sinubatin A (1) (having an unprecedented carbon skeleton), a new norditerpenoid, sinubatin B (2) (a 4,5-epoxycaryophyllene possessing an unusual methylfuran moiety side chain), and a known diterpenoid, gibberosin J (3) were isolated from soft coral Sinulariananolobata. The structures of the new compounds were elucidated by extensive analysis of spectroscopic data.

Keywords: Sinularia nanolobata; cytotoxicity; gibberosin J; norditerpenoid; tetranorditerpenoid.

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Models, Molecular
  • Molecular Structure
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Terpenes / chemistry*
  • Terpenes / isolation & purification
  • Terpenes / pharmacology

Substances

  • Antineoplastic Agents
  • Terpenes